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Tissue-bioelectronics interfaces.

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Title: Tissue-bioelectronics interfaces.
Authors: Li, Jiahong1 (AUTHOR), Qu, Jin1 (AUTHOR), Gao, Wei1 (AUTHOR) weigao@caltech.edu
Source: Chemical Society Reviews. 6/8/2026, Vol. 55 Issue 11, p6307-6343. 37p.
Subjects: Biocompatibility, Medical electronics, Flexibility (Mechanics), Therapeutics, Wearable technology, Patient monitoring
Abstract: Wearable and implantable bioelectronics enable continuous physiological monitoring and therapeutic modulation, yet their performance critically depends on the stability and conformality of the interfaces with soft and dynamic biological tissues. Mechanical and biochemical mismatches between conventional electronic materials and living tissues often lead to interfacial stress, unstable contact, and inflammatory responses that compromise the long-term function of bioelectronics. This review presents a mechanism-driven framework for understanding tissue–bioelectronics interfaces by systematically examining the physical, chemical, and biological interactions that govern device–tissue coupling across temporal and length scales. We show how these interfacial mechanisms inform key design principles in structural engineering and materials development, enabling improved mechanical compliance, adhesion, and long-term interfacial stability. We further highlight recent advances in fabrication strategies that support soft, conformal, and multifunctional bioelectronic systems, together with representative applications spanning physiological sensing and therapeutic modulation. Finally, we discuss emerging strategies for mitigating foreign-body responses and outline remaining challenges and opportunities for achieving durable, adaptive, and clinically translatable tissue–bioelectronics interfaces. [ABSTRACT FROM AUTHOR]
Copyright of Chemical Society Reviews is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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  Data: Tissue-bioelectronics interfaces.
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  Data: <searchLink fieldCode="AR" term="%22Li%2C+Jiahong%22">Li, Jiahong</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Qu%2C+Jin%22">Qu, Jin</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Gao%2C+Wei%22">Gao, Wei</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> weigao@caltech.edu</i>
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  Data: <searchLink fieldCode="JN" term="%22Chemical+Society+Reviews%22">Chemical Society Reviews</searchLink>. 6/8/2026, Vol. 55 Issue 11, p6307-6343. 37p.
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  Data: <searchLink fieldCode="DE" term="%22Biocompatibility%22">Biocompatibility</searchLink><br /><searchLink fieldCode="DE" term="%22Medical+electronics%22">Medical electronics</searchLink><br /><searchLink fieldCode="DE" term="%22Flexibility+%28Mechanics%29%22">Flexibility (Mechanics)</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink><br /><searchLink fieldCode="DE" term="%22Wearable+technology%22">Wearable technology</searchLink><br /><searchLink fieldCode="DE" term="%22Patient+monitoring%22">Patient monitoring</searchLink>
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  Data: Wearable and implantable bioelectronics enable continuous physiological monitoring and therapeutic modulation, yet their performance critically depends on the stability and conformality of the interfaces with soft and dynamic biological tissues. Mechanical and biochemical mismatches between conventional electronic materials and living tissues often lead to interfacial stress, unstable contact, and inflammatory responses that compromise the long-term function of bioelectronics. This review presents a mechanism-driven framework for understanding tissue–bioelectronics interfaces by systematically examining the physical, chemical, and biological interactions that govern device–tissue coupling across temporal and length scales. We show how these interfacial mechanisms inform key design principles in structural engineering and materials development, enabling improved mechanical compliance, adhesion, and long-term interfacial stability. We further highlight recent advances in fabrication strategies that support soft, conformal, and multifunctional bioelectronic systems, together with representative applications spanning physiological sensing and therapeutic modulation. Finally, we discuss emerging strategies for mitigating foreign-body responses and outline remaining challenges and opportunities for achieving durable, adaptive, and clinically translatable tissue–bioelectronics interfaces. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Chemical Society Reviews is the property of Royal Society of Chemistry and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1039/d5cs01422k
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      – Code: eng
        Text: English
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      – SubjectFull: Biocompatibility
        Type: general
      – SubjectFull: Medical electronics
        Type: general
      – SubjectFull: Flexibility (Mechanics)
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      – SubjectFull: Therapeutics
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      – SubjectFull: Wearable technology
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      – SubjectFull: Patient monitoring
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      – TitleFull: Tissue-bioelectronics interfaces.
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              M: 06
              Text: 6/8/2026
              Type: published
              Y: 2026
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