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Montmorillonite in next-generation drug delivery: patent trends, safety insights, and industrial advancements.

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Title: Montmorillonite in next-generation drug delivery: patent trends, safety insights, and industrial advancements.
Authors: Asif, Afzal Haq1 (AUTHOR), Asha, B. R.2 (AUTHOR), Prasanthi, Samathoti3 (AUTHOR), Goudanavar, Prakash2 (AUTHOR), Prashantha, Kalappa4 (AUTHOR), Srikruthi, K. S.2 (AUTHOR), Naveen, N. Raghavendra2 (AUTHOR) raghavendra.naveen@gmail.com, Meravanige, Girish5 (AUTHOR), Shiroorka, Predeepkumar Narayanappa5 (AUTHOR), Swaroop, Krishna5 (AUTHOR), Sreenivasalu, Pavan Kumar Pavagada6 (AUTHOR), Sreeharsha, Nagaraja7 (AUTHOR) sharsha@kfu.edu.sa
Source: Journal of Materials Science: Materials in Medicine. 4/24/2026, Vol. 37 Issue 1, p1-17. 17p.
Subjects: Montmorillonite, Drug delivery systems, Technological innovations, Polymeric drug delivery systems, Intellectual property, Drug additives, Nanocomposite materials, Biocompatibility
Abstract: Montmorillonite (MMT) is a natural clay mineral and the major component of bentonite, and it possesses an exceptional swelling capacity, a high potential for adsorption, and excellent biocompatibility. Therefore, MMT has been identified as an attractive candidate for pharmaceutical applications in drug nano delivery systems. In recent years, research on MMT has also gained momentum because of its ability to improve the solubility, rate of dissolution, and bioavailability of poor-water-soluble drugs in polymeric nanocomposites. Although much research has been done on the formulation advantages of MMT, critical analysis of their translational progress and industrial uptake remains inadequate. This reviews an in-depth study of the role of MMT as a pharmaceutical excipient in nano drug delivery through a synergy of published work and patent landscape analysis. Patents on MMT-based formulations are sequenced and scrutinized to identify significant players in the industry, therapeutic applications, and emerging patterns of technology. In the comparative assessment of research publications vis-a-vis patents in the decade under review, evolving innovation patterns have of late drawn attention to scalable, multifunctional, clinically relevant MMT nanocomposites. Overall, the review indicates how MMT is gaining importance in pharmaceutical development and what it will provide for the future concerning rational design, regulatory convergence, and commercialization of MMT-embedded polymeric nano drug delivery systems. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Materials Science: Materials in Medicine is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Montmorillonite in next-generation drug delivery: patent trends, safety insights, and industrial advancements.
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  Data: <searchLink fieldCode="AR" term="%22Asif%2C+Afzal+Haq%22">Asif, Afzal Haq</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Asha%2C+B%2E+R%2E%22">Asha, B. R.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Prasanthi%2C+Samathoti%22">Prasanthi, Samathoti</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Goudanavar%2C+Prakash%22">Goudanavar, Prakash</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Prashantha%2C+Kalappa%22">Prashantha, Kalappa</searchLink><relatesTo>4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Srikruthi%2C+K%2E+S%2E%22">Srikruthi, K. S.</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Naveen%2C+N%2E+Raghavendra%22">Naveen, N. Raghavendra</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> raghavendra.naveen@gmail.com</i><br /><searchLink fieldCode="AR" term="%22Meravanige%2C+Girish%22">Meravanige, Girish</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Shiroorka%2C+Predeepkumar+Narayanappa%22">Shiroorka, Predeepkumar Narayanappa</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Swaroop%2C+Krishna%22">Swaroop, Krishna</searchLink><relatesTo>5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sreenivasalu%2C+Pavan+Kumar+Pavagada%22">Sreenivasalu, Pavan Kumar Pavagada</searchLink><relatesTo>6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Sreeharsha%2C+Nagaraja%22">Sreeharsha, Nagaraja</searchLink><relatesTo>7</relatesTo> (AUTHOR)<i> sharsha@kfu.edu.sa</i>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Materials+Science%3A+Materials+in+Medicine%22">Journal of Materials Science: Materials in Medicine</searchLink>. 4/24/2026, Vol. 37 Issue 1, p1-17. 17p.
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  Data: <searchLink fieldCode="DE" term="%22Montmorillonite%22">Montmorillonite</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+delivery+systems%22">Drug delivery systems</searchLink><br /><searchLink fieldCode="DE" term="%22Technological+innovations%22">Technological innovations</searchLink><br /><searchLink fieldCode="DE" term="%22Polymeric+drug+delivery+systems%22">Polymeric drug delivery systems</searchLink><br /><searchLink fieldCode="DE" term="%22Intellectual+property%22">Intellectual property</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+additives%22">Drug additives</searchLink><br /><searchLink fieldCode="DE" term="%22Nanocomposite+materials%22">Nanocomposite materials</searchLink><br /><searchLink fieldCode="DE" term="%22Biocompatibility%22">Biocompatibility</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Montmorillonite (MMT) is a natural clay mineral and the major component of bentonite, and it possesses an exceptional swelling capacity, a high potential for adsorption, and excellent biocompatibility. Therefore, MMT has been identified as an attractive candidate for pharmaceutical applications in drug nano delivery systems. In recent years, research on MMT has also gained momentum because of its ability to improve the solubility, rate of dissolution, and bioavailability of poor-water-soluble drugs in polymeric nanocomposites. Although much research has been done on the formulation advantages of MMT, critical analysis of their translational progress and industrial uptake remains inadequate. This reviews an in-depth study of the role of MMT as a pharmaceutical excipient in nano drug delivery through a synergy of published work and patent landscape analysis. Patents on MMT-based formulations are sequenced and scrutinized to identify significant players in the industry, therapeutic applications, and emerging patterns of technology. In the comparative assessment of research publications vis-a-vis patents in the decade under review, evolving innovation patterns have of late drawn attention to scalable, multifunctional, clinically relevant MMT nanocomposites. Overall, the review indicates how MMT is gaining importance in pharmaceutical development and what it will provide for the future concerning rational design, regulatory convergence, and commercialization of MMT-embedded polymeric nano drug delivery systems. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Journal of Materials Science: Materials in Medicine is the property of Springer Nature and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1007/s10856-026-07031-4
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        Text: English
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      – SubjectFull: Drug delivery systems
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