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Crystal structures of (S)-3-{1-[(4-chlorophenyl)-sulfonyl]piperidin-2-yl}pyridine, (S)-3-[1-(4-methylphenyl)piperidin-2-yl]pyridine, (S)-3-{1-[(4-methoxyphenyl)sulfonyl]piperidin-2-yl}pyridine and (S)-3-{1-[(3,4-dimethylphenyl)sulfonyl]piperidin-2-yl}pyridine

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Title: Crystal structures of (S)-3-{1-[(4-chlorophenyl)-sulfonyl]piperidin-2-yl}pyridine, (S)-3-[1-(4-methylphenyl)piperidin-2-yl]pyridine, (S)-3-{1-[(4-methoxyphenyl)sulfonyl]piperidin-2-yl}pyridine and (S)-3-{1-[(3,4-dimethylphenyl)sulfonyl]piperidin-2-yl}pyridine
Authors: Okmanov, R. Ya.1 raxul@mail.ru, Olimova, M. I.1, Yuldashova, I. E.1, Azimova, G. Z.2, Pulatova, F. A.3
Source: Acta Crystallographica Section E: Crystallographic Communications. Jun2026, Vol. 82 Issue 6, p557-561. 24p.
Subjects: Piperidine, Sulfonyl compounds, Chemical reactions, Crystal structure, Molecular conformation, Chirality, Pyridine derivatives, Heterocyclic chemistry
Abstract: In the presence of trimethylamine, new compounds were obtained by arylsulfonylation of 3-(piperidin-2-yl)pyridine (the alkaloid anabasine), namely: (S)-3-{1-[(4-chlorophenyl)sulfonyl]piperidin-2-yl}pyridine, C16H17ClN2O2S (1); (S)- 3-[1-(4-methylphenyl)piperidin-2-yl]pyridine, C17H20N2O2S (2); (S)-3-{1-[(4- methoxyphenyl)sulfonyl]piperidin-2-yl}pyridine, C17H20N2O3S (3); and (S)-3- {1-[(3,4-dimethylphenyl)sulfonyl]piperidin-2-yl}pyridine, C18H22N2O2S (4). In the crystal structures, the spatial arrangement of the pyridine and piperidine rings around the Csp2--C* bond, as well as the orientation of the benzene ring of the arylsulfonyl group relative to the anabasine moiety, are analyzed. [ABSTRACT FROM AUTHOR]
Copyright of Acta Crystallographica Section E: Crystallographic Communications is the property of International Union of Crystallography - IUCr and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: Crystal structures of (S)-3-{1-[(4-chlorophenyl)-sulfonyl]piperidin-2-yl}pyridine, (S)-3-[1-(4-methylphenyl)piperidin-2-yl]pyridine, (S)-3-{1-[(4-methoxyphenyl)sulfonyl]piperidin-2-yl}pyridine and (S)-3-{1-[(3,4-dimethylphenyl)sulfonyl]piperidin-2-yl}pyridine
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  Data: <searchLink fieldCode="JN" term="%22Acta+Crystallographica+Section+E%3A+Crystallographic+Communications%22">Acta Crystallographica Section E: Crystallographic Communications</searchLink>. Jun2026, Vol. 82 Issue 6, p557-561. 24p.
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  Data: <searchLink fieldCode="DE" term="%22Piperidine%22">Piperidine</searchLink><br /><searchLink fieldCode="DE" term="%22Sulfonyl+compounds%22">Sulfonyl compounds</searchLink><br /><searchLink fieldCode="DE" term="%22Chemical+reactions%22">Chemical reactions</searchLink><br /><searchLink fieldCode="DE" term="%22Crystal+structure%22">Crystal structure</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+conformation%22">Molecular conformation</searchLink><br /><searchLink fieldCode="DE" term="%22Chirality%22">Chirality</searchLink><br /><searchLink fieldCode="DE" term="%22Pyridine+derivatives%22">Pyridine derivatives</searchLink><br /><searchLink fieldCode="DE" term="%22Heterocyclic+chemistry%22">Heterocyclic chemistry</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: In the presence of trimethylamine, new compounds were obtained by arylsulfonylation of 3-(piperidin-2-yl)pyridine (the alkaloid anabasine), namely: (S)-3-{1-[(4-chlorophenyl)sulfonyl]piperidin-2-yl}pyridine, C16H17ClN2O2S (1); (S)- 3-[1-(4-methylphenyl)piperidin-2-yl]pyridine, C17H20N2O2S (2); (S)-3-{1-[(4- methoxyphenyl)sulfonyl]piperidin-2-yl}pyridine, C17H20N2O3S (3); and (S)-3- {1-[(3,4-dimethylphenyl)sulfonyl]piperidin-2-yl}pyridine, C18H22N2O2S (4). In the crystal structures, the spatial arrangement of the pyridine and piperidine rings around the Csp2--C* bond, as well as the orientation of the benzene ring of the arylsulfonyl group relative to the anabasine moiety, are analyzed. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Acta Crystallographica Section E: Crystallographic Communications is the property of International Union of Crystallography - IUCr and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1107/S2056989026004524
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        Text: English
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        PageCount: 24
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      – SubjectFull: Piperidine
        Type: general
      – SubjectFull: Sulfonyl compounds
        Type: general
      – SubjectFull: Chemical reactions
        Type: general
      – SubjectFull: Crystal structure
        Type: general
      – SubjectFull: Molecular conformation
        Type: general
      – SubjectFull: Chirality
        Type: general
      – SubjectFull: Pyridine derivatives
        Type: general
      – SubjectFull: Heterocyclic chemistry
        Type: general
    Titles:
      – TitleFull: Crystal structures of (S)-3-{1-[(4-chlorophenyl)-sulfonyl]piperidin-2-yl}pyridine, (S)-3-[1-(4-methylphenyl)piperidin-2-yl]pyridine, (S)-3-{1-[(4-methoxyphenyl)sulfonyl]piperidin-2-yl}pyridine and (S)-3-{1-[(3,4-dimethylphenyl)sulfonyl]piperidin-2-yl}pyridine
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            NameFull: Okmanov, R. Ya.
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            NameFull: Olimova, M. I.
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            – D: 01
              M: 06
              Text: Jun2026
              Type: published
              Y: 2026
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