Novel Enzymatic Reagentless Glucose Biosensors Based on Noble Metal Nanostructures.
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| Title: | Novel Enzymatic Reagentless Glucose Biosensors Based on Noble Metal Nanostructures. |
|---|---|
| Authors: | German, Natalija1 (AUTHOR) anton.popov@chgf.vu.lt, Popov, Anton1,2 (AUTHOR), Ramanaviciene, Almira1,2 (AUTHOR) almira.ramanaviciene@chf.vu.lt |
| Source: | Polymers (20734360). Jun2026, Vol. 18 Issue 11, p1273. 17p. |
| Subjects: | Gold nanoparticles, Glucose oxidase, Metal nanoparticles, Electrochemical sensors, Routine diagnostic tests, Biosensors, Blood sugar monitors |
| Abstract: | Reagentless glucose biosensors with redox mediator—polymerized 1,10-phenanthroline-5,6-dione (pPD)—were developed and electrochemically investigated. Three types of biosensors based on graphite rod (GR) electrodes modified by (i) 13 nm of gold nanoparticles (AuNPs), (ii) electrochemically synthesized dendritic gold nanostructures (DAuNSs), and (iii) platinum nanostructures (PtNSs) were prepared. All electrodes were modified by glucose oxidase (GOx), and the pPD was polymerized for 2 h. Thus, GR/AuNPs/GOx/pPD, GR/DAuNSs/GOx/pPD, and GR/PtNSs/GOx/pPD electrodes were developed and electrochemically characterized. The electrode without noble metal nanostructures (GR/GOx/pPD) was used as the control. The biosensor based on the GR/DAuNSs/GOx/pPD electrode exhibited the best performance, with the sensitivity of 2.58 μA/(mM cm2), the linear range up to 93.7 mM, the limit of detection 0.182 mM, the reproducibility and repeatability of 4.99 and 4.80%, and the storage stability (50% of initial current responses (t1/2)) for up to 19 days. The achieved high resistance to interfering materials enabled precise glucose detection in real samples, including human serum and beverages. The technological solutions presented in this paper are anticipated to provide opportunities and benefits of developing novel enzymatic reagentless glucose biosensors based on noble metal nanostructures for use in clinical assays and general diagnostics, including blood glucose monitoring in people with diabetes. [ABSTRACT FROM AUTHOR] |
| Copyright of Polymers (20734360) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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| Header | DbId: egs DbLabel: Engineering Source An: 194587537 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Novel Enzymatic Reagentless Glucose Biosensors Based on Noble Metal Nanostructures. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22German%2C+Natalija%22">German, Natalija</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> anton.popov@chgf.vu.lt</i><br /><searchLink fieldCode="AR" term="%22Popov%2C+Anton%22">Popov, Anton</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Ramanaviciene%2C+Almira%22">Ramanaviciene, Almira</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<i> almira.ramanaviciene@chf.vu.lt</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Polymers+%2820734360%29%22">Polymers (20734360)</searchLink>. Jun2026, Vol. 18 Issue 11, p1273. 17p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Gold+nanoparticles%22">Gold nanoparticles</searchLink><br /><searchLink fieldCode="DE" term="%22Glucose+oxidase%22">Glucose oxidase</searchLink><br /><searchLink fieldCode="DE" term="%22Metal+nanoparticles%22">Metal nanoparticles</searchLink><br /><searchLink fieldCode="DE" term="%22Electrochemical+sensors%22">Electrochemical sensors</searchLink><br /><searchLink fieldCode="DE" term="%22Routine+diagnostic+tests%22">Routine diagnostic tests</searchLink><br /><searchLink fieldCode="DE" term="%22Biosensors%22">Biosensors</searchLink><br /><searchLink fieldCode="DE" term="%22Blood+sugar+monitors%22">Blood sugar monitors</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Reagentless glucose biosensors with redox mediator—polymerized 1,10-phenanthroline-5,6-dione (pPD)—were developed and electrochemically investigated. Three types of biosensors based on graphite rod (GR) electrodes modified by (i) 13 nm of gold nanoparticles (AuNPs), (ii) electrochemically synthesized dendritic gold nanostructures (DAuNSs), and (iii) platinum nanostructures (PtNSs) were prepared. All electrodes were modified by glucose oxidase (GOx), and the pPD was polymerized for 2 h. Thus, GR/AuNPs/GOx/pPD, GR/DAuNSs/GOx/pPD, and GR/PtNSs/GOx/pPD electrodes were developed and electrochemically characterized. The electrode without noble metal nanostructures (GR/GOx/pPD) was used as the control. The biosensor based on the GR/DAuNSs/GOx/pPD electrode exhibited the best performance, with the sensitivity of 2.58 μA/(mM cm2), the linear range up to 93.7 mM, the limit of detection 0.182 mM, the reproducibility and repeatability of 4.99 and 4.80%, and the storage stability (50% of initial current responses (t1/2)) for up to 19 days. The achieved high resistance to interfering materials enabled precise glucose detection in real samples, including human serum and beverages. The technological solutions presented in this paper are anticipated to provide opportunities and benefits of developing novel enzymatic reagentless glucose biosensors based on noble metal nanostructures for use in clinical assays and general diagnostics, including blood glucose monitoring in people with diabetes. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Polymers (20734360) is the property of MDPI and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.3390/polym18111273 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 17 StartPage: 1273 Subjects: – SubjectFull: Gold nanoparticles Type: general – SubjectFull: Glucose oxidase Type: general – SubjectFull: Metal nanoparticles Type: general – SubjectFull: Electrochemical sensors Type: general – SubjectFull: Routine diagnostic tests Type: general – SubjectFull: Biosensors Type: general – SubjectFull: Blood sugar monitors Type: general Titles: – TitleFull: Novel Enzymatic Reagentless Glucose Biosensors Based on Noble Metal Nanostructures. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: German, Natalija – PersonEntity: Name: NameFull: Popov, Anton – PersonEntity: Name: NameFull: Ramanaviciene, Almira IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 20734360 Numbering: – Type: volume Value: 18 – Type: issue Value: 11 Titles: – TitleFull: Polymers (20734360) Type: main |
| ResultId | 1 |
