HIV-1 STRATEGIES OF IMMUNE EVASION.
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| Title: | HIV-1 STRATEGIES OF IMMUNE EVASION. |
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| Authors: | Castiglione, F.1 f.castiglione@iac.cnr.it, Bernaschi, M.1 m.bernaschi@iac.cnr.it |
| Source: | International Journal of Modern Physics C: Computational Physics & Physical Computation. Dec2005, Vol. 16 Issue 12, p1869-1878. 10p. 5 Graphs. |
| Subjects: | HIV infections, HIV, Phenotypes, Infectious disease transmission, Epidemiology, Immune response, Computer simulation |
| Abstract: | We simulate the progression of the HIV-1 infection in untreated host organisms. The phenotype features of the virus are represented by the replication rate, the probability of activating the transcription, the mutation rate and the capacity to stimulate an immune response (the so-called immunogenicity). It is very difficult to study in-vivo or in-vitro how these characteristics of the virus influence the evolution of the disease. Therefore we resorted to simulations based on a computer model validated in previous studies. We observe, by means of computer experiments, that the virus continuously evolves under the selective pressure of an immune response whose effectiveness downgrades along with the disease progression. The results of the simulations show that immunogenicity is the most important factor in determining the rate of disease progression but, by itself, it is not sufficient to drive the disease to a conclusion in all cases. [ABSTRACT FROM AUTHOR] |
| Copyright of International Journal of Modern Physics C: Computational Physics & Physical Computation is the property of World Scientific Publishing Company and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
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