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No Association between CART (Cocaine- and Amphetamine-Regulated Transcript) Gene and Methamphetamine Dependence.

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Title: No Association between CART (Cocaine- and Amphetamine-Regulated Transcript) Gene and Methamphetamine Dependence.
Authors: MORIO, A.1 (AUTHOR), UJIKE, H.1,2 (AUTHOR), NOMURA, A.3 (AUTHOR), TANAKA, Y.1 (AUTHOR), MORITA, Y.1 (AUTHOR), OTANI, K.1 (AUTHOR), KISHIMOTO, M.1 (AUTHOR), HARANO, M.2,4 (AUTHOR), INADA, T.2,5 (AUTHOR), KOMIYAMA, T.2,6 (AUTHOR), YAMADA, M.2,7 (AUTHOR), SEKINE, Y.2,8 (AUTHOR), IWATA, N.2,9 (AUTHOR), IYO, M.2,10 (AUTHOR), SORA, I.2,11 (AUTHOR), OZAKI, N.2,12 (AUTHOR), KURODA, S.1 (AUTHOR)
Source: Annals of the New York Academy of Sciences. 2006, Vol. 1074 Issue 1, p411-417. 7p. 3 Charts.
Subjects: Cocaine, Amphetamines, Methamphetamine abuse, Drug abuse, Genetic research
Abstract: Cocaine- and amphetamine-regulated transcript (CART) was originally discovered as a peptide that increased in the rat striatum after injection of a psychostimulant drug, such as cocaine or amphetamine, and is suggested to play potential roles in drug dependence. We tested the genetic association between the CART gene and methamphetamine (METH) dependence and/or psychosis. The subjects were 203 patients with METH dependence and 239 age- and gender-matched healthy controls. Two single nucleotide polymorphisms (SNPs) of the CART gene, −156A>G and IVS1 + 224G>A, were examined . There were no significant differences in genotype and allele distributions of the polymorphisms between patients with METH dependence and/or psychosis and controls. Neither were significant differences in subgroups of clinical phenotypes, for example, age at first consumption of METH, latency to onset of psychotic symptoms after the first consumption of METH, prognosis of psychosis after therapy, complication of spontaneous relapse to a psychotic state, or multisubstance abuse status, observed. The present findings suggest that the CART gene may not play a pivotal role in the development of METH dependence and psychosis, at least in a Japanese population. [ABSTRACT FROM AUTHOR]
Copyright of Annals of the New York Academy of Sciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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DbLabel: Engineering Source
An: 22419640
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  Data: No Association between CART (Cocaine- and Amphetamine-Regulated Transcript) Gene and Methamphetamine Dependence.
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  Data: <searchLink fieldCode="AR" term="%22MORIO%2C+A%2E%22">MORIO, A.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22UJIKE%2C+H%2E%22">UJIKE, H.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22NOMURA%2C+A%2E%22">NOMURA, A.</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22TANAKA%2C+Y%2E%22">TANAKA, Y.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22MORITA%2C+Y%2E%22">MORITA, Y.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22OTANI%2C+K%2E%22">OTANI, K.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22KISHIMOTO%2C+M%2E%22">KISHIMOTO, M.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22HARANO%2C+M%2E%22">HARANO, M.</searchLink><relatesTo>2,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22INADA%2C+T%2E%22">INADA, T.</searchLink><relatesTo>2,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22KOMIYAMA%2C+T%2E%22">KOMIYAMA, T.</searchLink><relatesTo>2,6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22YAMADA%2C+M%2E%22">YAMADA, M.</searchLink><relatesTo>2,7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22SEKINE%2C+Y%2E%22">SEKINE, Y.</searchLink><relatesTo>2,8</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22IWATA%2C+N%2E%22">IWATA, N.</searchLink><relatesTo>2,9</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22IYO%2C+M%2E%22">IYO, M.</searchLink><relatesTo>2,10</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22SORA%2C+I%2E%22">SORA, I.</searchLink><relatesTo>2,11</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22OZAKI%2C+N%2E%22">OZAKI, N.</searchLink><relatesTo>2,12</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22KURODA%2C+S%2E%22">KURODA, S.</searchLink><relatesTo>1</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Annals+of+the+New+York+Academy+of+Sciences%22">Annals of the New York Academy of Sciences</searchLink>. 2006, Vol. 1074 Issue 1, p411-417. 7p. 3 Charts.
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  Label: Subjects
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  Data: <searchLink fieldCode="DE" term="%22Cocaine%22">Cocaine</searchLink><br /><searchLink fieldCode="DE" term="%22Amphetamines%22">Amphetamines</searchLink><br /><searchLink fieldCode="DE" term="%22Methamphetamine+abuse%22">Methamphetamine abuse</searchLink><br /><searchLink fieldCode="DE" term="%22Drug+abuse%22">Drug abuse</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+research%22">Genetic research</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Cocaine- and amphetamine-regulated transcript (CART) was originally discovered as a peptide that increased in the rat striatum after injection of a psychostimulant drug, such as cocaine or amphetamine, and is suggested to play potential roles in drug dependence. We tested the genetic association between the CART gene and methamphetamine (METH) dependence and/or psychosis. The subjects were 203 patients with METH dependence and 239 age- and gender-matched healthy controls. Two single nucleotide polymorphisms (SNPs) of the CART gene, −156A>G and IVS1 + 224G>A, were examined . There were no significant differences in genotype and allele distributions of the polymorphisms between patients with METH dependence and/or psychosis and controls. Neither were significant differences in subgroups of clinical phenotypes, for example, age at first consumption of METH, latency to onset of psychotic symptoms after the first consumption of METH, prognosis of psychosis after therapy, complication of spontaneous relapse to a psychotic state, or multisubstance abuse status, observed. The present findings suggest that the CART gene may not play a pivotal role in the development of METH dependence and psychosis, at least in a Japanese population. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Annals of the New York Academy of Sciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1196/annals.1369.041
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        Text: English
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      – SubjectFull: Cocaine
        Type: general
      – SubjectFull: Amphetamines
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      – SubjectFull: Methamphetamine abuse
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      – SubjectFull: Genetic research
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