Association Study of the Tumor Necrosis Factor-α Gene and Its 1A Receptor Gene with Methamphetamine Dependence.
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| Title: | Association Study of the Tumor Necrosis Factor-α Gene and Its 1A Receptor Gene with Methamphetamine Dependence. |
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| Authors: | NOMURA, A.1,2,3 (AUTHOR), UJIKE, H.1,2 (AUTHOR), TANAKA, Y.1 (AUTHOR), KISHIMOTO, M.1 (AUTHOR), OTANI, K.1 (AUTHOR), MORITA, Y.1 (AUTHOR), MORIO, A.1 (AUTHOR), HARANO, M.2,4 (AUTHOR), INADA, T.2,5 (AUTHOR), YAMADA, M.2,6 (AUTHOR), KOMIYAMA, T.2,7 (AUTHOR), HORI, T.2,7 (AUTHOR), SEKINE, Y.2,8 (AUTHOR), IWATA, N.2,9 (AUTHOR), SORA, I.2,10 (AUTHOR), IYO, M.2,11 (AUTHOR), OZAKI, N.2,12 (AUTHOR), KURODA, S.1 (AUTHOR) |
| Source: | Annals of the New York Academy of Sciences. 2006, Vol. 1074 Issue 1, p116-124. 9p. 1 Diagram, 3 Charts. |
| Subjects: | Tumor necrosis factors, Methamphetamine, Substance abuse, Brain, Genetic polymorphisms, Genes |
| Abstract: | Recent preclinical findings that repeated treatment with methamphetamine (METH) induced an increase in tumor necrosis factor-α (TNF-α) mRNA in some brain regions and that TNF-α blocked METH neurotoxicity and rewarding effects suggest TNF-α, a multifunctional pro-inflammatory cytokine, may be involved in METH dependence. We hypothesized that genetic polymorphisms of the TNF-α gene and its receptor genes may be associated with vulnerability to METH dependence. Genetic association of -308G>A and -857C>T in the promotor region of the TNF-α gene, and 36A>G in exon 1 of the TNF receptor 1A gene (TNFR-SF1A), were analyzed in patients with METH dependence ( n= 185) and healthy controls ( n= 221) in a Japanese population. No significant association of alleles or haplotypes of the TNF-α or TNFR-SF1A genes with METH dependence was found. Neither was any significant association of clinical phenotype with METH dependence found. These results suggest that genetic variations in the TNF-α gene and its receptor genes may not be involved in individual vulnerability to METH dependence. [ABSTRACT FROM AUTHOR] |
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| Database: | Engineering Source |
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| Abstract: | Recent preclinical findings that repeated treatment with methamphetamine (METH) induced an increase in tumor necrosis factor-α (TNF-α) mRNA in some brain regions and that TNF-α blocked METH neurotoxicity and rewarding effects suggest TNF-α, a multifunctional pro-inflammatory cytokine, may be involved in METH dependence. We hypothesized that genetic polymorphisms of the TNF-α gene and its receptor genes may be associated with vulnerability to METH dependence. Genetic association of -308G>A and -857C>T in the promotor region of the TNF-α gene, and 36A>G in exon 1 of the TNF receptor 1A gene (TNFR-SF1A), were analyzed in patients with METH dependence ( n= 185) and healthy controls ( n= 221) in a Japanese population. No significant association of alleles or haplotypes of the TNF-α or TNFR-SF1A genes with METH dependence was found. Neither was any significant association of clinical phenotype with METH dependence found. These results suggest that genetic variations in the TNF-α gene and its receptor genes may not be involved in individual vulnerability to METH dependence. [ABSTRACT FROM AUTHOR] |
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| ISSN: | 00778923 |
| DOI: | 10.1196/annals.1369.011 |
