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Association Study of the Tumor Necrosis Factor-α Gene and Its 1A Receptor Gene with Methamphetamine Dependence.

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Title: Association Study of the Tumor Necrosis Factor-α Gene and Its 1A Receptor Gene with Methamphetamine Dependence.
Authors: NOMURA, A.1,2,3 (AUTHOR), UJIKE, H.1,2 (AUTHOR), TANAKA, Y.1 (AUTHOR), KISHIMOTO, M.1 (AUTHOR), OTANI, K.1 (AUTHOR), MORITA, Y.1 (AUTHOR), MORIO, A.1 (AUTHOR), HARANO, M.2,4 (AUTHOR), INADA, T.2,5 (AUTHOR), YAMADA, M.2,6 (AUTHOR), KOMIYAMA, T.2,7 (AUTHOR), HORI, T.2,7 (AUTHOR), SEKINE, Y.2,8 (AUTHOR), IWATA, N.2,9 (AUTHOR), SORA, I.2,10 (AUTHOR), IYO, M.2,11 (AUTHOR), OZAKI, N.2,12 (AUTHOR), KURODA, S.1 (AUTHOR)
Source: Annals of the New York Academy of Sciences. 2006, Vol. 1074 Issue 1, p116-124. 9p. 1 Diagram, 3 Charts.
Subjects: Tumor necrosis factors, Methamphetamine, Substance abuse, Brain, Genetic polymorphisms, Genes
Abstract: Recent preclinical findings that repeated treatment with methamphetamine (METH) induced an increase in tumor necrosis factor-α (TNF-α) mRNA in some brain regions and that TNF-α blocked METH neurotoxicity and rewarding effects suggest TNF-α, a multifunctional pro-inflammatory cytokine, may be involved in METH dependence. We hypothesized that genetic polymorphisms of the TNF-α gene and its receptor genes may be associated with vulnerability to METH dependence. Genetic association of -308G>A and -857C>T in the promotor region of the TNF-α gene, and 36A>G in exon 1 of the TNF receptor 1A gene (TNFR-SF1A), were analyzed in patients with METH dependence ( n= 185) and healthy controls ( n= 221) in a Japanese population. No significant association of alleles or haplotypes of the TNF-α or TNFR-SF1A genes with METH dependence was found. Neither was any significant association of clinical phenotype with METH dependence found. These results suggest that genetic variations in the TNF-α gene and its receptor genes may not be involved in individual vulnerability to METH dependence. [ABSTRACT FROM AUTHOR]
Copyright of Annals of the New York Academy of Sciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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PubType: Academic Journal
PubTypeId: academicJournal
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  Data: Association Study of the Tumor Necrosis Factor-α Gene and Its 1A Receptor Gene with Methamphetamine Dependence.
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  Data: <searchLink fieldCode="AR" term="%22NOMURA%2C+A%2E%22">NOMURA, A.</searchLink><relatesTo>1,2,3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22UJIKE%2C+H%2E%22">UJIKE, H.</searchLink><relatesTo>1,2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22TANAKA%2C+Y%2E%22">TANAKA, Y.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22KISHIMOTO%2C+M%2E%22">KISHIMOTO, M.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22OTANI%2C+K%2E%22">OTANI, K.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22MORITA%2C+Y%2E%22">MORITA, Y.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22MORIO%2C+A%2E%22">MORIO, A.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22HARANO%2C+M%2E%22">HARANO, M.</searchLink><relatesTo>2,4</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22INADA%2C+T%2E%22">INADA, T.</searchLink><relatesTo>2,5</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22YAMADA%2C+M%2E%22">YAMADA, M.</searchLink><relatesTo>2,6</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22KOMIYAMA%2C+T%2E%22">KOMIYAMA, T.</searchLink><relatesTo>2,7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22HORI%2C+T%2E%22">HORI, T.</searchLink><relatesTo>2,7</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22SEKINE%2C+Y%2E%22">SEKINE, Y.</searchLink><relatesTo>2,8</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22IWATA%2C+N%2E%22">IWATA, N.</searchLink><relatesTo>2,9</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22SORA%2C+I%2E%22">SORA, I.</searchLink><relatesTo>2,10</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22IYO%2C+M%2E%22">IYO, M.</searchLink><relatesTo>2,11</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22OZAKI%2C+N%2E%22">OZAKI, N.</searchLink><relatesTo>2,12</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22KURODA%2C+S%2E%22">KURODA, S.</searchLink><relatesTo>1</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Annals+of+the+New+York+Academy+of+Sciences%22">Annals of the New York Academy of Sciences</searchLink>. 2006, Vol. 1074 Issue 1, p116-124. 9p. 1 Diagram, 3 Charts.
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  Data: <searchLink fieldCode="DE" term="%22Tumor+necrosis+factors%22">Tumor necrosis factors</searchLink><br /><searchLink fieldCode="DE" term="%22Methamphetamine%22">Methamphetamine</searchLink><br /><searchLink fieldCode="DE" term="%22Substance+abuse%22">Substance abuse</searchLink><br /><searchLink fieldCode="DE" term="%22Brain%22">Brain</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+polymorphisms%22">Genetic polymorphisms</searchLink><br /><searchLink fieldCode="DE" term="%22Genes%22">Genes</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Recent preclinical findings that repeated treatment with methamphetamine (METH) induced an increase in tumor necrosis factor-α (TNF-α) mRNA in some brain regions and that TNF-α blocked METH neurotoxicity and rewarding effects suggest TNF-α, a multifunctional pro-inflammatory cytokine, may be involved in METH dependence. We hypothesized that genetic polymorphisms of the TNF-α gene and its receptor genes may be associated with vulnerability to METH dependence. Genetic association of -308G>A and -857C>T in the promotor region of the TNF-α gene, and 36A>G in exon 1 of the TNF receptor 1A gene (TNFR-SF1A), were analyzed in patients with METH dependence ( n= 185) and healthy controls ( n= 221) in a Japanese population. No significant association of alleles or haplotypes of the TNF-α or TNFR-SF1A genes with METH dependence was found. Neither was any significant association of clinical phenotype with METH dependence found. These results suggest that genetic variations in the TNF-α gene and its receptor genes may not be involved in individual vulnerability to METH dependence. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Annals of the New York Academy of Sciences is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1196/annals.1369.011
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        Text: English
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        Type: general
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