Pre-treatment with mild whole-body heating prevents gastric ulcer induced by restraint and water-immersion stress in rats.

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Bibliographic Details
Title:	Pre-treatment with mild whole-body heating prevents gastric ulcer induced by restraint and water-immersion stress in rats.
Authors:	Itoh, Y. H., Noguchi, R.
Source:	International Journal of Hyperthermia. Mar/Apr2000, Vol. 16 Issue 2, p183-191. 9p.
Subjects:	Stomach ulcers, Heat shock proteins, Clinical medicine
Abstract:	The purpose of this study was to assess the preventive effect of pre-mild wholebody heating (WBH) on gastric ulcer induced by restraint and water-immersion stress. The ulcer index and ulcer area ratio in rats exposed to restraint and water-immersion stress were significantly decreased (p<0.05 for both) after pre-treatment with mild WBH, compared with non-pre-treated rats. Mortality of rats among the pre-treated with mild WBH (0%) was lower than in the control group (33%). The concentration of HSP 70f in the stomach (both fundic and pyloric mucosal areas) of rats pre-treated with mild WBH was significantly higher than in animals exposed to restraint and water-immersion stress alone (p<0.05) before exposed to stress, but was not significantly higher immediaely after stress or 1 or 3 days later. The HSP70f content of peripheral lymphocytes was increased by the pre-treatment with mild WBH. These results suggest that HSP 70f induced by pre-treatment with mild hyperthermia protects against more severe stress due to restraint and water-immersion, thereby preventing gastric ulcer formation. Pre-treatment with mild WBH is the safest cytoprotective method through the accumulation of HSP 70f. The concentration of HSP 70f in peripheral lymphocytes may be a useful clinical laboratory indicator for assessing the level of HSP 70f as having cytoprotective activity. [ABSTRACT FROM AUTHOR]
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Database:	Engineering Source

Description
Abstract:	The purpose of this study was to assess the preventive effect of pre-mild wholebody heating (WBH) on gastric ulcer induced by restraint and water-immersion stress. The ulcer index and ulcer area ratio in rats exposed to restraint and water-immersion stress were significantly decreased (p<0.05 for both) after pre-treatment with mild WBH, compared with non-pre-treated rats. Mortality of rats among the pre-treated with mild WBH (0%) was lower than in the control group (33%). The concentration of HSP 70f in the stomach (both fundic and pyloric mucosal areas) of rats pre-treated with mild WBH was significantly higher than in animals exposed to restraint and water-immersion stress alone (p<0.05) before exposed to stress, but was not significantly higher immediaely after stress or 1 or 3 days later. The HSP70f content of peripheral lymphocytes was increased by the pre-treatment with mild WBH. These results suggest that HSP 70f induced by pre-treatment with mild hyperthermia protects against more severe stress due to restraint and water-immersion, thereby preventing gastric ulcer formation. Pre-treatment with mild WBH is the safest cytoprotective method through the accumulation of HSP 70f. The concentration of HSP 70f in peripheral lymphocytes may be a useful clinical laboratory indicator for assessing the level of HSP 70f as having cytoprotective activity. [ABSTRACT FROM AUTHOR]
ISSN:	02656736
DOI:	10.1080/026567300285376