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Excitation functions for proton-induced reactions on natural hafnium: Production of 177Lu for medical use

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Title: Excitation functions for proton-induced reactions on natural hafnium: Production of 177Lu for medical use
Authors: Siiskonen, T.1 teemu.siiskonen@stuk.fi, Huikari, J.1, Haavisto, T.1,2, Bergman, J.3, Heselius, S.-J.3, Lill, J.-O.2,3, Lönnroth, T.2, Peräjärvi, K.1, Vartti, V.-P.1
Source: Nuclear Instruments & Methods in Physics Research Section B. Nov2009, Vol. 267 Issue 21/22, p3500-3504. 5p.
Subjects: Nuclear excitation, Nuclear medicine, Lutetium isotopes, Hafnium, Numerical calculations, Proton beams, Radioisotopes, Nuclear cross sections
Abstract: Abstract: There is an increasing interest in using radioisotopes of rare earth elements for internal radiotherapy and for imaging in nuclear medicine. 177Lu is one of the promising radionuclides. This article reports on the first measurements of the excitation function for the production of 177Lu with proton-beam energies up to 17MeV on natural hafnium targets. The experimental cross sections for the reaction natHf(p,x)177Lu were obtained by the activation of a stacked-foil target and subsequent gamma spectrometry. Theoretical cross sections were calculated up to 35MeV with the EMPIRE nuclear reaction model code. The measured and calculated cross sections were used for deriving the thick-target yields and for estimating the production of other nuclides than 177Lu. Measured production cross sections of 175,176,177,178Ta on the same target are also presented. [Copyright &y& Elsevier]
Copyright of Nuclear Instruments & Methods in Physics Research Section B is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 44938710
AccessLevel: 6
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PubTypeId: academicJournal
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  Label: Title
  Group: Ti
  Data: Excitation functions for proton-induced reactions on natural hafnium: Production of <superscript>177</superscript>Lu for medical use
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  Data: <searchLink fieldCode="AR" term="%22Siiskonen%2C+T%2E%22">Siiskonen, T.</searchLink><relatesTo>1</relatesTo><i> teemu.siiskonen@stuk.fi</i><br /><searchLink fieldCode="AR" term="%22Huikari%2C+J%2E%22">Huikari, J.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Haavisto%2C+T%2E%22">Haavisto, T.</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Bergman%2C+J%2E%22">Bergman, J.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Heselius%2C+S%2E-J%2E%22">Heselius, S.-J.</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Lill%2C+J%2E-O%2E%22">Lill, J.-O.</searchLink><relatesTo>2,3</relatesTo><br /><searchLink fieldCode="AR" term="%22Lönnroth%2C+T%2E%22">Lönnroth, T.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Peräjärvi%2C+K%2E%22">Peräjärvi, K.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Vartti%2C+V%2E-P%2E%22">Vartti, V.-P.</searchLink><relatesTo>1</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Nuclear+Instruments+%26+Methods+in+Physics+Research+Section+B%22">Nuclear Instruments & Methods in Physics Research Section B</searchLink>. Nov2009, Vol. 267 Issue 21/22, p3500-3504. 5p.
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  Data: <searchLink fieldCode="DE" term="%22Nuclear+excitation%22">Nuclear excitation</searchLink><br /><searchLink fieldCode="DE" term="%22Nuclear+medicine%22">Nuclear medicine</searchLink><br /><searchLink fieldCode="DE" term="%22Lutetium+isotopes%22">Lutetium isotopes</searchLink><br /><searchLink fieldCode="DE" term="%22Hafnium%22">Hafnium</searchLink><br /><searchLink fieldCode="DE" term="%22Numerical+calculations%22">Numerical calculations</searchLink><br /><searchLink fieldCode="DE" term="%22Proton+beams%22">Proton beams</searchLink><br /><searchLink fieldCode="DE" term="%22Radioisotopes%22">Radioisotopes</searchLink><br /><searchLink fieldCode="DE" term="%22Nuclear+cross+sections%22">Nuclear cross sections</searchLink>
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  Label: Abstract
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  Data: Abstract: There is an increasing interest in using radioisotopes of rare earth elements for internal radiotherapy and for imaging in nuclear medicine. 177Lu is one of the promising radionuclides. This article reports on the first measurements of the excitation function for the production of 177Lu with proton-beam energies up to 17MeV on natural hafnium targets. The experimental cross sections for the reaction natHf(p,x)177Lu were obtained by the activation of a stacked-foil target and subsequent gamma spectrometry. Theoretical cross sections were calculated up to 35MeV with the EMPIRE nuclear reaction model code. The measured and calculated cross sections were used for deriving the thick-target yields and for estimating the production of other nuclides than 177Lu. Measured production cross sections of 175,176,177,178Ta on the same target are also presented. [Copyright &y& Elsevier]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Nuclear Instruments & Methods in Physics Research Section B is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.nimb.2009.08.016
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      – Code: eng
        Text: English
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        PageCount: 5
        StartPage: 3500
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        Type: general
      – SubjectFull: Nuclear medicine
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      – SubjectFull: Lutetium isotopes
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      – SubjectFull: Hafnium
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      – SubjectFull: Proton beams
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      – SubjectFull: Radioisotopes
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      – SubjectFull: Nuclear cross sections
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      – TitleFull: Excitation functions for proton-induced reactions on natural hafnium: Production of 177Lu for medical use
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              M: 11
              Text: Nov2009
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