Experimental investigation and numerical simulation of 3He gas diffusion in simple geometries: Implications for analytical models of 3He MR lung morphometry
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| Title: | Experimental investigation and numerical simulation of 3He gas diffusion in simple geometries: Implications for analytical models of 3He MR lung morphometry |
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| Authors: | Parra-Robles, J. J.Parra-Robles@sheffield.ac.uk, Ajraoui, S.1, Deppe, M.H.1, Parnell, S.R.1, Wild, J.M. j.m.wild@sheffield.ac.uk |
| Source: | Journal of Magnetic Resonance. Jun2010, Vol. 204 Issue 2, p228-238. 11p. |
| Subjects: | Diffusion, Numerical analysis, Simulation methods & models, Magnetic resonance imaging, Lung radiography, Finite differences, Microstructure, Nuclear magnetic resonance, Gaussian processes |
| Abstract: | Abstract: Models of lung acinar geometry have been proposed to analytically describe the diffusion of 3He in the lung (as measured with pulsed gradient spin echo (PGSE) methods) as a possible means of characterizing lung microstructure from measurement of the 3He ADC. In this work, major limitations in these analytical models are highlighted in simple diffusion weighted experiments with 3He in cylindrical models of known geometry. The findings are substantiated with numerical simulations based on the same geometry using finite difference representation of the Bloch–Torrey equation. The validity of the existing “cylinder model” is discussed in terms of the physical diffusion regimes experienced and the basic reliance of the cylinder model and other ADC-based approaches on a Gaussian diffusion behaviour is highlighted. The results presented here demonstrate that physical assumptions of the cylinder model are not valid for large diffusion gradient strengths (above ∼15mT/m), which are commonly used for 3He ADC measurements in human lungs. [Copyright &y& Elsevier] |
| Copyright of Journal of Magnetic Resonance is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Engineering Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: egs DbLabel: Engineering Source An: 50982674 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Experimental investigation and numerical simulation of <superscript>3</superscript>He gas diffusion in simple geometries: Implications for analytical models of <superscript>3</superscript>He MR lung morphometry – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Parra-Robles%2C+J%2E%22">Parra-Robles, J.</searchLink><i> J.Parra-Robles@sheffield.ac.uk</i><br /><searchLink fieldCode="AR" term="%22Ajraoui%2C+S%2E%22">Ajraoui, S.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Deppe%2C+M%2EH%2E%22">Deppe, M.H.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Parnell%2C+S%2ER%2E%22">Parnell, S.R.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Wild%2C+J%2EM%2E%22">Wild, J.M.</searchLink><i> j.m.wild@sheffield.ac.uk</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Magnetic+Resonance%22">Journal of Magnetic Resonance</searchLink>. Jun2010, Vol. 204 Issue 2, p228-238. 11p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22Diffusion%22">Diffusion</searchLink><br /><searchLink fieldCode="DE" term="%22Numerical+analysis%22">Numerical analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Simulation+methods+%26+models%22">Simulation methods & models</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Lung+radiography%22">Lung radiography</searchLink><br /><searchLink fieldCode="DE" term="%22Finite+differences%22">Finite differences</searchLink><br /><searchLink fieldCode="DE" term="%22Microstructure%22">Microstructure</searchLink><br /><searchLink fieldCode="DE" term="%22Nuclear+magnetic+resonance%22">Nuclear magnetic resonance</searchLink><br /><searchLink fieldCode="DE" term="%22Gaussian+processes%22">Gaussian processes</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Abstract: Models of lung acinar geometry have been proposed to analytically describe the diffusion of 3He in the lung (as measured with pulsed gradient spin echo (PGSE) methods) as a possible means of characterizing lung microstructure from measurement of the 3He ADC. In this work, major limitations in these analytical models are highlighted in simple diffusion weighted experiments with 3He in cylindrical models of known geometry. The findings are substantiated with numerical simulations based on the same geometry using finite difference representation of the Bloch–Torrey equation. The validity of the existing “cylinder model” is discussed in terms of the physical diffusion regimes experienced and the basic reliance of the cylinder model and other ADC-based approaches on a Gaussian diffusion behaviour is highlighted. The results presented here demonstrate that physical assumptions of the cylinder model are not valid for large diffusion gradient strengths (above ∼15mT/m), which are commonly used for 3He ADC measurements in human lungs. [Copyright &y& Elsevier] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Magnetic Resonance is the property of Academic Press Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1016/j.jmr.2010.02.023 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 11 StartPage: 228 Subjects: – SubjectFull: Diffusion Type: general – SubjectFull: Numerical analysis Type: general – SubjectFull: Simulation methods & models Type: general – SubjectFull: Magnetic resonance imaging Type: general – SubjectFull: Lung radiography Type: general – SubjectFull: Finite differences Type: general – SubjectFull: Microstructure Type: general – SubjectFull: Nuclear magnetic resonance Type: general – SubjectFull: Gaussian processes Type: general Titles: – TitleFull: Experimental investigation and numerical simulation of 3He gas diffusion in simple geometries: Implications for analytical models of 3He MR lung morphometry Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Parra-Robles, J. – PersonEntity: Name: NameFull: Ajraoui, S. – PersonEntity: Name: NameFull: Deppe, M.H. – PersonEntity: Name: NameFull: Parnell, S.R. – PersonEntity: Name: NameFull: Wild, J.M. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 06 Text: Jun2010 Type: published Y: 2010 Identifiers: – Type: issn-print Value: 10907807 Numbering: – Type: volume Value: 204 – Type: issue Value: 2 Titles: – TitleFull: Journal of Magnetic Resonance Type: main |
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