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Superparamagnetic iron oxide nanoparticle targeting of MSCs in vascular injury

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Title: Superparamagnetic iron oxide nanoparticle targeting of MSCs in vascular injury
Authors: Riegler, Johannes1,2 j.riegler@stanford.edu, Liew, Aaron3, Hynes, Sean O.3, Ortega, Daniel4, O’Brien, Timothy3, Day, Richard M.5, Richards, Toby6, Sharif, Faisal3, Pankhurst, Quentin A.4,7, Lythgoe, Mark F.1
Source: Biomaterials. Mar2013, Vol. 34 Issue 8, p1987-1994. 8p.
Subjects: Myocardial infarction, Mesenchymal stem cells, Superparamagnetic materials, Iron oxide nanoparticles, Gene targeting, Arterial occlusions, Cellular therapy, Peripheral vascular disease treatment, Transluminal angioplasty
Abstract: Abstract: Vascular occlusion can result in fatal myocardial infarction, stroke or loss of limb in peripheral arterial disease. Interventional balloon angioplasty is a common first line procedure for vascular disease treatment, but long term success is limited by restenosis and neointimal hyperplasia. Cellular therapies have been proposed to mitigate these issues; however efficacy is low, in part due to poor cell retention. We show that magnetic targeting of mesenchymal stem cells gives rise to a 6-fold increase in cell retention following balloon angioplasty in a rabbit model using a clinically applicable permanent magnet. Cells labelled with superparamagnetic iron oxide nanoparticles exhibit no negative effects on cell viability, differentiation or secretion patterns. The increase in stem cell retention leads to a reduction in restenosis three weeks after cell delivery. [Copyright &y& Elsevier]
Copyright of Biomaterials is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Engineering Source
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DbLabel: Engineering Source
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PubType: Academic Journal
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  Data: Superparamagnetic iron oxide nanoparticle targeting of MSCs in vascular injury
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  Data: <searchLink fieldCode="JN" term="%22Biomaterials%22">Biomaterials</searchLink>. Mar2013, Vol. 34 Issue 8, p1987-1994. 8p.
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  Data: <searchLink fieldCode="DE" term="%22Myocardial+infarction%22">Myocardial infarction</searchLink><br /><searchLink fieldCode="DE" term="%22Mesenchymal+stem+cells%22">Mesenchymal stem cells</searchLink><br /><searchLink fieldCode="DE" term="%22Superparamagnetic+materials%22">Superparamagnetic materials</searchLink><br /><searchLink fieldCode="DE" term="%22Iron+oxide+nanoparticles%22">Iron oxide nanoparticles</searchLink><br /><searchLink fieldCode="DE" term="%22Gene+targeting%22">Gene targeting</searchLink><br /><searchLink fieldCode="DE" term="%22Arterial+occlusions%22">Arterial occlusions</searchLink><br /><searchLink fieldCode="DE" term="%22Cellular+therapy%22">Cellular therapy</searchLink><br /><searchLink fieldCode="DE" term="%22Peripheral+vascular+disease+treatment%22">Peripheral vascular disease treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Transluminal+angioplasty%22">Transluminal angioplasty</searchLink>
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  Data: Abstract: Vascular occlusion can result in fatal myocardial infarction, stroke or loss of limb in peripheral arterial disease. Interventional balloon angioplasty is a common first line procedure for vascular disease treatment, but long term success is limited by restenosis and neointimal hyperplasia. Cellular therapies have been proposed to mitigate these issues; however efficacy is low, in part due to poor cell retention. We show that magnetic targeting of mesenchymal stem cells gives rise to a 6-fold increase in cell retention following balloon angioplasty in a rabbit model using a clinically applicable permanent magnet. Cells labelled with superparamagnetic iron oxide nanoparticles exhibit no negative effects on cell viability, differentiation or secretion patterns. The increase in stem cell retention leads to a reduction in restenosis three weeks after cell delivery. [Copyright &y& Elsevier]
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  Data: <i>Copyright of Biomaterials is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1016/j.biomaterials.2012.11.040
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      – SubjectFull: Transluminal angioplasty
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              Text: Mar2013
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