Superparamagnetic iron oxide nanoparticle targeting of MSCs in vascular injury
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| Title: | Superparamagnetic iron oxide nanoparticle targeting of MSCs in vascular injury |
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| Authors: | Riegler, Johannes1,2 j.riegler@stanford.edu, Liew, Aaron3, Hynes, Sean O.3, Ortega, Daniel4, O’Brien, Timothy3, Day, Richard M.5, Richards, Toby6, Sharif, Faisal3, Pankhurst, Quentin A.4,7, Lythgoe, Mark F.1 |
| Source: | Biomaterials. Mar2013, Vol. 34 Issue 8, p1987-1994. 8p. |
| Subjects: | Myocardial infarction, Mesenchymal stem cells, Superparamagnetic materials, Iron oxide nanoparticles, Gene targeting, Arterial occlusions, Cellular therapy, Peripheral vascular disease treatment, Transluminal angioplasty |
| Abstract: | Abstract: Vascular occlusion can result in fatal myocardial infarction, stroke or loss of limb in peripheral arterial disease. Interventional balloon angioplasty is a common first line procedure for vascular disease treatment, but long term success is limited by restenosis and neointimal hyperplasia. Cellular therapies have been proposed to mitigate these issues; however efficacy is low, in part due to poor cell retention. We show that magnetic targeting of mesenchymal stem cells gives rise to a 6-fold increase in cell retention following balloon angioplasty in a rabbit model using a clinically applicable permanent magnet. Cells labelled with superparamagnetic iron oxide nanoparticles exhibit no negative effects on cell viability, differentiation or secretion patterns. The increase in stem cell retention leads to a reduction in restenosis three weeks after cell delivery. [Copyright &y& Elsevier] |
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| Database: | Engineering Source |
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