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Genomic assay reveals tolerance of DNA damage by both translesion DNA synthesis and homology-dependent repair in mammalian cells.

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Title: Genomic assay reveals tolerance of DNA damage by both translesion DNA synthesis and homology-dependent repair in mammalian cells.
Authors: Izhar, Lior1, Ziv, Omer1, Cohen, Isadora S.1, Geacintov, Nicholas E.2, Livneh, Zvi1 zvilivneh@weizmann.ac.il
Source: Proceedings of the National Academy of Sciences of the United States of America. 4/16/2013, Vol. 110 Issue 16, p6258-6259. 2p.
Subjects: DNA synthesis, Precancerous conditions, Homology (Biochemistry), Mammalian cell cycle, Single nucleotide polymorphisms, Genetic vectors, DNA damage
Abstract: The article discusses the development of a technique for simultaneous analysis of translesion DNA synthesis (TLS) and homology-dependent repair (HDR) throughout DNA lesions in mammalian genomes at a single-nucleotide formation. It says that the method is based on the portable DNA vectors insertion that bears defined site-specific DNA lesions. It states that the developed genomic assay demonstrates the tolerance of DNA damage caused by both TLS and HDR in mammalian cells.
Database: Engineering Source
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Header DbId: egs
DbLabel: Engineering Source
An: 87094311
AccessLevel: 6
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
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  Label: Title
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  Data: Genomic assay reveals tolerance of DNA damage by both translesion DNA synthesis and homology-dependent repair in mammalian cells.
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  Data: <searchLink fieldCode="AR" term="%22Izhar%2C+Lior%22">Izhar, Lior</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Ziv%2C+Omer%22">Ziv, Omer</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Cohen%2C+Isadora+S%2E%22">Cohen, Isadora S.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Geacintov%2C+Nicholas+E%2E%22">Geacintov, Nicholas E.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Livneh%2C+Zvi%22">Livneh, Zvi</searchLink><relatesTo>1</relatesTo><i> zvilivneh@weizmann.ac.il</i>
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  Data: <searchLink fieldCode="JN" term="%22Proceedings+of+the+National+Academy+of+Sciences+of+the+United+States+of+America%22">Proceedings of the National Academy of Sciences of the United States of America</searchLink>. 4/16/2013, Vol. 110 Issue 16, p6258-6259. 2p.
– Name: Subject
  Label: Subjects
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  Data: <searchLink fieldCode="DE" term="%22DNA+synthesis%22">DNA synthesis</searchLink><br /><searchLink fieldCode="DE" term="%22Precancerous+conditions%22">Precancerous conditions</searchLink><br /><searchLink fieldCode="DE" term="%22Homology+%28Biochemistry%29%22">Homology (Biochemistry)</searchLink><br /><searchLink fieldCode="DE" term="%22Mammalian+cell+cycle%22">Mammalian cell cycle</searchLink><br /><searchLink fieldCode="DE" term="%22Single+nucleotide+polymorphisms%22">Single nucleotide polymorphisms</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+vectors%22">Genetic vectors</searchLink><br /><searchLink fieldCode="DE" term="%22DNA+damage%22">DNA damage</searchLink>
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The article discusses the development of a technique for simultaneous analysis of translesion DNA synthesis (TLS) and homology-dependent repair (HDR) throughout DNA lesions in mammalian genomes at a single-nucleotide formation. It says that the method is based on the portable DNA vectors insertion that bears defined site-specific DNA lesions. It states that the developed genomic assay demonstrates the tolerance of DNA damage caused by both TLS and HDR in mammalian cells.
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1073/pnas.1216894110
    Languages:
      – Code: eng
        Text: English
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      Pagination:
        PageCount: 2
        StartPage: 6258
    Subjects:
      – SubjectFull: DNA synthesis
        Type: general
      – SubjectFull: Precancerous conditions
        Type: general
      – SubjectFull: Homology (Biochemistry)
        Type: general
      – SubjectFull: Mammalian cell cycle
        Type: general
      – SubjectFull: Single nucleotide polymorphisms
        Type: general
      – SubjectFull: Genetic vectors
        Type: general
      – SubjectFull: DNA damage
        Type: general
    Titles:
      – TitleFull: Genomic assay reveals tolerance of DNA damage by both translesion DNA synthesis and homology-dependent repair in mammalian cells.
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            NameFull: Izhar, Lior
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            NameFull: Ziv, Omer
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            NameFull: Cohen, Isadora S.
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            NameFull: Geacintov, Nicholas E.
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            NameFull: Livneh, Zvi
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            – D: 16
              M: 04
              Text: 4/16/2013
              Type: published
              Y: 2013
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              Value: 00278424
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              Value: 110
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              Value: 16
          Titles:
            – TitleFull: Proceedings of the National Academy of Sciences of the United States of America
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