Genomic assay reveals tolerance of DNA damage by both translesion DNA synthesis and homology-dependent repair in mammalian cells.
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| Title: | Genomic assay reveals tolerance of DNA damage by both translesion DNA synthesis and homology-dependent repair in mammalian cells. |
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| Authors: | Izhar, Lior1, Ziv, Omer1, Cohen, Isadora S.1, Geacintov, Nicholas E.2, Livneh, Zvi1 zvilivneh@weizmann.ac.il |
| Source: | Proceedings of the National Academy of Sciences of the United States of America. 4/16/2013, Vol. 110 Issue 16, p6258-6259. 2p. |
| Subjects: | DNA synthesis, Precancerous conditions, Homology (Biochemistry), Mammalian cell cycle, Single nucleotide polymorphisms, Genetic vectors, DNA damage |
| Abstract: | The article discusses the development of a technique for simultaneous analysis of translesion DNA synthesis (TLS) and homology-dependent repair (HDR) throughout DNA lesions in mammalian genomes at a single-nucleotide formation. It says that the method is based on the portable DNA vectors insertion that bears defined site-specific DNA lesions. It states that the developed genomic assay demonstrates the tolerance of DNA damage caused by both TLS and HDR in mammalian cells. |
| Database: | Engineering Source |
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