A one-pot two-step microwave-assisted synthesis of N1-substituted 5,6-ring-fused 2-pyridones.
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| Title: | A one-pot two-step microwave-assisted synthesis of N1-substituted 5,6-ring-fused 2-pyridones. |
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| Authors: | Radi, Marco1 marco.radi@unipr.it, Vallerini, Gian Paolo1, Petrelli, Alessia1, Vincetti, Paolo1, Costantino, Gabriele1 |
| Source: | Tetrahedron Letters: International Organ for the Rapid Publication of Preliminary Communications in Organic Chemistry. Dec2013, Vol. 54 Issue 50, p6905-6908. 4p. |
| Subjects: | Pyridone synthesis, Microwave heating, Ketones, Amines, Organic compounds, Drug development |
| Abstract: | Abstract: A fast, versatile and practical one-pot, two-step microwave-assisted protocol for the direct synthesis of N1-substituted 5,6-ring-fused 2-pyridones has been developed. The present method proved to be effective on a series of commercially available aldehydes, ketones and amines and could be profitably exploited in drug-discovery settings for the rapid identification of biologically relevant hit compounds. [Copyright &y& Elsevier] |
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| Database: | Engineering Source |
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