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Evaluation of Cefaclor in Acute Otitis Media Caused by Ampicillin-resistant H. influenzae.

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Title: Evaluation of Cefaclor in Acute Otitis Media Caused by Ampicillin-resistant H. influenzae.
Authors: Schwartz, Richard H.1,2, Rodriguez, William J.1,2, Khan, Waheed N.1,2, Brigham, Lori1,2, Ross, Sydney1,2
Source: Clinical Pediatrics. Jul1982, Vol. 21 Issue 7, p402-404. 3p.
Subject Terms: *Children's health, Cefaclor, Acute otitis media, Influenza, Pharmaceutical research, Pharmacology, Pediatrics
Abstract: Cefaclor was used to treat 13 children with acute otitis media caused by ampicillin-resistant strains of Hemophilus influenzae. The children were re-examined on days 4, 10, and 28. Pharmacologic compliance was assessed by means of a bioinhibition assay on a urine specimen obtained on days 4, 7, and 10. Nine of the 13 children had evidence by tympanogram of residual otitis media with effusion (secretory otitis media). Of these, three were noted to have a bulging, yellow or grey eardrum, which suggested an ongoing acute process. A second middle ear culture was obtained from two of the 3 children, but no pathogens were recovered. Two others had recurrence of otitis shortly after cessation of therapy. Cefaclor is an acceptable antibiotic for the treatment of ampicillin-resistant acute otitis media; but, after cefaclor therapy, some children continued to have a bulging eardrum and sterile pus in the middle ear or had recurrences of otitis soon after cessation of therapy. [ABSTRACT FROM AUTHOR]
Copyright of Clinical Pediatrics is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Education Research Complete
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  Data: Evaluation of Cefaclor in Acute Otitis Media Caused by Ampicillin-resistant H. influenzae.
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  Data: <searchLink fieldCode="JN" term="%22Clinical+Pediatrics%22">Clinical Pediatrics</searchLink>. Jul1982, Vol. 21 Issue 7, p402-404. 3p.
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  Data: *<searchLink fieldCode="DE" term="%22Children's+health%22">Children's health</searchLink><br /><searchLink fieldCode="DE" term="%22Cefaclor%22">Cefaclor</searchLink><br /><searchLink fieldCode="DE" term="%22Acute+otitis+media%22">Acute otitis media</searchLink><br /><searchLink fieldCode="DE" term="%22Influenza%22">Influenza</searchLink><br /><searchLink fieldCode="DE" term="%22Pharmaceutical+research%22">Pharmaceutical research</searchLink><br /><searchLink fieldCode="DE" term="%22Pharmacology%22">Pharmacology</searchLink><br /><searchLink fieldCode="DE" term="%22Pediatrics%22">Pediatrics</searchLink>
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  Data: Cefaclor was used to treat 13 children with acute otitis media caused by ampicillin-resistant strains of Hemophilus influenzae. The children were re-examined on days 4, 10, and 28. Pharmacologic compliance was assessed by means of a bioinhibition assay on a urine specimen obtained on days 4, 7, and 10. Nine of the 13 children had evidence by tympanogram of residual otitis media with effusion (secretory otitis media). Of these, three were noted to have a bulging, yellow or grey eardrum, which suggested an ongoing acute process. A second middle ear culture was obtained from two of the 3 children, but no pathogens were recovered. Two others had recurrence of otitis shortly after cessation of therapy. Cefaclor is an acceptable antibiotic for the treatment of ampicillin-resistant acute otitis media; but, after cefaclor therapy, some children continued to have a bulging eardrum and sterile pus in the middle ear or had recurrences of otitis soon after cessation of therapy. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Clinical Pediatrics is the property of Sage Publications Inc. and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.1177/000992288202100703
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      – Code: eng
        Text: English
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        PageCount: 3
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      – SubjectFull: Children's health
        Type: general
      – SubjectFull: Cefaclor
        Type: general
      – SubjectFull: Acute otitis media
        Type: general
      – SubjectFull: Influenza
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      – SubjectFull: Pharmaceutical research
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      – SubjectFull: Pharmacology
        Type: general
      – SubjectFull: Pediatrics
        Type: general
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      – TitleFull: Evaluation of Cefaclor in Acute Otitis Media Caused by Ampicillin-resistant H. influenzae.
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            NameFull: Schwartz, Richard H.
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            NameFull: Rodriguez, William J.
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            NameFull: Khan, Waheed N.
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            NameFull: Brigham, Lori
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            NameFull: Ross, Sydney
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            – D: 01
              M: 07
              Text: Jul1982
              Type: published
              Y: 1982
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