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Fecal Calprotectin in Predicting Relapse of Inflammatory Bowel Disease in Children and Adolescents: A Meta-Analysis and Systematic Review.

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Title: Fecal Calprotectin in Predicting Relapse of Inflammatory Bowel Disease in Children and Adolescents: A Meta-Analysis and Systematic Review.
Authors: Hu, Tingpeng (AUTHOR), Wang, Wei (AUTHOR) wangwei990314@163.com, Song, Fusheng (AUTHOR), Zhang, Wenguang (AUTHOR), Yang, Jun (AUTHOR)
Source: Pediatric Annals. Sep2023, Vol. 52 Issue 9, pe357-e362. 6p.
Abstract: The application of fecal calprotectin in the relapse of inflammatory bowel disease remains uncertain in children and adolescents. We systematically searched the common databases for eligible studies. Judgment of diagnostic accuracy included pooled sensitivity and specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and pooled area under the receiver operating characteristic curve. Ultimately, a total of 414 participants from six studies were included. The combined sensitivity, specificity, PLR, and NLR with 95% confidence intervals (CIs) were 0.85 (95% CI = 0.65 to 0.79), 0.71 (95% CI = 0.52 to 0.85), 2.95 (95% CI = 1.71 to 5.09), and 0.21 (95% CI = 0.08 to 0.51), respectively. The area under the summary receiver operating characteristic curve was 0.85, and the DOR was 14.14 (95% CI = 4.46 to 44.80). Our study showed that fecal calprotectin as a biomarker to predict the clinical relapse of inflammatory bowel disease during remission in children and adolescents is effective and worth applying. [Pediatr Ann. 2023;52(9):e357–e362.] [ABSTRACT FROM AUTHOR]
Copyright of Pediatric Annals is the property of SLACK Incorporated and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Education Research Complete
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PubType: Academic Journal
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  Data: Fecal Calprotectin in Predicting Relapse of Inflammatory Bowel Disease in Children and Adolescents: A Meta-Analysis and Systematic Review.
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  Data: <searchLink fieldCode="AR" term="%22Hu%2C+Tingpeng%22">Hu, Tingpeng</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Wang%2C+Wei%22">Wang, Wei</searchLink> (AUTHOR)<i> wangwei990314@163.com</i><br /><searchLink fieldCode="AR" term="%22Song%2C+Fusheng%22">Song, Fusheng</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Zhang%2C+Wenguang%22">Zhang, Wenguang</searchLink> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Yang%2C+Jun%22">Yang, Jun</searchLink> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Pediatric+Annals%22">Pediatric Annals</searchLink>. Sep2023, Vol. 52 Issue 9, pe357-e362. 6p.
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: The application of fecal calprotectin in the relapse of inflammatory bowel disease remains uncertain in children and adolescents. We systematically searched the common databases for eligible studies. Judgment of diagnostic accuracy included pooled sensitivity and specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and pooled area under the receiver operating characteristic curve. Ultimately, a total of 414 participants from six studies were included. The combined sensitivity, specificity, PLR, and NLR with 95% confidence intervals (CIs) were 0.85 (95% CI = 0.65 to 0.79), 0.71 (95% CI = 0.52 to 0.85), 2.95 (95% CI = 1.71 to 5.09), and 0.21 (95% CI = 0.08 to 0.51), respectively. The area under the summary receiver operating characteristic curve was 0.85, and the DOR was 14.14 (95% CI = 4.46 to 44.80). Our study showed that fecal calprotectin as a biomarker to predict the clinical relapse of inflammatory bowel disease during remission in children and adolescents is effective and worth applying. [Pediatr Ann. 2023;52(9):e357–e362.] [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: <i>Copyright of Pediatric Annals is the property of SLACK Incorporated and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.3928/19382359-20230720-04
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      – TitleFull: Fecal Calprotectin in Predicting Relapse of Inflammatory Bowel Disease in Children and Adolescents: A Meta-Analysis and Systematic Review.
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              M: 09
              Text: Sep2023
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              Y: 2023
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