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BDNF Val66Met polymorphism moderates negative symptom expression of bully victimization through resilience in Taiwanese youth.

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Title: BDNF Val66Met polymorphism moderates negative symptom expression of bully victimization through resilience in Taiwanese youth.
Authors: Lee, Chih-Ting1 (AUTHOR), Lin, Chung-Ying2 (AUTHOR), Strong, Carol3 (AUTHOR), Chang, Yun-Hsuan4,5,6 (AUTHOR), Lin, Yi-Ching7 (AUTHOR), Hsieh, Yi-Ping8 (AUTHOR), Lin, Yu-Fang9 (AUTHOR), Tsai, Meng-Che9,10,11 (AUTHOR) ache93@yahoo.com.tw
Source: European Journal of Developmental Psychology. Mar2024, Vol. 21 Issue 2, p236-257. 22p.
Subject Terms: *Psychological resilience, *Bullying, *School bullying, Taiwanese people, Brain-derived neurotrophic factor, Crime victims, Genotype-environment interaction
Abstract: Bully victimization is known to cause adverse psychological outcomes; however, resilience may mitigate the more adverse effects. Little is known regarding the role played by BDNF Val66Met polymorphism in youth resilience against psychological harm caused by bully victimization. In this cross-sectional study, a community sample of 598 participants (Mage = 20.1 ± 1.4 years, 48.8% males) completed the questionnaire on bully victimization, resilience, and psychological symptoms. Salivary genomic DNA was genotyped for the BDNF Val66Met polymorphism. A path analysis was used to test the mediating role of resilience in the association between bully victimization and psychological symptoms. Furthermore, the BDNF genotype was added to the model to explore its moderating effects on the mediating role of resilience in the path with 5000 bootstrapped samplings using SPSS PROCESS Macro. Results revealed a significant indirect effect via resilience that accounted for 17.2% of the association between bully victimization and psychological symptoms. While the Val66Met polymorphism interacted with bully victimization to predict resilience scores, bully victimization was more strongly associated with poor resilience (F = 4.59, p = 0.03) in subjects with the Met/Met genotype (β=-3.22, p < 0.001), as compared to participants with other genotypes (β=-1.33, p = 0.051). Findings suggest a gene-environment interaction effect on psychological resilience in bully-victimized youth. [ABSTRACT FROM AUTHOR]
Copyright of European Journal of Developmental Psychology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Data: BDNF Val66Met polymorphism moderates negative symptom expression of bully victimization through resilience in Taiwanese youth.
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  Data: &lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lee%2C+Chih-Ting%22&quot;&gt;Lee, Chih-Ting&lt;/searchLink&gt;&lt;relatesTo&gt;1&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lin%2C+Chung-Ying%22&quot;&gt;Lin, Chung-Ying&lt;/searchLink&gt;&lt;relatesTo&gt;2&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Strong%2C+Carol%22&quot;&gt;Strong, Carol&lt;/searchLink&gt;&lt;relatesTo&gt;3&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Chang%2C+Yun-Hsuan%22&quot;&gt;Chang, Yun-Hsuan&lt;/searchLink&gt;&lt;relatesTo&gt;4,5,6&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lin%2C+Yi-Ching%22&quot;&gt;Lin, Yi-Ching&lt;/searchLink&gt;&lt;relatesTo&gt;7&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Hsieh%2C+Yi-Ping%22&quot;&gt;Hsieh, Yi-Ping&lt;/searchLink&gt;&lt;relatesTo&gt;8&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Lin%2C+Yu-Fang%22&quot;&gt;Lin, Yu-Fang&lt;/searchLink&gt;&lt;relatesTo&gt;9&lt;/relatesTo&gt; (AUTHOR)&lt;br /&gt;&lt;searchLink fieldCode=&quot;AR&quot; term=&quot;%22Tsai%2C+Meng-Che%22&quot;&gt;Tsai, Meng-Che&lt;/searchLink&gt;&lt;relatesTo&gt;9,10,11&lt;/relatesTo&gt; (AUTHOR)&lt;i&gt; ache93@yahoo.com.tw&lt;/i&gt;
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  Data: &lt;searchLink fieldCode=&quot;JN&quot; term=&quot;%22European+Journal+of+Developmental+Psychology%22&quot;&gt;European Journal of Developmental Psychology&lt;/searchLink&gt;. Mar2024, Vol. 21 Issue 2, p236-257. 22p.
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  Data: *&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Psychological+resilience%22&quot;&gt;Psychological resilience&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Bullying%22&quot;&gt;Bullying&lt;/searchLink&gt;&lt;br /&gt;*&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22School+bullying%22&quot;&gt;School bullying&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Taiwanese+people%22&quot;&gt;Taiwanese people&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Brain-derived+neurotrophic+factor%22&quot;&gt;Brain-derived neurotrophic factor&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Crime+victims%22&quot;&gt;Crime victims&lt;/searchLink&gt;&lt;br /&gt;&lt;searchLink fieldCode=&quot;DE&quot; term=&quot;%22Genotype-environment+interaction%22&quot;&gt;Genotype-environment interaction&lt;/searchLink&gt;
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Bully victimization is known to cause adverse psychological outcomes; however, resilience may mitigate the more adverse effects. Little is known regarding the role played by BDNF Val66Met polymorphism in youth resilience against psychological harm caused by bully victimization. In this cross-sectional study, a community sample of 598 participants (Mage = 20.1 &#177; 1.4 years, 48.8% males) completed the questionnaire on bully victimization, resilience, and psychological symptoms. Salivary genomic DNA was genotyped for the BDNF Val66Met polymorphism. A path analysis was used to test the mediating role of resilience in the association between bully victimization and psychological symptoms. Furthermore, the BDNF genotype was added to the model to explore its moderating effects on the mediating role of resilience in the path with 5000 bootstrapped samplings using SPSS PROCESS Macro. Results revealed a significant indirect effect via resilience that accounted for 17.2% of the association between bully victimization and psychological symptoms. While the Val66Met polymorphism interacted with bully victimization to predict resilience scores, bully victimization was more strongly associated with poor resilience (F = 4.59, p = 0.03) in subjects with the Met/Met genotype (β=-3.22, p &lt; 0.001), as compared to participants with other genotypes (β=-1.33, p = 0.051). Findings suggest a gene-environment interaction effect on psychological resilience in bully-victimized youth. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
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  Data: &lt;i&gt;Copyright of European Journal of Developmental Psychology is the property of Taylor &amp; Francis Ltd and its content may not be copied or emailed to multiple sites without the copyright holder&#39;s express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.&lt;/i&gt; (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1080/17405629.2024.2315765
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 22
        StartPage: 236
    Subjects:
      – SubjectFull: Psychological resilience
        Type: general
      – SubjectFull: Bullying
        Type: general
      – SubjectFull: School bullying
        Type: general
      – SubjectFull: Taiwanese people
        Type: general
      – SubjectFull: Brain-derived neurotrophic factor
        Type: general
      – SubjectFull: Crime victims
        Type: general
      – SubjectFull: Genotype-environment interaction
        Type: general
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      – TitleFull: BDNF Val66Met polymorphism moderates negative symptom expression of bully victimization through resilience in Taiwanese youth.
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            NameFull: Lee, Chih-Ting
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            NameFull: Lin, Chung-Ying
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            NameFull: Strong, Carol
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            NameFull: Chang, Yun-Hsuan
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            NameFull: Lin, Yi-Ching
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            – D: 01
              M: 03
              Text: Mar2024
              Type: published
              Y: 2024
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            – TitleFull: European Journal of Developmental Psychology
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