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Translating the Power of Precision Medicine Into the World of Communication Disorders.

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Title: Translating the Power of Precision Medicine Into the World of Communication Disorders.
Authors: Peter, Beate1 Beate.Peter@asu.edu, Davis, Jennifer1, Bruce, Laurel1, Finestack, Lizbeth2, Kornelis, Miriam2, Eng, Linda1, Kim, Yookyung1, Scherer, Nancy1, Potter, Nancy3, VanDam, Mark3, Thompson, Lauren3, Loveall, Susan4, Stoel-Gammon, Carol5, Raaz, Caitlin6, Armstrong-Heimsoth, Amy7, Buckley, Sue8,9
Source: Journal of Speech, Language & Hearing Research. Nov2025, Vol. 68 Issue 11, p5174-5189. 16p.
Subject Terms: *Psychological resilience, *Down syndrome, *Dyslexia, *Speech-language pathology, *Communication, *Language disorders, Treatment of communicative disorders, Therapeutics, Translations, Galactosemia, Communicative disorders in children, Early diagnosis, Genetics, Phenotypes, Genotypes
Abstract: Purpose: Precision medicine is an emerging approach to medical diagnostics, prognostics, and intervention that takes an individual's genetic, environmental, and lifestyle-related profile into account to improve outcomes in medical conditions such as diabetes and cancer. Here, we explore how principles of precision medicine can be leveraged in the field of speech-language pathology. Method: We reviewed the literature and report the following: (a) brief introduction to precision medicine, (b) review of a prophylactic intervention for infants at a genetic risk for speech/language disorders, (c) potential approaches to leveraging endophenotypes for individualized interventions in dyslexia, and (d) identified barriers and opportunities for incorporating precision medicine more broadly into the field of communication sciences and disorders. Results: An established example of a prophylactic intervention based on known genotype-phenotype associations is Babble Boot Camp (BBC), a novel personalized and proactive intervention designed to foster precursor and early communication skills of infants at a predictable genetic risk. We describe a successful clinical trial of BBC for infants at a genetic risk due to classic galactosemia and pilot trials for infants with Down syndrome. An experimental example of personalization is addressing the information processing mode shared by some individuals with dyslexia, namely, diminished sensory gating. Conclusions: To implement principles of precision medicine in disorders of spoken and written communication more broadly, novel ways of identifying young children at risk are needed. As more genotype-phenotype discoveries and gene therapies come online, training in genetics can equip clinicians to recognize signs of a genetic disorder, make appropriate referrals, and personalize therapeutic approaches. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Speech, Language & Hearing Research is the property of American Speech-Language-Hearing Association and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Education Research Complete
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  Data: Translating the Power of Precision Medicine Into the World of Communication Disorders.
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  Data: <searchLink fieldCode="AR" term="%22Peter%2C+Beate%22">Peter, Beate</searchLink><relatesTo>1</relatesTo><i> Beate.Peter@asu.edu</i><br /><searchLink fieldCode="AR" term="%22Davis%2C+Jennifer%22">Davis, Jennifer</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Bruce%2C+Laurel%22">Bruce, Laurel</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Finestack%2C+Lizbeth%22">Finestack, Lizbeth</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Kornelis%2C+Miriam%22">Kornelis, Miriam</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Eng%2C+Linda%22">Eng, Linda</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Kim%2C+Yookyung%22">Kim, Yookyung</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Scherer%2C+Nancy%22">Scherer, Nancy</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Potter%2C+Nancy%22">Potter, Nancy</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22VanDam%2C+Mark%22">VanDam, Mark</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Thompson%2C+Lauren%22">Thompson, Lauren</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Loveall%2C+Susan%22">Loveall, Susan</searchLink><relatesTo>4</relatesTo><br /><searchLink fieldCode="AR" term="%22Stoel-Gammon%2C+Carol%22">Stoel-Gammon, Carol</searchLink><relatesTo>5</relatesTo><br /><searchLink fieldCode="AR" term="%22Raaz%2C+Caitlin%22">Raaz, Caitlin</searchLink><relatesTo>6</relatesTo><br /><searchLink fieldCode="AR" term="%22Armstrong-Heimsoth%2C+Amy%22">Armstrong-Heimsoth, Amy</searchLink><relatesTo>7</relatesTo><br /><searchLink fieldCode="AR" term="%22Buckley%2C+Sue%22">Buckley, Sue</searchLink><relatesTo>8,9</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Speech%2C+Language+%26+Hearing+Research%22">Journal of Speech, Language & Hearing Research</searchLink>. Nov2025, Vol. 68 Issue 11, p5174-5189. 16p.
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  Data: *<searchLink fieldCode="DE" term="%22Psychological+resilience%22">Psychological resilience</searchLink><br />*<searchLink fieldCode="DE" term="%22Down+syndrome%22">Down syndrome</searchLink><br />*<searchLink fieldCode="DE" term="%22Dyslexia%22">Dyslexia</searchLink><br />*<searchLink fieldCode="DE" term="%22Speech-language+pathology%22">Speech-language pathology</searchLink><br />*<searchLink fieldCode="DE" term="%22Communication%22">Communication</searchLink><br />*<searchLink fieldCode="DE" term="%22Language+disorders%22">Language disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+of+communicative+disorders%22">Treatment of communicative disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Therapeutics%22">Therapeutics</searchLink><br /><searchLink fieldCode="DE" term="%22Translations%22">Translations</searchLink><br /><searchLink fieldCode="DE" term="%22Galactosemia%22">Galactosemia</searchLink><br /><searchLink fieldCode="DE" term="%22Communicative+disorders+in+children%22">Communicative disorders in children</searchLink><br /><searchLink fieldCode="DE" term="%22Early+diagnosis%22">Early diagnosis</searchLink><br /><searchLink fieldCode="DE" term="%22Genetics%22">Genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Phenotypes%22">Phenotypes</searchLink><br /><searchLink fieldCode="DE" term="%22Genotypes%22">Genotypes</searchLink>
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  Data: Purpose: Precision medicine is an emerging approach to medical diagnostics, prognostics, and intervention that takes an individual's genetic, environmental, and lifestyle-related profile into account to improve outcomes in medical conditions such as diabetes and cancer. Here, we explore how principles of precision medicine can be leveraged in the field of speech-language pathology. Method: We reviewed the literature and report the following: (a) brief introduction to precision medicine, (b) review of a prophylactic intervention for infants at a genetic risk for speech/language disorders, (c) potential approaches to leveraging endophenotypes for individualized interventions in dyslexia, and (d) identified barriers and opportunities for incorporating precision medicine more broadly into the field of communication sciences and disorders. Results: An established example of a prophylactic intervention based on known genotype-phenotype associations is Babble Boot Camp (BBC), a novel personalized and proactive intervention designed to foster precursor and early communication skills of infants at a predictable genetic risk. We describe a successful clinical trial of BBC for infants at a genetic risk due to classic galactosemia and pilot trials for infants with Down syndrome. An experimental example of personalization is addressing the information processing mode shared by some individuals with dyslexia, namely, diminished sensory gating. Conclusions: To implement principles of precision medicine in disorders of spoken and written communication more broadly, novel ways of identifying young children at risk are needed. As more genotype-phenotype discoveries and gene therapies come online, training in genetics can equip clinicians to recognize signs of a genetic disorder, make appropriate referrals, and personalize therapeutic approaches. [ABSTRACT FROM AUTHOR]
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  Data: <i>Copyright of Journal of Speech, Language & Hearing Research is the property of American Speech-Language-Hearing Association and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=ehh&AN=189241800
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        Value: 10.1044/2025_JSLHR-25-00077
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