Neuroimaging Advances in Brain Function of Laryngeal Dystonia: A Systematic Review.
Saved in:
| Title: | Neuroimaging Advances in Brain Function of Laryngeal Dystonia: A Systematic Review. |
|---|---|
| Authors: | Hu, Yuanjia1, Xing, Lu1,2, Wu, Shengtao3, Zhuang, Peiyun1,2 peiyunzhuang@163.com |
| Source: | Journal of Speech, Language & Hearing Research. Apr2026, Vol. 69 Issue 4, p1631-1642. 12p. |
| Subject Terms: | *Brain, Brain physiology, Brain anatomy, Research funding, Sensorimotor integration, Magnetic resonance imaging, Systematic reviews, MEDLINE, Gray matter (Nerve tissue), Thalamus, White matter (Nerve tissue), Neuroradiology, Online information services, Cerebellum, Data analysis software, Spasmodic dysphonia |
| Abstract: | Purpose: This study aims to review neuroimaging research on brain function in laryngeal dystonia (LD), summarize current evidence on its pathophysiological mechanisms, and highlight directions for future investigation. Method: PubMed, Scopus, and Web of Science Core Collection were searched from database inception to November 2025. Two reviewers independently screened studies, extracted data, and assessed study quality using the Newcastle--Ottawa Scale. Eligible studies were synthesized through systematic review and visual analysis. Results: A total of 33 studies were included. These studies employed imaging techniques such as functional magnetic resonance imaging and voxel-based morphometry to identify abnormalities in patients with LD. Structurally, key findings include gray matter alterations in sensorimotor areas, reduced thalamic volume, and impaired white matter integrity. Functionally, this manifests as sensorimotor integration dysfunction (characterized by M1/S1 and cerebellar hypoactivation alongside pallidal and thalamic hyperactivation) and network decoupling (e.g., weakened M1-S1 connectivity). Conclusions: The pathological mechanism of LD is a complex network imbalance involving the core "cortico-basal ganglia-thalamo-cerebellar" loop, driven primarily by sensorimotor integration dysfunction. Current research is limited in quantity and suffers from significant methodological heterogeneity. Future studies should further clarify the functional interactions among brain regions and their relationship with clinical symptoms, thereby providing a theoretical basis for the development of targeted therapies. Supplemental Material: https://doi.org/10.23641/asha.31329103 [ABSTRACT FROM AUTHOR] |
| Copyright of Journal of Speech, Language & Hearing Research is the property of American Speech-Language-Hearing Association and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Education Research Complete |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
|---|---|
| Header | DbId: ehh DbLabel: Education Research Complete An: 192982182 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
| IllustrationInfo | |
| Items | – Name: Title Label: Title Group: Ti Data: Neuroimaging Advances in Brain Function of Laryngeal Dystonia: A Systematic Review. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Hu%2C+Yuanjia%22">Hu, Yuanjia</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Xing%2C+Lu%22">Xing, Lu</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Wu%2C+Shengtao%22">Wu, Shengtao</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Zhuang%2C+Peiyun%22">Zhuang, Peiyun</searchLink><relatesTo>1,2</relatesTo><i> peiyunzhuang@163.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Journal+of+Speech%2C+Language+%26+Hearing+Research%22">Journal of Speech, Language & Hearing Research</searchLink>. Apr2026, Vol. 69 Issue 4, p1631-1642. 12p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22Brain%22">Brain</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+physiology%22">Brain physiology</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+anatomy%22">Brain anatomy</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Sensorimotor+integration%22">Sensorimotor integration</searchLink><br /><searchLink fieldCode="DE" term="%22Magnetic+resonance+imaging%22">Magnetic resonance imaging</searchLink><br /><searchLink fieldCode="DE" term="%22Systematic+reviews%22">Systematic reviews</searchLink><br /><searchLink fieldCode="DE" term="%22MEDLINE%22">MEDLINE</searchLink><br /><searchLink fieldCode="DE" term="%22Gray+matter+%28Nerve+tissue%29%22">Gray matter (Nerve tissue)</searchLink><br /><searchLink fieldCode="DE" term="%22Thalamus%22">Thalamus</searchLink><br /><searchLink fieldCode="DE" term="%22White+matter+%28Nerve+tissue%29%22">White matter (Nerve tissue)</searchLink><br /><searchLink fieldCode="DE" term="%22Neuroradiology%22">Neuroradiology</searchLink><br /><searchLink fieldCode="DE" term="%22Online+information+services%22">Online information services</searchLink><br /><searchLink fieldCode="DE" term="%22Cerebellum%22">Cerebellum</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Spasmodic+dysphonia%22">Spasmodic dysphonia</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: This study aims to review neuroimaging research on brain function in laryngeal dystonia (LD), summarize current evidence on its pathophysiological mechanisms, and highlight directions for future investigation. Method: PubMed, Scopus, and Web of Science Core Collection were searched from database inception to November 2025. Two reviewers independently screened studies, extracted data, and assessed study quality using the Newcastle--Ottawa Scale. Eligible studies were synthesized through systematic review and visual analysis. Results: A total of 33 studies were included. These studies employed imaging techniques such as functional magnetic resonance imaging and voxel-based morphometry to identify abnormalities in patients with LD. Structurally, key findings include gray matter alterations in sensorimotor areas, reduced thalamic volume, and impaired white matter integrity. Functionally, this manifests as sensorimotor integration dysfunction (characterized by M1/S1 and cerebellar hypoactivation alongside pallidal and thalamic hyperactivation) and network decoupling (e.g., weakened M1-S1 connectivity). Conclusions: The pathological mechanism of LD is a complex network imbalance involving the core "cortico-basal ganglia-thalamo-cerebellar" loop, driven primarily by sensorimotor integration dysfunction. Current research is limited in quantity and suffers from significant methodological heterogeneity. Future studies should further clarify the functional interactions among brain regions and their relationship with clinical symptoms, thereby providing a theoretical basis for the development of targeted therapies. Supplemental Material: https://doi.org/10.23641/asha.31329103 [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Journal of Speech, Language & Hearing Research is the property of American Speech-Language-Hearing Association and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=ehh&AN=192982182 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1044/2025_JSLHR-25-00663 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 1631 Subjects: – SubjectFull: Brain Type: general – SubjectFull: Brain physiology Type: general – SubjectFull: Brain anatomy Type: general – SubjectFull: Research funding Type: general – SubjectFull: Sensorimotor integration Type: general – SubjectFull: Magnetic resonance imaging Type: general – SubjectFull: Systematic reviews Type: general – SubjectFull: MEDLINE Type: general – SubjectFull: Gray matter (Nerve tissue) Type: general – SubjectFull: Thalamus Type: general – SubjectFull: White matter (Nerve tissue) Type: general – SubjectFull: Neuroradiology Type: general – SubjectFull: Online information services Type: general – SubjectFull: Cerebellum Type: general – SubjectFull: Data analysis software Type: general – SubjectFull: Spasmodic dysphonia Type: general Titles: – TitleFull: Neuroimaging Advances in Brain Function of Laryngeal Dystonia: A Systematic Review. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Hu, Yuanjia – PersonEntity: Name: NameFull: Xing, Lu – PersonEntity: Name: NameFull: Wu, Shengtao – PersonEntity: Name: NameFull: Zhuang, Peiyun IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 04 Text: Apr2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 10924388 Numbering: – Type: volume Value: 69 – Type: issue Value: 4 Titles: – TitleFull: Journal of Speech, Language & Hearing Research Type: main |
| ResultId | 1 |
