A Comparison of Four Selected Acoustic Measures in Detecting Voice Quality Changes With Botulinum Toxin Treatment in Adductor-Type Laryngeal Dystonia.
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| Title: | A Comparison of Four Selected Acoustic Measures in Detecting Voice Quality Changes With Botulinum Toxin Treatment in Adductor-Type Laryngeal Dystonia. |
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| Authors: | Pierce, Jenny L.1 jenny.pierce@hsc.utah.edu, Dwenger, Kaitlyn1,2, Sharma, Anuja1, Jennings, Skyler G.2, Smith, Marshall1, Barkmeier-Kraemer, Julie1,2 |
| Source: | American Journal of Speech-Language Pathology. May2026, Vol. 35 Issue 3, p901-922. 22p. |
| Subject Terms: | *Comparative studies, *Inter-observer reliability, Pearson correlation (Statistics), Research funding, T-test (Statistics), Research evaluation, Treatment effectiveness, Descriptive statistics, Physiological aspects of speech, Sound recordings, Botulinum toxin, Intraclass correlation, Human voice, Data analysis software, Confidence intervals, Health outcome assessment, Spasmodic dysphonia, Sensitivity & specificity (Statistics) |
| Geographic Terms: | Utah |
| Abstract: | Purpose: Adductor-type laryngeal dystonia (AdLD) is a voice disorder with substantial negative effects. The current standard treatment is botulinum toxin (BoNT) injections, with novel treatments on the horizon. The aim of this study was to determine the sensitivity of selected acoustic measures to measure voice quality change from pre-BoNT to the participants' perceived maximum benefit from BoNT. Method: Twenty-three participants with AdLD underwent acoustic recordings at pre-BoNT and a subset of 12 participants during the participants' perceived maximum benefit from BoNT. Four acoustic measures were employed: (a) cepstral peak prominence-smoothed (CPPS) estimated in Praat, (b) the cepstral spectral index of dysphonia (CSID), (c) percent creak (%creak), and (d) sharpness (a measure of vocal strain). The four measures were also compared with listener ratings and Voice Handicap Index (VHI-10) scores. Results: The CPPS, CSID, and %creak measures showed significant treatmentrelated change (p < .001). Effect sizes were large for CPPS (.97) and moderate for CSID (.68) and %creak (.62). Correlations with listener ratings were strong for CPPS (-.66), moderate for CSID (.58) and %creak (.48), and very weak for sharpness (.19). Correlations with VHI-10 were moderate for CPPS (-.53), weak for %creak (.36) and CSID (.33), and very weak for sharpness (.19). Conclusions: Based on these results, CPPS, CSID, and %creak showed utility in assessing voice quality change from pre- to post-BoNT treatment in those with AdLD, with some differences across measures. Future research with novel treatments for AdLD may benefit from utilization of these measures including comparison of effect sizes with degree of improvement from BoNT outcomes. [ABSTRACT FROM AUTHOR] |
| Copyright of American Journal of Speech-Language Pathology is the property of American Speech-Language-Hearing Association and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | Education Research Complete |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: ehh DbLabel: Education Research Complete An: 193560201 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: A Comparison of Four Selected Acoustic Measures in Detecting Voice Quality Changes With Botulinum Toxin Treatment in Adductor-Type Laryngeal Dystonia. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Pierce%2C+Jenny+L%2E%22">Pierce, Jenny L.</searchLink><relatesTo>1</relatesTo><i> jenny.pierce@hsc.utah.edu</i><br /><searchLink fieldCode="AR" term="%22Dwenger%2C+Kaitlyn%22">Dwenger, Kaitlyn</searchLink><relatesTo>1,2</relatesTo><br /><searchLink fieldCode="AR" term="%22Sharma%2C+Anuja%22">Sharma, Anuja</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Jennings%2C+Skyler+G%2E%22">Jennings, Skyler G.</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Smith%2C+Marshall%22">Smith, Marshall</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Barkmeier-Kraemer%2C+Julie%22">Barkmeier-Kraemer, Julie</searchLink><relatesTo>1,2</relatesTo> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22American+Journal+of+Speech-Language+Pathology%22">American Journal of Speech-Language Pathology</searchLink>. May2026, Vol. 35 Issue 3, p901-922. 22p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22Comparative+studies%22">Comparative studies</searchLink><br />*<searchLink fieldCode="DE" term="%22Inter-observer+reliability%22">Inter-observer reliability</searchLink><br /><searchLink fieldCode="DE" term="%22Pearson+correlation+%28Statistics%29%22">Pearson correlation (Statistics)</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22T-test+%28Statistics%29%22">T-test (Statistics)</searchLink><br /><searchLink fieldCode="DE" term="%22Research+evaluation%22">Research evaluation</searchLink><br /><searchLink fieldCode="DE" term="%22Treatment+effectiveness%22">Treatment effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22Descriptive+statistics%22">Descriptive statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Physiological+aspects+of+speech%22">Physiological aspects of speech</searchLink><br /><searchLink fieldCode="DE" term="%22Sound+recordings%22">Sound recordings</searchLink><br /><searchLink fieldCode="DE" term="%22Botulinum+toxin%22">Botulinum toxin</searchLink><br /><searchLink fieldCode="DE" term="%22Intraclass+correlation%22">Intraclass correlation</searchLink><br /><searchLink fieldCode="DE" term="%22Human+voice%22">Human voice</searchLink><br /><searchLink fieldCode="DE" term="%22Data+analysis+software%22">Data analysis software</searchLink><br /><searchLink fieldCode="DE" term="%22Confidence+intervals%22">Confidence intervals</searchLink><br /><searchLink fieldCode="DE" term="%22Health+outcome+assessment%22">Health outcome assessment</searchLink><br /><searchLink fieldCode="DE" term="%22Spasmodic+dysphonia%22">Spasmodic dysphonia</searchLink><br /><searchLink fieldCode="DE" term="%22Sensitivity+%26+specificity+%28Statistics%29%22">Sensitivity & specificity (Statistics)</searchLink> – Name: SubjectGeographic Label: Geographic Terms Group: Su Data: <searchLink fieldCode="DE" term="%22Utah%22">Utah</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Purpose: Adductor-type laryngeal dystonia (AdLD) is a voice disorder with substantial negative effects. The current standard treatment is botulinum toxin (BoNT) injections, with novel treatments on the horizon. The aim of this study was to determine the sensitivity of selected acoustic measures to measure voice quality change from pre-BoNT to the participants' perceived maximum benefit from BoNT. Method: Twenty-three participants with AdLD underwent acoustic recordings at pre-BoNT and a subset of 12 participants during the participants' perceived maximum benefit from BoNT. Four acoustic measures were employed: (a) cepstral peak prominence-smoothed (CPPS) estimated in Praat, (b) the cepstral spectral index of dysphonia (CSID), (c) percent creak (%creak), and (d) sharpness (a measure of vocal strain). The four measures were also compared with listener ratings and Voice Handicap Index (VHI-10) scores. Results: The CPPS, CSID, and %creak measures showed significant treatmentrelated change (p < .001). Effect sizes were large for CPPS (.97) and moderate for CSID (.68) and %creak (.62). Correlations with listener ratings were strong for CPPS (-.66), moderate for CSID (.58) and %creak (.48), and very weak for sharpness (.19). Correlations with VHI-10 were moderate for CPPS (-.53), weak for %creak (.36) and CSID (.33), and very weak for sharpness (.19). Conclusions: Based on these results, CPPS, CSID, and %creak showed utility in assessing voice quality change from pre- to post-BoNT treatment in those with AdLD, with some differences across measures. Future research with novel treatments for AdLD may benefit from utilization of these measures including comparison of effect sizes with degree of improvement from BoNT outcomes. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of American Journal of Speech-Language Pathology is the property of American Speech-Language-Hearing Association and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1044/2025_AJSLP-25-00143 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 22 StartPage: 901 Subjects: – SubjectFull: Comparative studies Type: general – SubjectFull: Inter-observer reliability Type: general – SubjectFull: Pearson correlation (Statistics) Type: general – SubjectFull: Research funding Type: general – SubjectFull: T-test (Statistics) Type: general – SubjectFull: Research evaluation Type: general – SubjectFull: Treatment effectiveness Type: general – SubjectFull: Descriptive statistics Type: general – SubjectFull: Physiological aspects of speech Type: general – SubjectFull: Sound recordings Type: general – SubjectFull: Botulinum toxin Type: general – SubjectFull: Intraclass correlation Type: general – SubjectFull: Human voice Type: general – SubjectFull: Data analysis software Type: general – SubjectFull: Confidence intervals Type: general – SubjectFull: Health outcome assessment Type: general – SubjectFull: Spasmodic dysphonia Type: general – SubjectFull: Sensitivity & specificity (Statistics) Type: general – SubjectFull: Utah Type: general Titles: – TitleFull: A Comparison of Four Selected Acoustic Measures in Detecting Voice Quality Changes With Botulinum Toxin Treatment in Adductor-Type Laryngeal Dystonia. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Pierce, Jenny L. – PersonEntity: Name: NameFull: Dwenger, Kaitlyn – PersonEntity: Name: NameFull: Sharma, Anuja – PersonEntity: Name: NameFull: Jennings, Skyler G. – PersonEntity: Name: NameFull: Smith, Marshall – PersonEntity: Name: NameFull: Barkmeier-Kraemer, Julie IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: May2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 10580360 Numbering: – Type: volume Value: 35 – Type: issue Value: 3 Titles: – TitleFull: American Journal of Speech-Language Pathology Type: main |
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