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Chronic Stimulation-Induced Changes in the Rodent Thyroarytenoid Muscle.

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Title: Chronic Stimulation-Induced Changes in the Rodent Thyroarytenoid Muscle.
Authors: McMullen, Colleen A.1 cmcmu2@email.uky.edu, Butterfield, Timothy A.1, Dietrich, Maria1, Andreatta, Richard D.1, Andrade, Francisco H.1, Fry, Lisa2, Stemple, Joseph C.1
Source: Journal of Speech, Language & Hearing Research. Jun2011, Vol. 54 Issue 3, p845-853. 9p. 4 Color Photographs, 1 Chart.
Subject Terms: *Statistical correlation, *Data analysis, Voice disorder treatment, Analysis of variance, Animal experimentation, Biological models, Electric stimulation, Immunohistochemistry, Rats, Research funding, Statistics, Vocal cords
Abstract: Purpose: Therapies for certain voice disorders purport principles of skeletal muscle rehabilitation to increase muscle mass, strength, and endurance. However, applicability of limb muscle rehabilitation to the laryngeal muscles has not been tested. In this study, the authors examined the feasibility of the rat thyroarytenoid muscle to remodel as a consequence of increased activity instantiated through chronic electrical stimulation. Method: Twenty adult Sprague-Dawley rats (Rattus norvegicus), assigned to a 1-week or 2-week stimulation group, were implanted with a nerve cuff electrode placed around the right recurrent laryngeal nerve and were fitted with a head connector. All animals were placed under anesthesia twice a day for 1 hr each time. Following the training, rats were killed, and thyroarytenoid muscles were isolated for histology and immunohistochemistry. Results: Mean muscle fiber area decreased, neuromuscular junction density increased, mitochondrial content increased qualitatively, and glycogen-positive fibers increased, demonstrating exercise-induced changes similar to those seen in limb muscles after endurance training. Conclusion: Rat thyroarytenoid muscles are capable of remodeling in response to chronic electrical stimulation. [ABSTRACT FROM AUTHOR]
Copyright of Journal of Speech, Language & Hearing Research is the property of American Speech-Language-Hearing Association and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
Database: Education Research Complete
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  Data: Chronic Stimulation-Induced Changes in the Rodent Thyroarytenoid Muscle.
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  Data: <searchLink fieldCode="AR" term="%22McMullen%2C+Colleen+A%2E%22">McMullen, Colleen A.</searchLink><relatesTo>1</relatesTo><i> cmcmu2@email.uky.edu</i><br /><searchLink fieldCode="AR" term="%22Butterfield%2C+Timothy+A%2E%22">Butterfield, Timothy A.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Dietrich%2C+Maria%22">Dietrich, Maria</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Andreatta%2C+Richard+D%2E%22">Andreatta, Richard D.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Andrade%2C+Francisco+H%2E%22">Andrade, Francisco H.</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Fry%2C+Lisa%22">Fry, Lisa</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Stemple%2C+Joseph+C%2E%22">Stemple, Joseph C.</searchLink><relatesTo>1</relatesTo>
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  Data: <searchLink fieldCode="JN" term="%22Journal+of+Speech%2C+Language+%26+Hearing+Research%22">Journal of Speech, Language & Hearing Research</searchLink>. Jun2011, Vol. 54 Issue 3, p845-853. 9p. 4 Color Photographs, 1 Chart.
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  Data: *<searchLink fieldCode="DE" term="%22Statistical+correlation%22">Statistical correlation</searchLink><br />*<searchLink fieldCode="DE" term="%22Data+analysis%22">Data analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Voice+disorder+treatment%22">Voice disorder treatment</searchLink><br /><searchLink fieldCode="DE" term="%22Analysis+of+variance%22">Analysis of variance</searchLink><br /><searchLink fieldCode="DE" term="%22Animal+experimentation%22">Animal experimentation</searchLink><br /><searchLink fieldCode="DE" term="%22Biological+models%22">Biological models</searchLink><br /><searchLink fieldCode="DE" term="%22Electric+stimulation%22">Electric stimulation</searchLink><br /><searchLink fieldCode="DE" term="%22Immunohistochemistry%22">Immunohistochemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Rats%22">Rats</searchLink><br /><searchLink fieldCode="DE" term="%22Research+funding%22">Research funding</searchLink><br /><searchLink fieldCode="DE" term="%22Statistics%22">Statistics</searchLink><br /><searchLink fieldCode="DE" term="%22Vocal+cords%22">Vocal cords</searchLink>
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  Label: Abstract
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  Data: Purpose: Therapies for certain voice disorders purport principles of skeletal muscle rehabilitation to increase muscle mass, strength, and endurance. However, applicability of limb muscle rehabilitation to the laryngeal muscles has not been tested. In this study, the authors examined the feasibility of the rat thyroarytenoid muscle to remodel as a consequence of increased activity instantiated through chronic electrical stimulation. Method: Twenty adult Sprague-Dawley rats (Rattus norvegicus), assigned to a 1-week or 2-week stimulation group, were implanted with a nerve cuff electrode placed around the right recurrent laryngeal nerve and were fitted with a head connector. All animals were placed under anesthesia twice a day for 1 hr each time. Following the training, rats were killed, and thyroarytenoid muscles were isolated for histology and immunohistochemistry. Results: Mean muscle fiber area decreased, neuromuscular junction density increased, mitochondrial content increased qualitatively, and glycogen-positive fibers increased, demonstrating exercise-induced changes similar to those seen in limb muscles after endurance training. Conclusion: Rat thyroarytenoid muscles are capable of remodeling in response to chronic electrical stimulation. [ABSTRACT FROM AUTHOR]
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  Group: Ab
  Data: <i>Copyright of Journal of Speech, Language & Hearing Research is the property of American Speech-Language-Hearing Association and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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        Value: 10.1044/1092-4388(2010/10-0127)
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        Text: English
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      Pagination:
        PageCount: 9
        StartPage: 845
    Subjects:
      – SubjectFull: Statistical correlation
        Type: general
      – SubjectFull: Data analysis
        Type: general
      – SubjectFull: Voice disorder treatment
        Type: general
      – SubjectFull: Analysis of variance
        Type: general
      – SubjectFull: Animal experimentation
        Type: general
      – SubjectFull: Biological models
        Type: general
      – SubjectFull: Electric stimulation
        Type: general
      – SubjectFull: Immunohistochemistry
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      – SubjectFull: Rats
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      – SubjectFull: Research funding
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      – SubjectFull: Statistics
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      – SubjectFull: Vocal cords
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    Titles:
      – TitleFull: Chronic Stimulation-Induced Changes in the Rodent Thyroarytenoid Muscle.
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              Text: Jun2011
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              Y: 2011
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