Genome-Wide Association Study of Receptive Language Ability of 12-Year-Olds.

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Bibliographic Details
Title:	Genome-Wide Association Study of Receptive Language Ability of 12-Year-Olds.
Authors:	Harlaar, Nicole¹ nicole.harlaar@colorado.edu, Meaburn, Emma L.² e.meaburn@bbk.ac.uk, Hayiou-Thomas, Marianna E.³, Davis, Oliver S. P.⁴, Docherty, Sophia⁵, Hanscombe, Ken B.⁵, Haworth, Claire M. A.⁵, Price, Thomas S.⁶, Trzaskowski, Maciej⁵, Dale, Philip S.⁷, Plomin, Robert⁵
Source:	Journal of Speech, Language & Hearing Research. Feb2014, Vol. 57 Issue 1, p96-105. 10p. 5 Graphs.
Subject Terms:	Language disorders, Comparative grammar, Language acquisition, Speech evaluation, Vocabulary, Children, Language disorder diagnosis, Genetic polymorphisms, Genomes, Semantics, Genetics
Abstract:	Purpose: Researchers have previously shown that individual differences in measures of receptive language ability at age 12 are highly heritable. In the current study, the authors attempted to identify some of the genes responsible for the heritability of receptive language ability using a genome-wide association approach. Method: The authors administered 4 Internet-based measures of receptive language (vocabulary, semantics, syntax, and pragmatics) to a sample of 2,329 twelve-year-olds for whom DNA and genome-wide genotyping were available. Nearly 700,000 single-nucleotide polymorphisms (SNPs) and 1 million imputed SNPs were included in a genome-wide association analysis of receptive language composite scores. Results: No SNP associations met the demanding criterion of genome-wide significance that corrects for multiple testing across the genome (p < 5 × 10-8). The strongest SNP association did not replicate in an additional sample of 2,639 twelve-year-olds. Conclusions: These results indicate that individual differences in receptive language ability in the general population do not reflect common genetic variants that account for more than 3% of the phenotypic variance. The search for genetic variants associated with language skill will require larger samples and additional methods to identify and functionally characterize the full spectrum of risk variants. [ABSTRACT FROM AUTHOR]
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Database:	Education Research Complete

Description
Abstract:	Purpose: Researchers have previously shown that individual differences in measures of receptive language ability at age 12 are highly heritable. In the current study, the authors attempted to identify some of the genes responsible for the heritability of receptive language ability using a genome-wide association approach. Method: The authors administered 4 Internet-based measures of receptive language (vocabulary, semantics, syntax, and pragmatics) to a sample of 2,329 twelve-year-olds for whom DNA and genome-wide genotyping were available. Nearly 700,000 single-nucleotide polymorphisms (SNPs) and 1 million imputed SNPs were included in a genome-wide association analysis of receptive language composite scores. Results: No SNP associations met the demanding criterion of genome-wide significance that corrects for multiple testing across the genome (p < 5 × 10-8). The strongest SNP association did not replicate in an additional sample of 2,639 twelve-year-olds. Conclusions: These results indicate that individual differences in receptive language ability in the general population do not reflect common genetic variants that account for more than 3% of the phenotypic variance. The search for genetic variants associated with language skill will require larger samples and additional methods to identify and functionally characterize the full spectrum of risk variants. [ABSTRACT FROM AUTHOR]
ISSN:	10924388
DOI:	10.1044/1092-4388(2013/12-0303)