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Mechanistic safety assessment via multi-omic characterisation of systemic pathway perturbations following in vivo MAT2A inhibition.

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Title: Mechanistic safety assessment via multi-omic characterisation of systemic pathway perturbations following in vivo MAT2A inhibition.
Authors: Fogal, Valentina1,2 (AUTHOR), Michopoulos, Filippos3 (AUTHOR), Jarnuczak, Andrew F.4 (AUTHOR), Hamza, Ghaith M.5 (AUTHOR), Harlfinger, Stephanie6 (AUTHOR), Davey, Paul7 (AUTHOR), Hulme, Heather8 (AUTHOR), Atkinson, Stephen J.7 (AUTHOR), Gabrowski, Piotr9 (AUTHOR), Cheung, Tony10 (AUTHOR), Grondine, Michael10 (AUTHOR), Hoover, Clare11 (AUTHOR), Rose, Jonathan12 (AUTHOR), Bray, Chandler2 (AUTHOR), Foster, Alison J.13 (AUTHOR), Askin, Sean14 (AUTHOR), Majumder, Muntasir Mamun15 (AUTHOR), Fitzpatrick, Paul15 (AUTHOR), Miele, Eric5 (AUTHOR), Macdonald, Ruth12 (AUTHOR)
Source: Archives of Toxicology. Aug2024, Vol. 98 Issue 8, p2589-2603. 15p.
Database: Environment Complete
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ISSN:03405761
DOI:10.1007/s00204-024-03771-w