Prolonged low-dose neutron irradiation induces late cellular and molecular impairments in the mice hippocampus and causes cognitive deficit.
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| Title: | Prolonged low-dose neutron irradiation induces late cellular and molecular impairments in the mice hippocampus and causes cognitive deficit. |
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| Authors: | Rodina, Alla V.1 (AUTHOR) Rodina_AV@nrcki.ru, Zhirnik, A. S.1 (AUTHOR), Vysotskaya, O. V.1 (AUTHOR), Smirnova, O. D.1 (AUTHOR), Cheshigin, I. V.1 (AUTHOR), Moskaleva, E. Yu.1 (AUTHOR) |
| Source: | Radiation & Environmental Biophysics. Mar2026, Vol. 65 Issue 1, p197-209. 13p. |
| Subject Terms: | *Neutron irradiation, *Neuroinflammation, *Cognition disorders, *Astrocytes, *Hippocampus (Brain), *Microglia, *Spatial memory, *Progenitor cells |
| Abstract: | Late effects of prolonged low-dose neutron exposure on the brain function remain poorly studied. We analyzed the content of neural progenitor cells, microglia and astrocytes, the number of PSD-95 puncta, the expression level of pro- and anti-inflammatory cytokines in the hippocampus, and long-term spatial and recognition memory in conventional (CV) and specific pathogen-free (SPF) mice 2 months after prolonged neutron irradiation at doses of 0.05 (1 day) and 0.5 Gy (10 day). Neurogenesis was intact in all mice. The level of PSD-95 was increased only in CV mice irradiated at 0.05 Gy. In CV mice, an increase in the number of microglia was recorded at both doses and astrocytes at 0.05 Gy; in SPF mice, both microglia and astrocytes increased only after irradiation at 0.5 Gy. The expression of TNFα and IL-1β increased in all irradiated mice; the expression of TGFβ decreased in CV mice irradiated at 0.5 Gy. These findings suggest that the severity of neuroinflammation in irradiated CV mice was higher than in SPF mice. Conventional analysis of escape latencies in the Morris water maze (MWM) revealed an intact spatial memory in both groups, while analysis of the swimming strategies demonstrated spatial reference memory deficits in CV mice irradiated at 0.05 Gy and in SPF mice irradiated at 0.5 Gy. Novel object recognition (NOR) assay demonstrated decreased recognition index only in CV mice (both doses). Thus, the housing conditions of animal before expose affect the neuroinflammation level and cognitive impairment late after prolonged low-dose neutron irradiation. [ABSTRACT FROM AUTHOR] |
| Database: | Energy & Power Source |
| FullText | Text: Availability: 0 |
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| Header | DbId: enr DbLabel: Energy & Power Source An: 193393855 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Prolonged low-dose neutron irradiation induces late cellular and molecular impairments in the mice hippocampus and causes cognitive deficit. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Rodina%2C+Alla+V%2E%22">Rodina, Alla V.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<i> Rodina_AV@nrcki.ru</i><br /><searchLink fieldCode="AR" term="%22Zhirnik%2C+A%2E+S%2E%22">Zhirnik, A. S.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Vysotskaya%2C+O%2E+V%2E%22">Vysotskaya, O. V.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Smirnova%2C+O%2E+D%2E%22">Smirnova, O. D.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Cheshigin%2C+I%2E+V%2E%22">Cheshigin, I. V.</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Moskaleva%2C+E%2E+Yu%2E%22">Moskaleva, E. Yu.</searchLink><relatesTo>1</relatesTo> (AUTHOR) – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Radiation+%26+Environmental+Biophysics%22">Radiation & Environmental Biophysics</searchLink>. Mar2026, Vol. 65 Issue 1, p197-209. 13p. – Name: Subject Label: Subject Terms Group: Su Data: *<searchLink fieldCode="DE" term="%22Neutron+irradiation%22">Neutron irradiation</searchLink><br />*<searchLink fieldCode="DE" term="%22Neuroinflammation%22">Neuroinflammation</searchLink><br />*<searchLink fieldCode="DE" term="%22Cognition+disorders%22">Cognition disorders</searchLink><br />*<searchLink fieldCode="DE" term="%22Astrocytes%22">Astrocytes</searchLink><br />*<searchLink fieldCode="DE" term="%22Hippocampus+%28Brain%29%22">Hippocampus (Brain)</searchLink><br />*<searchLink fieldCode="DE" term="%22Microglia%22">Microglia</searchLink><br />*<searchLink fieldCode="DE" term="%22Spatial+memory%22">Spatial memory</searchLink><br />*<searchLink fieldCode="DE" term="%22Progenitor+cells%22">Progenitor cells</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Late effects of prolonged low-dose neutron exposure on the brain function remain poorly studied. We analyzed the content of neural progenitor cells, microglia and astrocytes, the number of PSD-95 puncta, the expression level of pro- and anti-inflammatory cytokines in the hippocampus, and long-term spatial and recognition memory in conventional (CV) and specific pathogen-free (SPF) mice 2 months after prolonged neutron irradiation at doses of 0.05 (1 day) and 0.5 Gy (10 day). Neurogenesis was intact in all mice. The level of PSD-95 was increased only in CV mice irradiated at 0.05 Gy. In CV mice, an increase in the number of microglia was recorded at both doses and astrocytes at 0.05 Gy; in SPF mice, both microglia and astrocytes increased only after irradiation at 0.5 Gy. The expression of TNFα and IL-1β increased in all irradiated mice; the expression of TGFβ decreased in CV mice irradiated at 0.5 Gy. These findings suggest that the severity of neuroinflammation in irradiated CV mice was higher than in SPF mice. Conventional analysis of escape latencies in the Morris water maze (MWM) revealed an intact spatial memory in both groups, while analysis of the swimming strategies demonstrated spatial reference memory deficits in CV mice irradiated at 0.05 Gy and in SPF mice irradiated at 0.5 Gy. Novel object recognition (NOR) assay demonstrated decreased recognition index only in CV mice (both doses). Thus, the housing conditions of animal before expose affect the neuroinflammation level and cognitive impairment late after prolonged low-dose neutron irradiation. [ABSTRACT FROM AUTHOR] |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1007/s00411-026-01208-9 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 13 StartPage: 197 Subjects: – SubjectFull: Neutron irradiation Type: general – SubjectFull: Neuroinflammation Type: general – SubjectFull: Cognition disorders Type: general – SubjectFull: Astrocytes Type: general – SubjectFull: Hippocampus (Brain) Type: general – SubjectFull: Microglia Type: general – SubjectFull: Spatial memory Type: general – SubjectFull: Progenitor cells Type: general Titles: – TitleFull: Prolonged low-dose neutron irradiation induces late cellular and molecular impairments in the mice hippocampus and causes cognitive deficit. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Rodina, Alla V. – PersonEntity: Name: NameFull: Zhirnik, A. S. – PersonEntity: Name: NameFull: Vysotskaya, O. V. – PersonEntity: Name: NameFull: Smirnova, O. D. – PersonEntity: Name: NameFull: Cheshigin, I. V. – PersonEntity: Name: NameFull: Moskaleva, E. Yu. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: Mar2026 Type: published Y: 2026 Identifiers: – Type: issn-print Value: 0301634X Numbering: – Type: volume Value: 65 – Type: issue Value: 1 Titles: – TitleFull: Radiation & Environmental Biophysics Type: main |
| ResultId | 1 |
