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Bone Density in Adolescents and Young Adults with Autism Spectrum Disorders

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Title: Bone Density in Adolescents and Young Adults with Autism Spectrum Disorders
Language: English
Authors: Ekhlaspour, Laya, Baskaran, Charumathi, Campoverde, Karen Joanie, Sokoloff, Natalia Cano, Neumeyer, Ann M., Misra, Madhusmita
Source: Journal of Autism and Developmental Disorders. Nov 2016 46(11):3387-3391.
Availability: Springer. 233 Spring Street, New York, NY 10013. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-348-4505; e-mail: service-ny@springer.com; Web site: http://www.springerlink.com
Peer Reviewed: Y
Page Count: 5
Publication Date: 2016
Document Type: Journal Articles
Reports - Research
Descriptors: Autism, Pervasive Developmental Disorders, Human Body, At Risk Persons, Late Adolescents, Young Adults, Comparative Analysis, Radiology, Physiology
DOI: 10.1007/s10803-016-2871-9
ISSN: 0162-3257
Abstract: Patients with autism spectrum disorder (ASD) are at increased risk for fracture, and peri-pubertal boys with ASD have lower bone mineral density (BMD) than controls. Data are lacking regarding BMD in older adolescents with ASD. We compared BMD using dual-energy X-ray absorptiometry in 9 adolescents/young adults with ASD against 9 typically developing matched controls. Patients with ASD and controls were excluded if they had other underlying conditions that may affect bone. Compared to controls, patients with ASD had (i) lower femoral neck and hip BMD Z-scores, and (ii) lower spine, femoral neck and hip height adjusted BMD Z-scores even after controlling for BMI. Understanding the underlying pathophysiology will be key to developing therapies to improve BMD and reduce fracture risk.
Abstractor: As Provided
Number of References: 31
Entry Date: 2016
Accession Number: EJ1117516
Database: ERIC
FullText Links:
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  Data: Bone Density in Adolescents and Young Adults with Autism Spectrum Disorders
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  Data: <searchLink fieldCode="AR" term="%22Ekhlaspour%2C+Laya%22">Ekhlaspour, Laya</searchLink><br /><searchLink fieldCode="AR" term="%22Baskaran%2C+Charumathi%22">Baskaran, Charumathi</searchLink><br /><searchLink fieldCode="AR" term="%22Campoverde%2C+Karen+Joanie%22">Campoverde, Karen Joanie</searchLink><br /><searchLink fieldCode="AR" term="%22Sokoloff%2C+Natalia+Cano%22">Sokoloff, Natalia Cano</searchLink><br /><searchLink fieldCode="AR" term="%22Neumeyer%2C+Ann+M%2E%22">Neumeyer, Ann M.</searchLink><br /><searchLink fieldCode="AR" term="%22Misra%2C+Madhusmita%22">Misra, Madhusmita</searchLink>
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  Data: <searchLink fieldCode="SO" term="%22Journal+of+Autism+and+Developmental+Disorders%22"><i>Journal of Autism and Developmental Disorders</i></searchLink>. Nov 2016 46(11):3387-3391.
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  Data: Springer. 233 Spring Street, New York, NY 10013. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-348-4505; e-mail: service-ny@springer.com; Web site: http://www.springerlink.com
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  Data: Patients with autism spectrum disorder (ASD) are at increased risk for fracture, and peri-pubertal boys with ASD have lower bone mineral density (BMD) than controls. Data are lacking regarding BMD in older adolescents with ASD. We compared BMD using dual-energy X-ray absorptiometry in 9 adolescents/young adults with ASD against 9 typically developing matched controls. Patients with ASD and controls were excluded if they had other underlying conditions that may affect bone. Compared to controls, patients with ASD had (i) lower femoral neck and hip BMD Z-scores, and (ii) lower spine, femoral neck and hip height adjusted BMD Z-scores even after controlling for BMI. Understanding the underlying pathophysiology will be key to developing therapies to improve BMD and reduce fracture risk.
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      – SubjectFull: Late Adolescents
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      – TitleFull: Bone Density in Adolescents and Young Adults with Autism Spectrum Disorders
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