Pattern Separation and Goal-Directed Behavior in the Aged Canine
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| Title: | Pattern Separation and Goal-Directed Behavior in the Aged Canine |
|---|---|
| Language: | English |
| Authors: | Snigdha, Shikha, Yassa, Michael A., deRivera, Christina, Milgram, Norton W., Cotman, Carl W. |
| Source: | Learning & Memory. Mar 2017 24(3):123-131. |
| Availability: | Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org |
| Peer Reviewed: | Y |
| Page Count: | 9 |
| Publication Date: | 2017 |
| Document Type: | Journal Articles Reports - Research |
| Descriptors: | Animals, Cognitive Processes, Pattern Recognition, Task Analysis, Age, Inhibition, Spatial Ability, Memory, Brain |
| DOI: | 10.1101/lm.043422.116 |
| ISSN: | 1072-0502 |
| Abstract: | The pattern separation task has recently emerged as a behavioral model of hippocampus function and has been used in several pharmaceutical trials. The canine is a useful model to evaluate a multitude of hippocampal-dependent cognitive tasks that parallel those in humans. Thus, this study was designed to evaluate the suitability of pattern separation task(s) for detecting age-related changes in canines. We also assessed the dogs' ability to show pattern separation and discrimination reversal, which provides a novel extension of the pattern separation learning literature. Our data show that aged dogs are impaired on a complex pattern separation task (six-well task) relative to easier tasks (four-well or six-well pattern discrimination task), and that the age-related deficits are due to loss of perceptual and inhibitory control in addition to the loss of spatial discrimination and pattern separation ability. Our data also suggest that aged animals show pattern separation deficits when the objects are brought progressively closer together while changing the location of both correct and incorrect objects. However, if the location of any one object is fixed the animals tend to use alternate strategies. Overall, these data provide important insight into age-related pattern separation deficits in a higher animal model and offers additional means for evaluating the impact of lifestyle and pharmaceutical interventions on episodic memory in preclinical trials. |
| Abstractor: | As Provided |
| Entry Date: | 2017 |
| Accession Number: | EJ1131269 |
| Database: | ERIC |
| FullText | Text: Availability: 0 |
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| Header | DbId: eric DbLabel: ERIC An: EJ1131269 AccessLevel: 3 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Pattern Separation and Goal-Directed Behavior in the Aged Canine – Name: Language Label: Language Group: Lang Data: English – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Snigdha%2C+Shikha%22">Snigdha, Shikha</searchLink><br /><searchLink fieldCode="AR" term="%22Yassa%2C+Michael+A%2E%22">Yassa, Michael A.</searchLink><br /><searchLink fieldCode="AR" term="%22deRivera%2C+Christina%22">deRivera, Christina</searchLink><br /><searchLink fieldCode="AR" term="%22Milgram%2C+Norton+W%2E%22">Milgram, Norton W.</searchLink><br /><searchLink fieldCode="AR" term="%22Cotman%2C+Carl+W%2E%22">Cotman, Carl W.</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="SO" term="%22Learning+%26+Memory%22"><i>Learning & Memory</i></searchLink>. Mar 2017 24(3):123-131. – Name: Avail Label: Availability Group: Avail Data: Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org – Name: PeerReviewed Label: Peer Reviewed Group: SrcInfo Data: Y – Name: Pages Label: Page Count Group: Src Data: 9 – Name: DatePubCY Label: Publication Date Group: Date Data: 2017 – Name: TypeDocument Label: Document Type Group: TypDoc Data: Journal Articles<br />Reports - Research – Name: Subject Label: Descriptors Group: Su Data: <searchLink fieldCode="DE" term="%22Animals%22">Animals</searchLink><br /><searchLink fieldCode="DE" term="%22Cognitive+Processes%22">Cognitive Processes</searchLink><br /><searchLink fieldCode="DE" term="%22Pattern+Recognition%22">Pattern Recognition</searchLink><br /><searchLink fieldCode="DE" term="%22Task+Analysis%22">Task Analysis</searchLink><br /><searchLink fieldCode="DE" term="%22Age%22">Age</searchLink><br /><searchLink fieldCode="DE" term="%22Inhibition%22">Inhibition</searchLink><br /><searchLink fieldCode="DE" term="%22Spatial+Ability%22">Spatial Ability</searchLink><br /><searchLink fieldCode="DE" term="%22Memory%22">Memory</searchLink><br /><searchLink fieldCode="DE" term="%22Brain%22">Brain</searchLink> – Name: DOI Label: DOI Group: ID Data: 10.1101/lm.043422.116 – Name: ISSN Label: ISSN Group: ISSN Data: 1072-0502 – Name: Abstract Label: Abstract Group: Ab Data: The pattern separation task has recently emerged as a behavioral model of hippocampus function and has been used in several pharmaceutical trials. The canine is a useful model to evaluate a multitude of hippocampal-dependent cognitive tasks that parallel those in humans. Thus, this study was designed to evaluate the suitability of pattern separation task(s) for detecting age-related changes in canines. We also assessed the dogs' ability to show pattern separation and discrimination reversal, which provides a novel extension of the pattern separation learning literature. Our data show that aged dogs are impaired on a complex pattern separation task (six-well task) relative to easier tasks (four-well or six-well pattern discrimination task), and that the age-related deficits are due to loss of perceptual and inhibitory control in addition to the loss of spatial discrimination and pattern separation ability. Our data also suggest that aged animals show pattern separation deficits when the objects are brought progressively closer together while changing the location of both correct and incorrect objects. However, if the location of any one object is fixed the animals tend to use alternate strategies. Overall, these data provide important insight into age-related pattern separation deficits in a higher animal model and offers additional means for evaluating the impact of lifestyle and pharmaceutical interventions on episodic memory in preclinical trials. – Name: AbstractInfo Label: Abstractor Group: Ab Data: As Provided – Name: DateEntry Label: Entry Date Group: Date Data: 2017 – Name: AN Label: Accession Number Group: ID Data: EJ1131269 |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=eric&AN=EJ1131269 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1101/lm.043422.116 Languages: – Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 123 Subjects: – SubjectFull: Animals Type: general – SubjectFull: Cognitive Processes Type: general – SubjectFull: Pattern Recognition Type: general – SubjectFull: Task Analysis Type: general – SubjectFull: Age Type: general – SubjectFull: Inhibition Type: general – SubjectFull: Spatial Ability Type: general – SubjectFull: Memory Type: general – SubjectFull: Brain Type: general Titles: – TitleFull: Pattern Separation and Goal-Directed Behavior in the Aged Canine Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Snigdha, Shikha – PersonEntity: Name: NameFull: Yassa, Michael A. – PersonEntity: Name: NameFull: deRivera, Christina – PersonEntity: Name: NameFull: Milgram, Norton W. – PersonEntity: Name: NameFull: Cotman, Carl W. IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Type: published Y: 2017 Identifiers: – Type: issn-print Value: 1072-0502 Numbering: – Type: volume Value: 24 – Type: issue Value: 3 Titles: – TitleFull: Learning & Memory Type: main |
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