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Long-Term Averaged Spectrum Descriptors of Dysarthria in Patients with Parkinson's Disease Treated with Subthalamic Nucleus Deep Brain Stimulation

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Title: Long-Term Averaged Spectrum Descriptors of Dysarthria in Patients with Parkinson's Disease Treated with Subthalamic Nucleus Deep Brain Stimulation
Language: English
Authors: Svihlik, Jan, Novotny, Michal, Tykalova, Tereza, Polakova, Kamila, Brozova, Hana, Kryze, Petr, Sousa, Mario, Krack, Paul, Tripoliti, Elina, Ruzicka, Evzen, Jech, Robert, Rusz, Jan (ORCID 0000-0002-1036-3054)
Source: Journal of Speech, Language, and Hearing Research. Dec 2022 65(12):4690-4699.
Availability: American Speech-Language-Hearing Association. 2200 Research Blvd #250, Rockville, MD 20850. Tel: 301-296-5700; Fax: 301-296-8580; e-mail: slhr@asha.org; Web site: http://jslhr.pubs.asha.org
Peer Reviewed: Y
Page Count: 10
Publication Date: 2022
Document Type: Journal Articles
Reports - Research
Descriptors: Neurological Impairments, Articulation Impairments, Symptoms (Individual Disorders), Stimulation, Brain, Speech Communication, Speech Impairments, Severity (of Disability), Therapy, Adults, Program Effectiveness
DOI: 10.1044/2022_JSLHR-22-00308
ISSN: 1092-4388
1558-9102
Abstract: Purpose: This study aimed to evaluate whether long-term averaged spectrum (LTAS) descriptors for reading and monologue are suitable to detect worsening of dysarthria in patients with Parkinson's disease (PD) treated with subthalamic nucleus deep brain stimulation (STN-DBS) with potential effect of ON and OFF stimulation conditions and types of connected speech. Method: Four spectral moments based on LTAS were computed for monologue and reading passage collected from 23 individuals with PD treated with bilateral STN-DBS and 23 age- and gender-matched healthy controls. Speech performance of patients with PD was compared in ON and OFF STN-DBS conditions. Results: All LTAS spectral moments including mean, standard deviation, skewness, and kurtosis across both monologue and reading passage were able to significantly distinguish between patients with PD in both stimulation conditions and control speakers. The spectral mean was the only LTAS measure sensitive to capture better speech performance in STN-DBS ON, as compared to the STN-DBS OFF stimulation condition (p < 0.05). Standardized reading passage was more sensitive compared to monologue in detecting dysarthria severity via LTAS descriptors with an area under the curve of up to 0.92 obtained between PD and control groups. Conclusions: Our findings confirmed that LTAS is a suitable approach to objectively describe changes in speech impairment severity due to STN-DBS therapy in patients with PD. We envisage these results as an important step toward a continuum development of technological solutions for the automated assessment of stimulation-induced dysarthria.
Abstractor: As Provided
Entry Date: 2023
Accession Number: EJ1375744
Database: ERIC
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  Data: Long-Term Averaged Spectrum Descriptors of Dysarthria in Patients with Parkinson&#39;s Disease Treated with Subthalamic Nucleus Deep Brain Stimulation
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  Data: American Speech-Language-Hearing Association. 2200 Research Blvd #250, Rockville, MD 20850. Tel: 301-296-5700; Fax: 301-296-8580; e-mail: slhr@asha.org; Web site: http://jslhr.pubs.asha.org
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– Name: Abstract
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  Data: Purpose: This study aimed to evaluate whether long-term averaged spectrum (LTAS) descriptors for reading and monologue are suitable to detect worsening of dysarthria in patients with Parkinson&#39;s disease (PD) treated with subthalamic nucleus deep brain stimulation (STN-DBS) with potential effect of ON and OFF stimulation conditions and types of connected speech. Method: Four spectral moments based on LTAS were computed for monologue and reading passage collected from 23 individuals with PD treated with bilateral STN-DBS and 23 age- and gender-matched healthy controls. Speech performance of patients with PD was compared in ON and OFF STN-DBS conditions. Results: All LTAS spectral moments including mean, standard deviation, skewness, and kurtosis across both monologue and reading passage were able to significantly distinguish between patients with PD in both stimulation conditions and control speakers. The spectral mean was the only LTAS measure sensitive to capture better speech performance in STN-DBS ON, as compared to the STN-DBS OFF stimulation condition (p &lt; 0.05). Standardized reading passage was more sensitive compared to monologue in detecting dysarthria severity via LTAS descriptors with an area under the curve of up to 0.92 obtained between PD and control groups. Conclusions: Our findings confirmed that LTAS is a suitable approach to objectively describe changes in speech impairment severity due to STN-DBS therapy in patients with PD. We envisage these results as an important step toward a continuum development of technological solutions for the automated assessment of stimulation-induced dysarthria.
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