'Neural Noise' in Auditory Responses in Young Autistic and Neurotypical Children
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| Title: | 'Neural Noise' in Auditory Responses in Young Autistic and Neurotypical Children |
|---|---|
| Language: | English |
| Authors: | Patrick Dwyer (ORCID |
| Source: | Journal of Autism and Developmental Disorders. 2024 54(2):642-661. |
| Availability: | Springer. Available from: Springer Nature. One New York Plaza, Suite 4600, New York, NY 10004. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-460-1700; e-mail: customerservice@springernature.com; Web site: https://link.springer.com/ |
| Peer Reviewed: | Y |
| Page Count: | 20 |
| Publication Date: | 2024 |
| Sponsoring Agency: | National Institutes of Health (NIH) (DHHS) National Institute on Deafness and Other Communication Disorders (NIDCD) (DHHS/NIH) National Institute of General Medical Sciences (NIGMS) (DHHS/NIH) Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (DHHS/NIH) |
| Contract Number: | 1RO1MH089626 F30DC019510 T32GM007347 P50HD093079 |
| Document Type: | Journal Articles Reports - Research |
| Descriptors: | Acoustics, Auditory Perception, Young Children, Autism Spectrum Disorders, Sensory Experience, Physiology, Responses |
| DOI: | 10.1007/s10803-022-05797-4 |
| ISSN: | 0162-3257 1573-3432 |
| Abstract: | Elevated "neural noise" has been advanced as an explanation of autism and autistic sensory experiences. However, functional neuroimaging measures of neural noise may be vulnerable to contamination by recording noise. This study explored variability of electrophysiological responses to tones of different intensities in 127 autistic and 79 typically-developing children aged 2-5 years old. A rigorous data processing pipeline, including advanced visualizations of different signal sources that were maximally independent across different time lags, was used to identify and eliminate putative recording noise. Inter-trial variability was measured using median absolute deviations (MADs) of EEG amplitudes across trials and inter-trial phase coherence (ITPC). ITPC was elevated in autism in the 50 and 60 dB intensity conditions, suggesting diminished (rather than elevated) neural noise in autism, although reduced ITPC to soft 50 dB sounds was associated with increased loudness discomfort. Autistic and non-autistic participants did not differ in MADs, and indeed, the vast majority of the statistical tests examined in this study yielded no significant effects. These results appear inconsistent with the neural noise account. |
| Abstractor: | As Provided |
| Entry Date: | 2024 |
| Accession Number: | EJ1409608 |
| Database: | ERIC |
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| Abstract: | Elevated "neural noise" has been advanced as an explanation of autism and autistic sensory experiences. However, functional neuroimaging measures of neural noise may be vulnerable to contamination by recording noise. This study explored variability of electrophysiological responses to tones of different intensities in 127 autistic and 79 typically-developing children aged 2-5 years old. A rigorous data processing pipeline, including advanced visualizations of different signal sources that were maximally independent across different time lags, was used to identify and eliminate putative recording noise. Inter-trial variability was measured using median absolute deviations (MADs) of EEG amplitudes across trials and inter-trial phase coherence (ITPC). ITPC was elevated in autism in the 50 and 60 dB intensity conditions, suggesting diminished (rather than elevated) neural noise in autism, although reduced ITPC to soft 50 dB sounds was associated with increased loudness discomfort. Autistic and non-autistic participants did not differ in MADs, and indeed, the vast majority of the statistical tests examined in this study yielded no significant effects. These results appear inconsistent with the neural noise account. |
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| ISSN: | 0162-3257 1573-3432 |
| DOI: | 10.1007/s10803-022-05797-4 |
