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Ultrasensitive Detection of Gallic Acid via Synergistic Enhancement of Single-Walled Carbon Nanotubes@Zeolitic Imidazolate Framework-8: Comprehensive Innovative Experiment for Undergraduates

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Title: Ultrasensitive Detection of Gallic Acid via Synergistic Enhancement of Single-Walled Carbon Nanotubes@Zeolitic Imidazolate Framework-8: Comprehensive Innovative Experiment for Undergraduates
Language: English
Authors: Hongyuan Zhao (ORCID 0000-0003-3944-6854), Mengyuan Zhao, Jing Tang, Zhongming Song (ORCID 0000-0001-6878-5818), Zirong Li
Source: Journal of Chemical Education. 2026 103(1):595-602.
Availability: Division of Chemical Education, Inc. and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc
Peer Reviewed: Y
Page Count: 8
Publication Date: 2026
Document Type: Journal Articles
Reports - Evaluative
Education Level: Higher Education
Postsecondary Education
Descriptors: Undergraduate Students, College Science, Chemistry, Science Experiments, Scientific Concepts, Laboratory Equipment, Laboratory Training, Measurement Equipment, Learning Objectives, Science Process Skills, Scientific Literacy
DOI: 10.1021/acs.jchemed.5c01516
ISSN: 0021-9584
1938-1328
Abstract: Gallic acid (GA) with strong antioxidant and antibacterial properties has been widely used in the food and pharmaceutical industries. However, excessive GA may induce gastrointestinal irritation and impose metabolic burdens on the liver and kidneys. Herein, we developed a novel electrochemical sensor based on the single-walled carbon nanotubes@zeolitic imidazolate framework-8 decorated electrode (SCT@ZMF/GCE) for the ultrasensitive detection of GA. SCT with a hollow nanotube structure provided excellent conductivity properties because of the interconnected conductive carbon networks, and ZMF nanoparticles with high porosity exhibited strong adsorption capacity for GA molecules. SCT@ZMF/GCE displayed exceptional GA detection (Linear detection range: 0.1-30 [micrometer]; limit of detection: 7.84 [nanometer]). This comprehensive innovative experiment was designed for senior undergraduate students majoring in materials science, chemistry, and other related fields. This experiment contains a literature review, nanocomposite preparation, material characterization, electrochemical detection, and data processing. Integrating this experiment into undergraduate teaching will help participants achieve the following objectives: (1) understanding the importance of GA concentration for human health; (2) designing a simple, low-cost, and innovative GA analysis method; (3) optimizing the electrochemical detection condition; and (4) mastering the GA detection mechanism and strengthening the experimental skills and scientific literacy.
Abstractor: As Provided
Entry Date: 2026
Accession Number: EJ1493843
Database: ERIC
FullText Text:
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  Data: Ultrasensitive Detection of Gallic Acid via Synergistic Enhancement of Single-Walled Carbon Nanotubes@Zeolitic Imidazolate Framework-8: Comprehensive Innovative Experiment for Undergraduates
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  Data: <searchLink fieldCode="AR" term="%22Hongyuan+Zhao%22">Hongyuan Zhao</searchLink> (ORCID <externalLink term="https://orcid.org/0000-0003-3944-6854">0000-0003-3944-6854</externalLink>)<br /><searchLink fieldCode="AR" term="%22Mengyuan+Zhao%22">Mengyuan Zhao</searchLink><br /><searchLink fieldCode="AR" term="%22Jing+Tang%22">Jing Tang</searchLink><br /><searchLink fieldCode="AR" term="%22Zhongming+Song%22">Zhongming Song</searchLink> (ORCID <externalLink term="https://orcid.org/0000-0001-6878-5818">0000-0001-6878-5818</externalLink>)<br /><searchLink fieldCode="AR" term="%22Zirong+Li%22">Zirong Li</searchLink>
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  Data: <searchLink fieldCode="SO" term="%22Journal+of+Chemical+Education%22"><i>Journal of Chemical Education</i></searchLink>. 2026 103(1):595-602.
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  Data: Division of Chemical Education, Inc. and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc
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  Data: 8
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  Data: 10.1021/acs.jchemed.5c01516
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  Data: 0021-9584<br />1938-1328
– Name: Abstract
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  Data: Gallic acid (GA) with strong antioxidant and antibacterial properties has been widely used in the food and pharmaceutical industries. However, excessive GA may induce gastrointestinal irritation and impose metabolic burdens on the liver and kidneys. Herein, we developed a novel electrochemical sensor based on the single-walled carbon nanotubes@zeolitic imidazolate framework-8 decorated electrode (SCT@ZMF/GCE) for the ultrasensitive detection of GA. SCT with a hollow nanotube structure provided excellent conductivity properties because of the interconnected conductive carbon networks, and ZMF nanoparticles with high porosity exhibited strong adsorption capacity for GA molecules. SCT@ZMF/GCE displayed exceptional GA detection (Linear detection range: 0.1-30 [micrometer]; limit of detection: 7.84 [nanometer]). This comprehensive innovative experiment was designed for senior undergraduate students majoring in materials science, chemistry, and other related fields. This experiment contains a literature review, nanocomposite preparation, material characterization, electrochemical detection, and data processing. Integrating this experiment into undergraduate teaching will help participants achieve the following objectives: (1) understanding the importance of GA concentration for human health; (2) designing a simple, low-cost, and innovative GA analysis method; (3) optimizing the electrochemical detection condition; and (4) mastering the GA detection mechanism and strengthening the experimental skills and scientific literacy.
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