View in EDS

Chimera X Interface to Enhance Understanding in Biochemistry and Immunology

Saved in:
Bibliographic Details
Title: Chimera X Interface to Enhance Understanding in Biochemistry and Immunology
Language: English
Authors: Dalpiaz Giovana (ORCID 0000-0003-0281-3171), Krohn Muriel Schiling (ORCID 0009-0000-2077-3615), Groehs Eduarda (ORCID 0009-0001-7140-8519), Anjos André da Silva (ORCID 0000-0003-3714-3171), Meireles R. Mariana (ORCID 0000-0002-2024-2846)
Source: Biochemistry and Molecular Biology Education. 2026 54(1):92-102.
Availability: Wiley. Available from: John Wiley & Sons, Inc. 111 River Street, Hoboken, NJ 07030. Tel: 800-835-6770; e-mail: cs-journals@wiley.com; Web site: https://www.wiley.com/en-us
Peer Reviewed: Y
Page Count: 11
Publication Date: 2026
Document Type: Journal Articles
Reports - Research
Descriptors: Biochemistry, Scientific Concepts, Molecular Structure, Tutorial Programs, Science Instruction, Teaching Methods, Visualization, Computer Software, Computer Simulation, Genetics, Immunization Programs
DOI: 10.1002/bmb.70025
ISSN: 1470-8175
1539-3429
Abstract: Proteins are essential in biological systems, acting in transport, catalysis, and immune defense processes. However, these biomolecules' structural and functional complexity makes teaching and understanding these topics challenging. To address this difficulty, this study aimed to develop tutorials that facilitate learning and teaching about proteins based on structural analysis and molecular visualization through the interactions of the antigen-antibody complex. Thus, the ChimeraX platform was chosen as the central tool due to its intuitive interface and features that allow the manipulation and visualization of three-dimensional molecules, such as proteins, DNA, and chemical compounds, in .pdb format. The software combines visual and analytical functions, covering from basic to advanced aspects, adapting to the user's level of knowledge. The study presented three practical tutorials: (i) presentation of the tool, (ii) focusing on immunology, and (iii) addressing aspects of biochemistry. These tutorials demonstrated how to use ChimeraX to explore the relationship between protein structure and function, highlighting topics such as molecular interactions and other relevant biochemical processes. In addition, the Tutorials 1 and 2 were validated through the application in a microbiology undergraduate class, followed by a questionnaire and CVI analysis, which confirmed their clarity, relevance, and applicability, reinforcing their role as effective resources for integrating bioinformatics into health-related courses. Thus, the study contributes to disseminating knowledge methods and tools that enable more dynamic and accessible learning through visual and interactive approaches.
Abstractor: As Provided
Entry Date: 2026
Accession Number: EJ1496090
Database: ERIC
FullText Text:
  Availability: 0
Header DbId: eric
DbLabel: ERIC
An: EJ1496090
AccessLevel: 3
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Chimera X Interface to Enhance Understanding in Biochemistry and Immunology
– Name: Language
  Label: Language
  Group: Lang
  Data: English
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AR" term="%22Dalpiaz+Giovana%22">Dalpiaz Giovana</searchLink> (ORCID <externalLink term="https://orcid.org/0000-0003-0281-3171">0000-0003-0281-3171</externalLink>)<br /><searchLink fieldCode="AR" term="%22Krohn+Muriel+Schiling%22">Krohn Muriel Schiling</searchLink> (ORCID <externalLink term="https://orcid.org/0009-0000-2077-3615">0009-0000-2077-3615</externalLink>)<br /><searchLink fieldCode="AR" term="%22Groehs+Eduarda%22">Groehs Eduarda</searchLink> (ORCID <externalLink term="https://orcid.org/0009-0001-7140-8519">0009-0001-7140-8519</externalLink>)<br /><searchLink fieldCode="AR" term="%22Anjos+André+da+Silva%22">Anjos André da Silva</searchLink> (ORCID <externalLink term="https://orcid.org/0000-0003-3714-3171">0000-0003-3714-3171</externalLink>)<br /><searchLink fieldCode="AR" term="%22Meireles+R%2E+Mariana%22">Meireles R. Mariana</searchLink> (ORCID <externalLink term="https://orcid.org/0000-0002-2024-2846">0000-0002-2024-2846</externalLink>)
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="SO" term="%22Biochemistry+and+Molecular+Biology+Education%22"><i>Biochemistry and Molecular Biology Education</i></searchLink>. 2026 54(1):92-102.
– Name: Avail
  Label: Availability
  Group: Avail
  Data: Wiley. Available from: John Wiley & Sons, Inc. 111 River Street, Hoboken, NJ 07030. Tel: 800-835-6770; e-mail: cs-journals@wiley.com; Web site: https://www.wiley.com/en-us
– Name: PeerReviewed
  Label: Peer Reviewed
  Group: SrcInfo
  Data: Y
– Name: Pages
  Label: Page Count
  Group: Src
  Data: 11
– Name: DatePubCY
  Label: Publication Date
  Group: Date
  Data: 2026
– Name: TypeDocument
  Label: Document Type
  Group: TypDoc
  Data: Journal Articles<br />Reports - Research
– Name: Subject
  Label: Descriptors
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22Biochemistry%22">Biochemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Scientific+Concepts%22">Scientific Concepts</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+Structure%22">Molecular Structure</searchLink><br /><searchLink fieldCode="DE" term="%22Tutorial+Programs%22">Tutorial Programs</searchLink><br /><searchLink fieldCode="DE" term="%22Science+Instruction%22">Science Instruction</searchLink><br /><searchLink fieldCode="DE" term="%22Teaching+Methods%22">Teaching Methods</searchLink><br /><searchLink fieldCode="DE" term="%22Visualization%22">Visualization</searchLink><br /><searchLink fieldCode="DE" term="%22Computer+Software%22">Computer Software</searchLink><br /><searchLink fieldCode="DE" term="%22Computer+Simulation%22">Computer Simulation</searchLink><br /><searchLink fieldCode="DE" term="%22Genetics%22">Genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Immunization+Programs%22">Immunization Programs</searchLink>
– Name: DOI
  Label: DOI
  Group: ID
  Data: 10.1002/bmb.70025
– Name: ISSN
  Label: ISSN
  Group: ISSN
  Data: 1470-8175<br />1539-3429
– Name: Abstract
  Label: Abstract
  Group: Ab
  Data: Proteins are essential in biological systems, acting in transport, catalysis, and immune defense processes. However, these biomolecules' structural and functional complexity makes teaching and understanding these topics challenging. To address this difficulty, this study aimed to develop tutorials that facilitate learning and teaching about proteins based on structural analysis and molecular visualization through the interactions of the antigen-antibody complex. Thus, the ChimeraX platform was chosen as the central tool due to its intuitive interface and features that allow the manipulation and visualization of three-dimensional molecules, such as proteins, DNA, and chemical compounds, in .pdb format. The software combines visual and analytical functions, covering from basic to advanced aspects, adapting to the user's level of knowledge. The study presented three practical tutorials: (i) presentation of the tool, (ii) focusing on immunology, and (iii) addressing aspects of biochemistry. These tutorials demonstrated how to use ChimeraX to explore the relationship between protein structure and function, highlighting topics such as molecular interactions and other relevant biochemical processes. In addition, the Tutorials 1 and 2 were validated through the application in a microbiology undergraduate class, followed by a questionnaire and CVI analysis, which confirmed their clarity, relevance, and applicability, reinforcing their role as effective resources for integrating bioinformatics into health-related courses. Thus, the study contributes to disseminating knowledge methods and tools that enable more dynamic and accessible learning through visual and interactive approaches.
– Name: AbstractInfo
  Label: Abstractor
  Group: Ab
  Data: As Provided
– Name: DateEntry
  Label: Entry Date
  Group: Date
  Data: 2026
– Name: AN
  Label: Accession Number
  Group: ID
  Data: EJ1496090
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=eric&AN=EJ1496090
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1002/bmb.70025
    Languages:
      – Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 11
        StartPage: 92
    Subjects:
      – SubjectFull: Biochemistry
        Type: general
      – SubjectFull: Scientific Concepts
        Type: general
      – SubjectFull: Molecular Structure
        Type: general
      – SubjectFull: Tutorial Programs
        Type: general
      – SubjectFull: Science Instruction
        Type: general
      – SubjectFull: Teaching Methods
        Type: general
      – SubjectFull: Visualization
        Type: general
      – SubjectFull: Computer Software
        Type: general
      – SubjectFull: Computer Simulation
        Type: general
      – SubjectFull: Genetics
        Type: general
      – SubjectFull: Immunization Programs
        Type: general
    Titles:
      – TitleFull: Chimera X Interface to Enhance Understanding in Biochemistry and Immunology
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Dalpiaz Giovana
      – PersonEntity:
          Name:
            NameFull: Krohn Muriel Schiling
      – PersonEntity:
          Name:
            NameFull: Groehs Eduarda
      – PersonEntity:
          Name:
            NameFull: Anjos André da Silva
      – PersonEntity:
          Name:
            NameFull: Meireles R. Mariana
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 01
              Type: published
              Y: 2026
          Identifiers:
            – Type: issn-print
              Value: 1470-8175
            – Type: issn-electronic
              Value: 1539-3429
          Numbering:
            – Type: volume
              Value: 54
            – Type: issue
              Value: 1
          Titles:
            – TitleFull: Biochemistry and Molecular Biology Education
              Type: main
ResultId 1