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Maternal Prenatal Social Disadvantage and Neonatal Functional Connectivity: Associations with Psychopathology Symptoms at Age 12 Months

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Title: Maternal Prenatal Social Disadvantage and Neonatal Functional Connectivity: Associations with Psychopathology Symptoms at Age 12 Months
Language: English
Authors: Max P. Herzberg (ORCID 0000-0003-3177-7966), Ashley N. Nielsen, Rebecca Brady, Sydney Kaplan, Dimitrios Alexopoulos, Dominique Meyer, Jyoti Arora, J. Philip Miller, Tara A. Smyser, Deanna M. Barch, Cynthia E. Rogers, Barbara B. Warner, Christopher D. Smyser, Joan L. Luby
Source: Developmental Psychology. 2024 60(9):1562-1579.
Availability: American Psychological Association. Journals Department, 750 First Street NE, Washington, DC 20002. Tel: 800-374-2721; Tel: 202-336-5510; Fax: 202-336-5502; e-mail: order@apa.org; Web site: http://www.apa.org
Peer Reviewed: Y
Page Count: 18
Publication Date: 2024
Sponsoring Agency: National Institutes of Health (NIH) (DHHS)
Contract Number: R01MH113883
T32MH100019
Document Type: Journal Articles
Reports - Research
Descriptors: Mothers, Disadvantaged, Prenatal Influences, Psychopathology, Brain, Infants, Infant Behavior, Symptoms (Individual Disorders), Parent Background
Geographic Terms: Missouri (Saint Louis)
DOI: 10.1037/dev0001708
ISSN: 0012-1649
1939-0599
Abstract: Recent research has reported effects of socioeconomic status on neurobehavioral development as early as infancy, including positive associations between income and brain structure, functional connectivity, and behavior later in childhood (Ramphal, Whalen, et al., 2020; Triplett et al., 2022). This study extends this literature by investigating the relation of maternal prenatal social disadvantage (PSD) to neonatal amygdala and hippocampus functional connectivity and whether socioeconomic-related alterations in functional connectivity subsequently predict behavior at age 12 months in a large, socioeconomically diverse sample (N = 261 mother-infant dyads). PSD was assessed across gestation; neonatal magnetic resonance imaging was completed within the first weeks of life; and infant internalizing and externalizing symptoms were evaluated using the Infant-Toddler Social and Emotional Assessment at age 12 months. The results showed that PSD was significantly related to neonatal right amygdala and left hippocampus functional connectivity with prefrontal and motor-related regions. Social disadvantage-related right amygdala and left hippocampus functional connectivity with these regions was subsequently related to infant externalizing and internalizing symptoms at age 12 months. Building off an emerging literature exploring prenatal impacts on neonatal functional connectivity, this study further emphasizes the important role of the maternal environment during gestation on infant brain function and its relationship with externalizing and internalizing behavior in the first years of life. The results suggest that the prenatal socioeconomic environment may be a promising target for interventions aimed at improving infant neurobehavioral outcomes.
Abstractor: As Provided
Entry Date: 2026
Accession Number: EJ1500074
Database: ERIC
FullText Text:
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  Data: Maternal Prenatal Social Disadvantage and Neonatal Functional Connectivity: Associations with Psychopathology Symptoms at Age 12 Months
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  Data: English
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  Data: <searchLink fieldCode="AR" term="%22Max+P%2E+Herzberg%22">Max P. Herzberg</searchLink> (ORCID <externalLink term="https://orcid.org/0000-0003-3177-7966">0000-0003-3177-7966</externalLink>)<br /><searchLink fieldCode="AR" term="%22Ashley+N%2E+Nielsen%22">Ashley N. Nielsen</searchLink><br /><searchLink fieldCode="AR" term="%22Rebecca+Brady%22">Rebecca Brady</searchLink><br /><searchLink fieldCode="AR" term="%22Sydney+Kaplan%22">Sydney Kaplan</searchLink><br /><searchLink fieldCode="AR" term="%22Dimitrios+Alexopoulos%22">Dimitrios Alexopoulos</searchLink><br /><searchLink fieldCode="AR" term="%22Dominique+Meyer%22">Dominique Meyer</searchLink><br /><searchLink fieldCode="AR" term="%22Jyoti+Arora%22">Jyoti Arora</searchLink><br /><searchLink fieldCode="AR" term="%22J%2E+Philip+Miller%22">J. Philip Miller</searchLink><br /><searchLink fieldCode="AR" term="%22Tara+A%2E+Smyser%22">Tara A. Smyser</searchLink><br /><searchLink fieldCode="AR" term="%22Deanna+M%2E+Barch%22">Deanna M. Barch</searchLink><br /><searchLink fieldCode="AR" term="%22Cynthia+E%2E+Rogers%22">Cynthia E. Rogers</searchLink><br /><searchLink fieldCode="AR" term="%22Barbara+B%2E+Warner%22">Barbara B. Warner</searchLink><br /><searchLink fieldCode="AR" term="%22Christopher+D%2E+Smyser%22">Christopher D. Smyser</searchLink><br /><searchLink fieldCode="AR" term="%22Joan+L%2E+Luby%22">Joan L. Luby</searchLink>
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  Data: <searchLink fieldCode="SO" term="%22Developmental+Psychology%22"><i>Developmental Psychology</i></searchLink>. 2024 60(9):1562-1579.
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  Data: American Psychological Association. Journals Department, 750 First Street NE, Washington, DC 20002. Tel: 800-374-2721; Tel: 202-336-5510; Fax: 202-336-5502; e-mail: order@apa.org; Web site: http://www.apa.org
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  Data: 18
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  Data: 2024
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  Data: National Institutes of Health (NIH) (DHHS)
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  Data: <searchLink fieldCode="DE" term="%22Mothers%22">Mothers</searchLink><br /><searchLink fieldCode="DE" term="%22Disadvantaged%22">Disadvantaged</searchLink><br /><searchLink fieldCode="DE" term="%22Prenatal+Influences%22">Prenatal Influences</searchLink><br /><searchLink fieldCode="DE" term="%22Psychopathology%22">Psychopathology</searchLink><br /><searchLink fieldCode="DE" term="%22Brain%22">Brain</searchLink><br /><searchLink fieldCode="DE" term="%22Infants%22">Infants</searchLink><br /><searchLink fieldCode="DE" term="%22Infant+Behavior%22">Infant Behavior</searchLink><br /><searchLink fieldCode="DE" term="%22Symptoms+%28Individual+Disorders%29%22">Symptoms (Individual Disorders)</searchLink><br /><searchLink fieldCode="DE" term="%22Parent+Background%22">Parent Background</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22Missouri+%28Saint+Louis%29%22">Missouri (Saint Louis)</searchLink>
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  Data: 10.1037/dev0001708
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  Data: 0012-1649<br />1939-0599
– Name: Abstract
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  Data: Recent research has reported effects of socioeconomic status on neurobehavioral development as early as infancy, including positive associations between income and brain structure, functional connectivity, and behavior later in childhood (Ramphal, Whalen, et al., 2020; Triplett et al., 2022). This study extends this literature by investigating the relation of maternal prenatal social disadvantage (PSD) to neonatal amygdala and hippocampus functional connectivity and whether socioeconomic-related alterations in functional connectivity subsequently predict behavior at age 12 months in a large, socioeconomically diverse sample (N = 261 mother-infant dyads). PSD was assessed across gestation; neonatal magnetic resonance imaging was completed within the first weeks of life; and infant internalizing and externalizing symptoms were evaluated using the Infant-Toddler Social and Emotional Assessment at age 12 months. The results showed that PSD was significantly related to neonatal right amygdala and left hippocampus functional connectivity with prefrontal and motor-related regions. Social disadvantage-related right amygdala and left hippocampus functional connectivity with these regions was subsequently related to infant externalizing and internalizing symptoms at age 12 months. Building off an emerging literature exploring prenatal impacts on neonatal functional connectivity, this study further emphasizes the important role of the maternal environment during gestation on infant brain function and its relationship with externalizing and internalizing behavior in the first years of life. The results suggest that the prenatal socioeconomic environment may be a promising target for interventions aimed at improving infant neurobehavioral outcomes.
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  Data: 2026
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        PageCount: 18
        StartPage: 1562
    Subjects:
      – SubjectFull: Mothers
        Type: general
      – SubjectFull: Disadvantaged
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      – SubjectFull: Prenatal Influences
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      – SubjectFull: Psychopathology
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      – SubjectFull: Brain
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      – SubjectFull: Infants
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      – SubjectFull: Infant Behavior
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      – SubjectFull: Symptoms (Individual Disorders)
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      – SubjectFull: Parent Background
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      – SubjectFull: Missouri (Saint Louis)
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      – TitleFull: Maternal Prenatal Social Disadvantage and Neonatal Functional Connectivity: Associations with Psychopathology Symptoms at Age 12 Months
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