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Molecular Autism Research in Africa: Emerging Themes and Prevailing Disparities

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Title: Molecular Autism Research in Africa: Emerging Themes and Prevailing Disparities
Language: English
Authors: Emma Frickel, Caitlyn Mahony, Sophia Bam, Erin Buchanan, Mignon van der Watt, Colleen O'Ryan (ORCID 0000-0003-3719-4657)
Source: Review Journal of Autism and Developmental Disorders. 2025 12(4):666-682.
Availability: Springer. Available from: Springer Nature. One New York Plaza, Suite 4600, New York, NY 10004. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-460-1700; e-mail: customerservice@springernature.com; Web site: https://link.springer.com/
Peer Reviewed: Y
Page Count: 17
Publication Date: 2025
Document Type: Journal Articles
Information Analyses
Reports - Research
Descriptors: Foreign Countries, Autism Spectrum Disorders, Genetics, Molecular Structure, Genetic Disorders, Etiology, Research
Geographic Terms: South Africa
DOI: 10.1007/s40489-023-00415-0
ISSN: 2195-7177
2195-7185
Abstract: African populations are consistently underrepresented in molecular research on autism spectrum disorders (ASD). Yet, Africa's genetic diversity could reveal novel mechanisms associated with ASD etiology. We review the molecular ASD research from Africa between 2016-2022, highlighting region-specific limitations, opportunities, and areas of progress. We emphasize a need to advance null-hypothesis based molecular studies in Africa, particularly in critically understudied Sub-Saharan African (SSA) populations. Using South Africa as a case study, we show that this geographical disparity is not solely attributable to sociocultural barriers nor to an absence of molecular research infrastructure. We emphasize the importance of interdisciplinary collaboration within SSA and internationally to harness existing infrastructure for the expansion of molecular ASD research in Africa.
Abstractor: As Provided
Entry Date: 2026
Accession Number: EJ1502367
Database: ERIC
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  Data: <searchLink fieldCode="AR" term="%22Emma+Frickel%22">Emma Frickel</searchLink><br /><searchLink fieldCode="AR" term="%22Caitlyn+Mahony%22">Caitlyn Mahony</searchLink><br /><searchLink fieldCode="AR" term="%22Sophia+Bam%22">Sophia Bam</searchLink><br /><searchLink fieldCode="AR" term="%22Erin+Buchanan%22">Erin Buchanan</searchLink><br /><searchLink fieldCode="AR" term="%22Mignon+van+der+Watt%22">Mignon van der Watt</searchLink><br /><searchLink fieldCode="AR" term="%22Colleen+O'Ryan%22">Colleen O'Ryan</searchLink> (ORCID <externalLink term="http://orcid.org/0000-0003-3719-4657">0000-0003-3719-4657</externalLink>)
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  Data: Springer. Available from: Springer Nature. One New York Plaza, Suite 4600, New York, NY 10004. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-460-1700; e-mail: customerservice@springernature.com; Web site: https://link.springer.com/
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  Data: 17
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  Data: <searchLink fieldCode="DE" term="%22Foreign+Countries%22">Foreign Countries</searchLink><br /><searchLink fieldCode="DE" term="%22Autism+Spectrum+Disorders%22">Autism Spectrum Disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Genetics%22">Genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Molecular+Structure%22">Molecular Structure</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+Disorders%22">Genetic Disorders</searchLink><br /><searchLink fieldCode="DE" term="%22Etiology%22">Etiology</searchLink><br /><searchLink fieldCode="DE" term="%22Research%22">Research</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22South+Africa%22">South Africa</searchLink>
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  Data: 10.1007/s40489-023-00415-0
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  Data: African populations are consistently underrepresented in molecular research on autism spectrum disorders (ASD). Yet, Africa's genetic diversity could reveal novel mechanisms associated with ASD etiology. We review the molecular ASD research from Africa between 2016-2022, highlighting region-specific limitations, opportunities, and areas of progress. We emphasize a need to advance null-hypothesis based molecular studies in Africa, particularly in critically understudied Sub-Saharan African (SSA) populations. Using South Africa as a case study, we show that this geographical disparity is not solely attributable to sociocultural barriers nor to an absence of molecular research infrastructure. We emphasize the importance of interdisciplinary collaboration within SSA and internationally to harness existing infrastructure for the expansion of molecular ASD research in Africa.
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      – SubjectFull: South Africa
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