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A Comparative Study of Clinical Correlates in Schizophrenia with Onset in Childhood, Adolescence and Adulthood

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Title: A Comparative Study of Clinical Correlates in Schizophrenia with Onset in Childhood, Adolescence and Adulthood
Language: English
Authors: Biswas, Parthasarathy, Malhotra, Savita, Malhotra, Anil, Gupta, Nitin
Source: Journal of Indian Association for Child and Adolescent Mental Health. 2006 2(1):18-30.
Availability: Indian Association for Child and Adolescent Mental Health. e-mail: jiacam@gmail.com; Web site: http://www.jiacam.org
Peer Reviewed: Y
Page Count: 13
Publication Date: 2006
Document Type: Journal Articles
Reports - Research
Descriptors: Schizophrenia, Intelligence Quotient, Psychopathology, Children, Patients, Measures (Individuals), Genetics, Profiles, Foreign Countries, Correlation, Child Health, Age Differences, Adolescents, Adults, Comparative Analysis, Socioeconomic Influences, Demography, Individual Characteristics, Genetic Disorders, Academic Achievement, Symptoms (Individual Disorders), Self Destructive Behavior, Suicide, Drug Therapy, Behavior Disorders, Outcomes of Treatment
Geographic Terms: India
Assessment and Survey Identifiers: Wechsler Adult Intelligence Scale
ISSN: 0973-1342
Abstract: Background: Childhood onset schizophrenia (COS) is a rare disorder. Comparative data on the effect of differential age of onset on clinical profile in schizophrenia are very few. Method: Subjects with COS (n = 15), adolescence onset schizophrenia (AdOS, n = 20) and adulthood onset schizophrenia (AOS, n = 20) were compared on socio-demographic, clinical and genetic history parameters using Instrument for the Retrospective Assessment of the Onset of Schizophrenia (IRAOS), Positive and Negative Symptoms Scale (PANSS), Family Instrument for Genetic Studies (FIGS), Wechsler's Adult Intelligence Scale-Revised WAIS-R), Malin's Intelligence Scale for Indian Children (MISIC) and WHO Life Chart Schedule (WHO LCS). Results: Significantly higher rate of socioeconomic dependence, poorer academic performance, and non-paranoid subtype was seen in the COS group as compared to the AdOS and AOS. The total score on PANSS was maximum in the COS group with AdOS taking an intermediate position. COS patients had more somatic and obsessive symptoms whereas, AdOS patients had more self-injurious behaviour and suicidal attempts. The response to typical antipsychotic medication was poorer in the COS group as compared to the other two groups. In spite of treatment with atypical antipsychotics (including clozapine), 1/3rd of the COS patients continued to show limited response. The COS group scored least on the Mean IQ. The outcome was significantly poorer in patients of COS (33%), and it correlated significantly with low IQ. Conclusions: COS seems to be a more severe form of the schizophrenic illness with high degree of socioeconomic dependence, poorer response to treatment, greater and more florid psychopathology, poorer course and outcome, greater neurocognitive deficits and qualitative differences in the type of schizophrenia and non-specific symptom profile as compared to the later onset schizophrenias. (Contains 3 tables.)
Abstractor: As Provided
Number of References: 52
Entry Date: 2009
Accession Number: EJ840389
Database: ERIC
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  Data: A Comparative Study of Clinical Correlates in Schizophrenia with Onset in Childhood, Adolescence and Adulthood
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  Data: Indian Association for Child and Adolescent Mental Health. e-mail: jiacam@gmail.com; Web site: http://www.jiacam.org
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  Data: Background: Childhood onset schizophrenia (COS) is a rare disorder. Comparative data on the effect of differential age of onset on clinical profile in schizophrenia are very few. Method: Subjects with COS (n = 15), adolescence onset schizophrenia (AdOS, n = 20) and adulthood onset schizophrenia (AOS, n = 20) were compared on socio-demographic, clinical and genetic history parameters using Instrument for the Retrospective Assessment of the Onset of Schizophrenia (IRAOS), Positive and Negative Symptoms Scale (PANSS), Family Instrument for Genetic Studies (FIGS), Wechsler's Adult Intelligence Scale-Revised WAIS-R), Malin's Intelligence Scale for Indian Children (MISIC) and WHO Life Chart Schedule (WHO LCS). Results: Significantly higher rate of socioeconomic dependence, poorer academic performance, and non-paranoid subtype was seen in the COS group as compared to the AdOS and AOS. The total score on PANSS was maximum in the COS group with AdOS taking an intermediate position. COS patients had more somatic and obsessive symptoms whereas, AdOS patients had more self-injurious behaviour and suicidal attempts. The response to typical antipsychotic medication was poorer in the COS group as compared to the other two groups. In spite of treatment with atypical antipsychotics (including clozapine), 1/3rd of the COS patients continued to show limited response. The COS group scored least on the Mean IQ. The outcome was significantly poorer in patients of COS (33%), and it correlated significantly with low IQ. Conclusions: COS seems to be a more severe form of the schizophrenic illness with high degree of socioeconomic dependence, poorer response to treatment, greater and more florid psychopathology, poorer course and outcome, greater neurocognitive deficits and qualitative differences in the type of schizophrenia and non-specific symptom profile as compared to the later onset schizophrenias. (Contains 3 tables.)
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  Data: 2009
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  Data: EJ840389
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RecordInfo BibRecord:
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    Languages:
      – Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 13
        StartPage: 18
    Subjects:
      – SubjectFull: Schizophrenia
        Type: general
      – SubjectFull: Intelligence Quotient
        Type: general
      – SubjectFull: Psychopathology
        Type: general
      – SubjectFull: Children
        Type: general
      – SubjectFull: Patients
        Type: general
      – SubjectFull: Measures (Individuals)
        Type: general
      – SubjectFull: Genetics
        Type: general
      – SubjectFull: Profiles
        Type: general
      – SubjectFull: Foreign Countries
        Type: general
      – SubjectFull: Correlation
        Type: general
      – SubjectFull: Child Health
        Type: general
      – SubjectFull: Age Differences
        Type: general
      – SubjectFull: Adolescents
        Type: general
      – SubjectFull: Adults
        Type: general
      – SubjectFull: Comparative Analysis
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      – SubjectFull: Socioeconomic Influences
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      – SubjectFull: Demography
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      – SubjectFull: Individual Characteristics
        Type: general
      – SubjectFull: Genetic Disorders
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      – SubjectFull: Academic Achievement
        Type: general
      – SubjectFull: Symptoms (Individual Disorders)
        Type: general
      – SubjectFull: Self Destructive Behavior
        Type: general
      – SubjectFull: Suicide
        Type: general
      – SubjectFull: Drug Therapy
        Type: general
      – SubjectFull: Behavior Disorders
        Type: general
      – SubjectFull: Outcomes of Treatment
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      – SubjectFull: India
        Type: general
      – SubjectFull: Wechsler Adult Intelligence Scale
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      – TitleFull: A Comparative Study of Clinical Correlates in Schizophrenia with Onset in Childhood, Adolescence and Adulthood
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