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Neurobiology of Childhood-Onset Schizophrenia

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Title: Neurobiology of Childhood-Onset Schizophrenia
Language: English
Authors: Biswas, Parthasarathy
Source: Journal of Indian Association for Child and Adolescent Mental Health. 2008 4(3):55-61.
Availability: Indian Association for Child and Adolescent Mental Health. e-mail: jiacam@gmail.com; Web site: http://www.jiacam.org
Peer Reviewed: Y
Physical Description: PDF
Page Count: 7
Publication Date: 2008
Document Type: Journal Articles
Reports - Evaluative
Descriptors: Schizophrenia, Children, Patients, Neurology, Biology, Brain Hemisphere Functions, Measures (Individuals), Intelligence, Memory, Correlation, Psychopathology, Perceptual Motor Coordination, Genetics, Environmental Influences
ISSN: 0973-1342
Abstract: In the last decade there has been an exponential increase in studies on neurobiological measures in childhood-onset schizophrenia (COS). There seems to be a consensus that structural changes in COS are more marked than in adolescence-onset (AdOS) or adult-onset schizophrenia (AOS). Atrophy of total brain volume is progressive throughout the course in COS patients unlike later-onset types where it was static. Smaller than normal amounts of regional N-acetylaspartate (NAA) is reported in the hippocampus and dorsolateral prefrontal cortex in COS. There is non-suppression of primitive reflexes (neurological soft signs) with cortical maturation in patients with COS. COS patients showed significantly greater deficits on scales of IQ, memory and perceptuomotor skills as compared to patients with AdOS and AOS. This review also discusses the various correlations between biological measures and clinical and psychopathological variables.
Abstractor: As Provided
Number of References: 63
Entry Date: 2011
Accession Number: EJ942529
Database: ERIC
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  Data: Neurobiology of Childhood-Onset Schizophrenia
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  Data: Indian Association for Child and Adolescent Mental Health. e-mail: jiacam@gmail.com; Web site: http://www.jiacam.org
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  Data: <searchLink fieldCode="DE" term="%22Schizophrenia%22">Schizophrenia</searchLink><br /><searchLink fieldCode="DE" term="%22Children%22">Children</searchLink><br /><searchLink fieldCode="DE" term="%22Patients%22">Patients</searchLink><br /><searchLink fieldCode="DE" term="%22Neurology%22">Neurology</searchLink><br /><searchLink fieldCode="DE" term="%22Biology%22">Biology</searchLink><br /><searchLink fieldCode="DE" term="%22Brain+Hemisphere+Functions%22">Brain Hemisphere Functions</searchLink><br /><searchLink fieldCode="DE" term="%22Measures+%28Individuals%29%22">Measures (Individuals)</searchLink><br /><searchLink fieldCode="DE" term="%22Intelligence%22">Intelligence</searchLink><br /><searchLink fieldCode="DE" term="%22Memory%22">Memory</searchLink><br /><searchLink fieldCode="DE" term="%22Correlation%22">Correlation</searchLink><br /><searchLink fieldCode="DE" term="%22Psychopathology%22">Psychopathology</searchLink><br /><searchLink fieldCode="DE" term="%22Perceptual+Motor+Coordination%22">Perceptual Motor Coordination</searchLink><br /><searchLink fieldCode="DE" term="%22Genetics%22">Genetics</searchLink><br /><searchLink fieldCode="DE" term="%22Environmental+Influences%22">Environmental Influences</searchLink>
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  Data: In the last decade there has been an exponential increase in studies on neurobiological measures in childhood-onset schizophrenia (COS). There seems to be a consensus that structural changes in COS are more marked than in adolescence-onset (AdOS) or adult-onset schizophrenia (AOS). Atrophy of total brain volume is progressive throughout the course in COS patients unlike later-onset types where it was static. Smaller than normal amounts of regional N-acetylaspartate (NAA) is reported in the hippocampus and dorsolateral prefrontal cortex in COS. There is non-suppression of primitive reflexes (neurological soft signs) with cortical maturation in patients with COS. COS patients showed significantly greater deficits on scales of IQ, memory and perceptuomotor skills as compared to patients with AdOS and AOS. This review also discusses the various correlations between biological measures and clinical and psychopathological variables.
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  Data: 63
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  Data: 2011
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      – Text: English
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      – SubjectFull: Brain Hemisphere Functions
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      – SubjectFull: Measures (Individuals)
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      – SubjectFull: Intelligence
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      – SubjectFull: Memory
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      – SubjectFull: Genetics
        Type: general
      – SubjectFull: Environmental Influences
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      – TitleFull: Neurobiology of Childhood-Onset Schizophrenia
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