Application of Near-Infrared Spectroscopy in Early Detection of Antidepressant Treatment Efficacy in Major Depressive Disorder: A Longitudinal Study.
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| Title: | Application of Near-Infrared Spectroscopy in Early Detection of Antidepressant Treatment Efficacy in Major Depressive Disorder: A Longitudinal Study. |
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| Authors: | Jianjie Huang1, Jianmin Shan2 doctorshanjianmin@163.com |
| Source: | Actas Espanolas de Psiquiatria. 2025, Vol. 53 Issue 2, p275-283. 9p. |
| Subjects: | CONTINUOUS performance test, DEOXYHEMOGLOBIN, MENTAL depression, NEAR infrared spectroscopy, PROPENSITY score matching |
| Abstract: | Background: Major depressive disorder (MDD) is a prevalent and debilitating mental health condition, necessitating early detection and effective treatment strategies. Near-infrared spectroscopy (NIRS) is a promising neuroimaging technique for monitoring cerebral hemodynamics and may serve as an objective biomarker for MDD diagnosis and treatment efficacy. This study aimed to investigate the utility of NIRS in the early detection and longitudinal monitoring of antidepressant treatment efficacy in MDD patients. Methods: This longitudinal study, conducted from May 2022 to May 2024, included 138 participants. After propensity score matching analyses, 80 were included, including 40 MDD patients and 40 healthy controls matched for age, gender, race, education, height, weight, and body mass index (BMI). Participants underwent NIRS measurements during cognitive tasks, including verbal fluency, sustained attention (e-primer), and one-back memory tests. Clinical assessments were conducted using the Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), Clinical Global Impression (CGI), Continuous Performance Test (CPT), and one-back tests at baseline and after treatment at 4 weeks and 24 weeks. Statistical analyses were performed to evaluate changes in oxygenated hemoglobin (HbO) and deoxygenated hemoglobin (HbR) levels and their correlation with clinical outcomes. Submitted: 29 May 2024 Revised: 18 July 2024 Accepted: 25 July 2024 Published: 5 March 2025 *Corresponding author details: Jianmin Shan, Severe Female Ward, Wenzhou Seventh People's Hospital, 325000 Wenzhou, Zhejiang, China. Email: doctorshanjianmin@163.com Results: At baseline, MDD patients had significantly lower HbO and higher HbR levels compared to controls (p < 0.01). After treatment, HbO increased (4.77 ± 1.23 to 5.37 ± 1.21 µmol/L, p < 0.05) while HbR decreased (3.46 ±0.98 to 2.91±0.96 µmol/L, p<0.05) in the MDD group. However, these levels differed significantly from controls at 4 weeks (p < 0.01). By 24 weeks, HbO further increased (6.01 ± 1.08 µmol/L, p < 0.05), and HbR further decreased (2.19 ± 0.71 µmol/L, p < 0.05), with no significant differences from controls (p > 0.05). Clinically, MDD patients showed significant improvements in HAMD, HAMA, CGI, CPT, and one-back scores over 24 weeks (all p < 0.05). At 4 weeks, HAMD, HAMA, and CGI scores were higher, and CPT and one-back responses were lower than controls (p < 0.01). By 24 weeks, HAMD, HAMA, and CGI scores remained higher (p < 0.01), and CPT and one-back responses were lower than controls (p < 0.01). Conclusion: This study underscores the potential of NIRS as a non-invasive, objective tool for early detection and monitoring of treatment efficacy in MDD. The significant correlations between NIRS findings and clinical improvements highlight its utility in personalized treatment strategies, paving the way for more effective management of MDD. [ABSTRACT FROM AUTHOR] |
| Copyright of Actas Espanolas de Psiquiatria is the property of Maria Lopez-Ibor and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
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| Items | – Name: Title Label: Title Group: Ti Data: Application of Near-Infrared Spectroscopy in Early Detection of Antidepressant Treatment Efficacy in Major Depressive Disorder: A Longitudinal Study. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Jianjie+Huang%22">Jianjie Huang</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Jianmin+Shan%22">Jianmin Shan</searchLink><relatesTo>2</relatesTo><i> doctorshanjianmin@163.com</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Actas+Espanolas+de+Psiquiatria%22">Actas Espanolas de Psiquiatria</searchLink>. 2025, Vol. 53 Issue 2, p275-283. 9p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22CONTINUOUS+performance+test%22">CONTINUOUS performance test</searchLink><br /><searchLink fieldCode="DE" term="%22DEOXYHEMOGLOBIN%22">DEOXYHEMOGLOBIN</searchLink><br /><searchLink fieldCode="DE" term="%22MENTAL+depression%22">MENTAL depression</searchLink><br /><searchLink fieldCode="DE" term="%22NEAR+infrared+spectroscopy%22">NEAR infrared spectroscopy</searchLink><br /><searchLink fieldCode="DE" term="%22PROPENSITY+score+matching%22">PROPENSITY score matching</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: Major depressive disorder (MDD) is a prevalent and debilitating mental health condition, necessitating early detection and effective treatment strategies. Near-infrared spectroscopy (NIRS) is a promising neuroimaging technique for monitoring cerebral hemodynamics and may serve as an objective biomarker for MDD diagnosis and treatment efficacy. This study aimed to investigate the utility of NIRS in the early detection and longitudinal monitoring of antidepressant treatment efficacy in MDD patients. Methods: This longitudinal study, conducted from May 2022 to May 2024, included 138 participants. After propensity score matching analyses, 80 were included, including 40 MDD patients and 40 healthy controls matched for age, gender, race, education, height, weight, and body mass index (BMI). Participants underwent NIRS measurements during cognitive tasks, including verbal fluency, sustained attention (e-primer), and one-back memory tests. Clinical assessments were conducted using the Hamilton Depression Scale (HAMD), Hamilton Anxiety Scale (HAMA), Clinical Global Impression (CGI), Continuous Performance Test (CPT), and one-back tests at baseline and after treatment at 4 weeks and 24 weeks. Statistical analyses were performed to evaluate changes in oxygenated hemoglobin (HbO) and deoxygenated hemoglobin (HbR) levels and their correlation with clinical outcomes. Submitted: 29 May 2024 Revised: 18 July 2024 Accepted: 25 July 2024 Published: 5 March 2025 *Corresponding author details: Jianmin Shan, Severe Female Ward, Wenzhou Seventh People's Hospital, 325000 Wenzhou, Zhejiang, China. Email: doctorshanjianmin@163.com Results: At baseline, MDD patients had significantly lower HbO and higher HbR levels compared to controls (p < 0.01). After treatment, HbO increased (4.77 ± 1.23 to 5.37 ± 1.21 µmol/L, p < 0.05) while HbR decreased (3.46 ±0.98 to 2.91±0.96 µmol/L, p<0.05) in the MDD group. However, these levels differed significantly from controls at 4 weeks (p < 0.01). By 24 weeks, HbO further increased (6.01 ± 1.08 µmol/L, p < 0.05), and HbR further decreased (2.19 ± 0.71 µmol/L, p < 0.05), with no significant differences from controls (p > 0.05). Clinically, MDD patients showed significant improvements in HAMD, HAMA, CGI, CPT, and one-back scores over 24 weeks (all p < 0.05). At 4 weeks, HAMD, HAMA, and CGI scores were higher, and CPT and one-back responses were lower than controls (p < 0.01). By 24 weeks, HAMD, HAMA, and CGI scores remained higher (p < 0.01), and CPT and one-back responses were lower than controls (p < 0.01). Conclusion: This study underscores the potential of NIRS as a non-invasive, objective tool for early detection and monitoring of treatment efficacy in MDD. The significant correlations between NIRS findings and clinical improvements highlight its utility in personalized treatment strategies, paving the way for more effective management of MDD. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Actas Espanolas de Psiquiatria is the property of Maria Lopez-Ibor and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.62641/aep.v53i2.1708 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 9 StartPage: 275 Subjects: – SubjectFull: CONTINUOUS performance test Type: general – SubjectFull: DEOXYHEMOGLOBIN Type: general – SubjectFull: MENTAL depression Type: general – SubjectFull: NEAR infrared spectroscopy Type: general – SubjectFull: PROPENSITY score matching Type: general Titles: – TitleFull: Application of Near-Infrared Spectroscopy in Early Detection of Antidepressant Treatment Efficacy in Major Depressive Disorder: A Longitudinal Study. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Jianjie Huang – PersonEntity: Name: NameFull: Jianmin Shan IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 03 Text: 2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 11399287 Numbering: – Type: volume Value: 53 – Type: issue Value: 2 Titles: – TitleFull: Actas Espanolas de Psiquiatria Type: main |
| ResultId | 1 |
