Positive Impact of Holistic Nursing on Cognitive Impairment and Psychiatric Symptoms in Patients With Alzheimer's Disease.
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| Title: | Positive Impact of Holistic Nursing on Cognitive Impairment and Psychiatric Symptoms in Patients With Alzheimer's Disease. |
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| Authors: | Jie Yu1, Lin Zhu2, Yanan Song3, Biyan Shi3, Xiaoping Zhou3 13591253112@sina.cn |
| Source: | Actas Espanolas de Psiquiatria. 2025, Vol. 53 Issue 3, p586-597. 12p. |
| Subjects: | MONTREAL Cognitive Assessment, HOLISTIC nursing, PATIENT compliance, ALZHEIMER'S disease, ENZYME-linked immunosorbent assay |
| Abstract: | Background: Alzheimer's Disease (AD) affects millions of elderly individuals worldwide and has been clinically recognized as one of the most significant disorders compromising quality of life in late-stage human development. The objective of this study is to systematically evaluate the influence of holistic nursing (HN) on patients with AD, thereby providing evidence-based references for clinical practice. Methods: A total of 105 patients with AD hospitalized in our hospital between January 2023 and January 2024 were enrolled for prospective analysis. Among them, 58 received conventional care (control group), and 47 received HN (observation group). Before and following the nursing interventions, both groups underwent assessment using the Mini-Mental State Examination (MMSE), Neuropsychiatric Inventory (NPI), Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-cog), Montreal Cognitive Assessment (MoCA), and Self-rating Anxiety/Depression Scales (SAS/SDS). In addition, neurotransmitter levels and neuroinflammatory markers were measured using enzyme-linked immunosorbent assay and fully automated chemiluminescent immunoassay. Treatment compliance, incidence of adverse events, and family satisfaction were also recorded and compared between the two groups. Results: After nursing interventions, the observation group demonstrated significantly higher MMSE and MoCA scores compared to the control group. Conversely, NPI, ADAS-cog, SAS, and SDS scores were notably lower in the observation group (p < 0.05). Furthermore, neurotransmitter levels were significantly elevated in the observation group, while the concentrations of central nervous system-specific protein β (S100β) and interleukin-1β (IL-1β) were significantly reduced (p < 0.05). Although the incidence of adverse events did not differ significantly between the two groups (p > 0.05), the observation group exhibited higher treatment compliance and greater family satisfaction (p < 0.05). Conclusion: HN effectively improves cognitive function and alleviates psychiatric symptoms in AD patients, supporting its recommendation for clinical application. Clinical Trial Registration: No. NCT06868004. [ABSTRACT FROM AUTHOR] |
| Copyright of Actas Espanolas de Psiquiatria is the property of Maria Lopez-Ibor and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) | |
| Database: | MedicLatina |
| FullText | Links: – Type: pdflink Text: Availability: 0 |
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| Header | DbId: lth DbLabel: MedicLatina An: 185791992 AccessLevel: 6 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Positive Impact of Holistic Nursing on Cognitive Impairment and Psychiatric Symptoms in Patients With Alzheimer's Disease. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Jie+Yu%22">Jie Yu</searchLink><relatesTo>1</relatesTo><br /><searchLink fieldCode="AR" term="%22Lin+Zhu%22">Lin Zhu</searchLink><relatesTo>2</relatesTo><br /><searchLink fieldCode="AR" term="%22Yanan+Song%22">Yanan Song</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Biyan+Shi%22">Biyan Shi</searchLink><relatesTo>3</relatesTo><br /><searchLink fieldCode="AR" term="%22Xiaoping+Zhou%22">Xiaoping Zhou</searchLink><relatesTo>3</relatesTo><i> 13591253112@sina.cn</i> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%22Actas+Espanolas+de+Psiquiatria%22">Actas Espanolas de Psiquiatria</searchLink>. 2025, Vol. 53 Issue 3, p586-597. 12p. – Name: Subject Label: Subjects Group: Su Data: <searchLink fieldCode="DE" term="%22MONTREAL+Cognitive+Assessment%22">MONTREAL Cognitive Assessment</searchLink><br /><searchLink fieldCode="DE" term="%22HOLISTIC+nursing%22">HOLISTIC nursing</searchLink><br /><searchLink fieldCode="DE" term="%22PATIENT+compliance%22">PATIENT compliance</searchLink><br /><searchLink fieldCode="DE" term="%22ALZHEIMER'S+disease%22">ALZHEIMER'S disease</searchLink><br /><searchLink fieldCode="DE" term="%22ENZYME-linked+immunosorbent+assay%22">ENZYME-linked immunosorbent assay</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: Alzheimer's Disease (AD) affects millions of elderly individuals worldwide and has been clinically recognized as one of the most significant disorders compromising quality of life in late-stage human development. The objective of this study is to systematically evaluate the influence of holistic nursing (HN) on patients with AD, thereby providing evidence-based references for clinical practice. Methods: A total of 105 patients with AD hospitalized in our hospital between January 2023 and January 2024 were enrolled for prospective analysis. Among them, 58 received conventional care (control group), and 47 received HN (observation group). Before and following the nursing interventions, both groups underwent assessment using the Mini-Mental State Examination (MMSE), Neuropsychiatric Inventory (NPI), Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-cog), Montreal Cognitive Assessment (MoCA), and Self-rating Anxiety/Depression Scales (SAS/SDS). In addition, neurotransmitter levels and neuroinflammatory markers were measured using enzyme-linked immunosorbent assay and fully automated chemiluminescent immunoassay. Treatment compliance, incidence of adverse events, and family satisfaction were also recorded and compared between the two groups. Results: After nursing interventions, the observation group demonstrated significantly higher MMSE and MoCA scores compared to the control group. Conversely, NPI, ADAS-cog, SAS, and SDS scores were notably lower in the observation group (p < 0.05). Furthermore, neurotransmitter levels were significantly elevated in the observation group, while the concentrations of central nervous system-specific protein β (S100β) and interleukin-1β (IL-1β) were significantly reduced (p < 0.05). Although the incidence of adverse events did not differ significantly between the two groups (p > 0.05), the observation group exhibited higher treatment compliance and greater family satisfaction (p < 0.05). Conclusion: HN effectively improves cognitive function and alleviates psychiatric symptoms in AD patients, supporting its recommendation for clinical application. Clinical Trial Registration: No. NCT06868004. [ABSTRACT FROM AUTHOR] – Name: AbstractSuppliedCopyright Label: Group: Ab Data: <i>Copyright of Actas Espanolas de Psiquiatria is the property of Maria Lopez-Ibor and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.62641/aep.v53i3.1948 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 12 StartPage: 586 Subjects: – SubjectFull: MONTREAL Cognitive Assessment Type: general – SubjectFull: HOLISTIC nursing Type: general – SubjectFull: PATIENT compliance Type: general – SubjectFull: ALZHEIMER'S disease Type: general – SubjectFull: ENZYME-linked immunosorbent assay Type: general Titles: – TitleFull: Positive Impact of Holistic Nursing on Cognitive Impairment and Psychiatric Symptoms in Patients With Alzheimer's Disease. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Jie Yu – PersonEntity: Name: NameFull: Lin Zhu – PersonEntity: Name: NameFull: Yanan Song – PersonEntity: Name: NameFull: Biyan Shi – PersonEntity: Name: NameFull: Xiaoping Zhou IsPartOfRelationships: – BibEntity: Dates: – D: 01 M: 05 Text: 2025 Type: published Y: 2025 Identifiers: – Type: issn-print Value: 11399287 Numbering: – Type: volume Value: 53 – Type: issue Value: 3 Titles: – TitleFull: Actas Espanolas de Psiquiatria Type: main |
| ResultId | 1 |
