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Family-based Association Study of 5-HTTLPR/SLC6A4 and uVNTR/MAOA Polymorphisms in Patients with a History of Suicide Attempts.

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Title: Family-based Association Study of 5-HTTLPR/SLC6A4 and uVNTR/MAOA Polymorphisms in Patients with a History of Suicide Attempts.
Alternate Title: Estudio de asociación basado en familias de los polimorfismos 5-TTLPR/SLC6A4 y uVNTR/MAOA en pacientes con antecedente de intento suicida.
Authors: Sarmiento-Hernández, Emmanuel1 (AUTHOR), Fresán-Orellana, Ana2 (AUTHOR), Camarena-Medellin, Beatriz2 (AUTHOR) camare@inprf.gob.mx, Sanabrais-Jiménez, Marco Antonio2 (AUTHOR), Hernández-Muñoz, Sandra3 (AUTHOR), Aguilar-García, Alejandro2 (AUTHOR), Medina-Rodríguez, José Carlos4 (AUTHOR)
Source: Salud Mental. Nov/Dec2025, Vol. 48 Issue 6, p291-296. 6p.
Subjects: ATTEMPTED suicide, SEROTONIN transporters, HEREDITY, MONOAMINE oxidase inhibitors, GENETICS, GENETIC polymorphisms, AFFECTIVE disorders
Abstract (English): Introduction: Biological factors, especially genetic ones, are associated with the development of suicidal behavior. A 1.7- to 10.6-fold risk of developing suicidal behavior has been observed in individuals with first- or second-degree relatives with suicidal behavior. It has been suggested that the serotonergic and dopaminergic systems are involved in suicide attempts, particularly the SLC6A4 and MAOA genes. Objective: To analyze the allele transmission of 5-HTTLPR/SLC6A4 and uVNTR/MAOA polymorphisms in families with suicide attempts. Method: Fifty families with proband with a history of suicide attempts were included. All participants were recruited at the Ramón de la Fuente Muniz National Institute of Psychiatry and evaluated using the International Neuropsychiatric Interview (M.I.N.I.). Allele transmission analysis of the 5-HTTLPR and uVNTR polymorphisms was performed using the Haploview program. Results: Analysis of allele transmission of the 5-HTTLPR/SLC6A4 polymorphism showed greater transmission of the S allele in probands (χ2 = 6.6, p =.0098) with a previous suicide attempt and in those with two or more suicide attempts (χ2 = 5.4, p =.019). There was no observed preference in uVNTR/MAOA allele transmission. Discussion and conclusion: Our data support the hypothesis that the serotonin transporter is implicated in the development of suicide attempts in Mexican patients with mood disorders. [ABSTRACT FROM AUTHOR]
Abstract (Spanish): Introducción: Los factores biológicos, principalmente los genéticos, se encuentran vinculados al desarrollo de la conducta suicida. Se ha observado un incremento de 1.7 a 10.6 veces el riesgo a desarrollar conducta suicida en individuos con antecedentes de familiares de primer o segundo grado con conducta suicida. Se sugiere que el sistemas serotoninérgico y dopaminérgico se encuentran implicados con el intento suicida, destacando los genes SLC6A4 y MAOA. Objetivo: Analizar la transmisión de los alelos de los polimorfismos 5-HTTLPR/SLC6A4 y uVNTR/MAOA en familias con intento suicida. Método: Se incluyeron cincuenta familias donde el probando tenía el antecedente de intento suicida. Todos los participantes fueron obtenidos en el Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz evaluados con la Entrevista Neuropsiquiátrica Internacional (M.I.N.I.). El análisis de transmisión de alelos de los polimorfismos 5-HTTLPR y uVNTR se realizó mediante el uso del programa Haploview. Resultados: El análisis del polimorfismo 5-HTTLPR/SLC6A4 mostró una mayor transmisión del alelo S en los probandos con un intento suicida previo (χ2 = 6.6, p =.0098) y en aquellos con dos o más intentos suicidas (χ2 = 5.4, p =.019). No se observó la transmisión preferente de algún alelo del polimorfismo uVNTR/MAOA en la muestra analizada. Discusión y conclusión: Nuestros datos respaldan la hipotesis de que el transportador de serotonina se encuentra implicado con el desarrollo del intento suicida en pacientes mexicanos con trastornos del ánimo. [ABSTRACT FROM AUTHOR]
Copyright of Salud Mental is the property of Instituto Nacional de Psiquiatria Ramon de la Fuente and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
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  Data: Family-based Association Study of 5-HTTLPR/SLC6A4 and uVNTR/MAOA Polymorphisms in Patients with a History of Suicide Attempts.
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  Label: Alternate Title
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  Data: Estudio de asociación basado en familias de los polimorfismos 5-TTLPR/SLC6A4 y uVNTR/MAOA en pacientes con antecedente de intento suicida.
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  Data: <searchLink fieldCode="AR" term="%22Sarmiento-Hernández%2C+Emmanuel%22">Sarmiento-Hernández, Emmanuel</searchLink><relatesTo>1</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Fresán-Orellana%2C+Ana%22">Fresán-Orellana, Ana</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Camarena-Medellin%2C+Beatriz%22">Camarena-Medellin, Beatriz</searchLink><relatesTo>2</relatesTo> (AUTHOR)<i> camare@inprf.gob.mx</i><br /><searchLink fieldCode="AR" term="%22Sanabrais-Jiménez%2C+Marco+Antonio%22">Sanabrais-Jiménez, Marco Antonio</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Hernández-Muñoz%2C+Sandra%22">Hernández-Muñoz, Sandra</searchLink><relatesTo>3</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Aguilar-García%2C+Alejandro%22">Aguilar-García, Alejandro</searchLink><relatesTo>2</relatesTo> (AUTHOR)<br /><searchLink fieldCode="AR" term="%22Medina-Rodríguez%2C+José+Carlos%22">Medina-Rodríguez, José Carlos</searchLink><relatesTo>4</relatesTo> (AUTHOR)
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  Data: <searchLink fieldCode="JN" term="%22Salud+Mental%22">Salud Mental</searchLink>. Nov/Dec2025, Vol. 48 Issue 6, p291-296. 6p.
– Name: Subject
  Label: Subjects
  Group: Su
  Data: <searchLink fieldCode="DE" term="%22ATTEMPTED+suicide%22">ATTEMPTED suicide</searchLink><br /><searchLink fieldCode="DE" term="%22SEROTONIN+transporters%22">SEROTONIN transporters</searchLink><br /><searchLink fieldCode="DE" term="%22HEREDITY%22">HEREDITY</searchLink><br /><searchLink fieldCode="DE" term="%22MONOAMINE+oxidase+inhibitors%22">MONOAMINE oxidase inhibitors</searchLink><br /><searchLink fieldCode="DE" term="%22GENETICS%22">GENETICS</searchLink><br /><searchLink fieldCode="DE" term="%22GENETIC+polymorphisms%22">GENETIC polymorphisms</searchLink><br /><searchLink fieldCode="DE" term="%22AFFECTIVE+disorders%22">AFFECTIVE disorders</searchLink>
– Name: Abstract
  Label: Abstract (English)
  Group: Ab
  Data: Introduction: Biological factors, especially genetic ones, are associated with the development of suicidal behavior. A 1.7- to 10.6-fold risk of developing suicidal behavior has been observed in individuals with first- or second-degree relatives with suicidal behavior. It has been suggested that the serotonergic and dopaminergic systems are involved in suicide attempts, particularly the SLC6A4 and MAOA genes. Objective: To analyze the allele transmission of 5-HTTLPR/SLC6A4 and uVNTR/MAOA polymorphisms in families with suicide attempts. Method: Fifty families with proband with a history of suicide attempts were included. All participants were recruited at the Ramón de la Fuente Muniz National Institute of Psychiatry and evaluated using the International Neuropsychiatric Interview (M.I.N.I.). Allele transmission analysis of the 5-HTTLPR and uVNTR polymorphisms was performed using the Haploview program. Results: Analysis of allele transmission of the 5-HTTLPR/SLC6A4 polymorphism showed greater transmission of the S allele in probands (χ2 = 6.6, p =.0098) with a previous suicide attempt and in those with two or more suicide attempts (χ2 = 5.4, p =.019). There was no observed preference in uVNTR/MAOA allele transmission. Discussion and conclusion: Our data support the hypothesis that the serotonin transporter is implicated in the development of suicide attempts in Mexican patients with mood disorders. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label: Abstract (Spanish)
  Group: Ab
  Data: Introducción: Los factores biológicos, principalmente los genéticos, se encuentran vinculados al desarrollo de la conducta suicida. Se ha observado un incremento de 1.7 a 10.6 veces el riesgo a desarrollar conducta suicida en individuos con antecedentes de familiares de primer o segundo grado con conducta suicida. Se sugiere que el sistemas serotoninérgico y dopaminérgico se encuentran implicados con el intento suicida, destacando los genes SLC6A4 y MAOA. Objetivo: Analizar la transmisión de los alelos de los polimorfismos 5-HTTLPR/SLC6A4 y uVNTR/MAOA en familias con intento suicida. Método: Se incluyeron cincuenta familias donde el probando tenía el antecedente de intento suicida. Todos los participantes fueron obtenidos en el Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz evaluados con la Entrevista Neuropsiquiátrica Internacional (M.I.N.I.). El análisis de transmisión de alelos de los polimorfismos 5-HTTLPR y uVNTR se realizó mediante el uso del programa Haploview. Resultados: El análisis del polimorfismo 5-HTTLPR/SLC6A4 mostró una mayor transmisión del alelo S en los probandos con un intento suicida previo (χ2 = 6.6, p =.0098) y en aquellos con dos o más intentos suicidas (χ2 = 5.4, p =.019). No se observó la transmisión preferente de algún alelo del polimorfismo uVNTR/MAOA en la muestra analizada. Discusión y conclusión: Nuestros datos respaldan la hipotesis de que el transportador de serotonina se encuentra implicado con el desarrollo del intento suicida en pacientes mexicanos con trastornos del ánimo. [ABSTRACT FROM AUTHOR]
– Name: AbstractSuppliedCopyright
  Label:
  Group: Ab
  Data: <i>Copyright of Salud Mental is the property of Instituto Nacional de Psiquiatria Ramon de la Fuente and its content may not be copied or emailed to multiple sites without the copyright holder's express written permission. Additionally, content may not be used with any artificial intelligence tools or machine learning technologies. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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      – Type: doi
        Value: 10.17711/SM.0185-3325.2025.034
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      – Code: eng
        Text: English
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        PageCount: 6
        StartPage: 291
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      – SubjectFull: ATTEMPTED suicide
        Type: general
      – SubjectFull: SEROTONIN transporters
        Type: general
      – SubjectFull: HEREDITY
        Type: general
      – SubjectFull: MONOAMINE oxidase inhibitors
        Type: general
      – SubjectFull: GENETICS
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      – SubjectFull: GENETIC polymorphisms
        Type: general
      – SubjectFull: AFFECTIVE disorders
        Type: general
    Titles:
      – TitleFull: Family-based Association Study of 5-HTTLPR/SLC6A4 and uVNTR/MAOA Polymorphisms in Patients with a History of Suicide Attempts.
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              M: 11
              Text: Nov/Dec2025
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