Improvement of physiochemical properties of the tetrahydroazepinoindole series of farnesoid X receptor (FXR) agonists: beneficial modulation of lipids in primates.
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| Title: | Improvement of physiochemical properties of the tetrahydroazepinoindole series of farnesoid X receptor (FXR) agonists: beneficial modulation of lipids in primates. |
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| Authors: | Lundquist JT; Department of Chemical Sciences, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA. lundquj@wyeth.com, Harnish DC, Kim CY, Mehlmann JF, Unwalla RJ, Phipps KM, Crawley ML, Commons T, Green DM, Xu W, Hum WT, Eta JE, Feingold I, Patel V, Evans MJ, Lai K, Borges-Marcucci L, Mahaney PE, Wrobel JE |
| Source: | Journal of medicinal chemistry [J Med Chem] 2010 Feb 25; Vol. 53 (4), pp. 1774-87. |
| Publication Type: | Journal Article |
| Journal Info: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
| FullText | Text: Availability: 0 |
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| Header | DbId: mdl DbLabel: MEDLINE Ultimate An: 20095622 AccessLevel: 2 PubType: Academic Journal PubTypeId: academicJournal PreciseRelevancyScore: 0 |
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| Items | – Name: Title Label: Title Group: Ti Data: Improvement of physiochemical properties of the tetrahydroazepinoindole series of farnesoid X receptor (FXR) agonists: beneficial modulation of lipids in primates. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AU" term="%22Lundquist+JT%22">Lundquist JT</searchLink>; Department of Chemical Sciences, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA. lundquj@wyeth.com<br /><searchLink fieldCode="AU" term="%22Harnish+DC%22">Harnish DC</searchLink><br /><searchLink fieldCode="AU" term="%22Kim+CY%22">Kim CY</searchLink><br /><searchLink fieldCode="AU" term="%22Mehlmann+JF%22">Mehlmann JF</searchLink><br /><searchLink fieldCode="AU" term="%22Unwalla+RJ%22">Unwalla RJ</searchLink><br /><searchLink fieldCode="AU" term="%22Phipps+KM%22">Phipps KM</searchLink><br /><searchLink fieldCode="AU" term="%22Crawley+ML%22">Crawley ML</searchLink><br /><searchLink fieldCode="AU" term="%22Commons+T%22">Commons T</searchLink><br /><searchLink fieldCode="AU" term="%22Green+DM%22">Green DM</searchLink><br /><searchLink fieldCode="AU" term="%22Xu+W%22">Xu W</searchLink><br /><searchLink fieldCode="AU" term="%22Hum+WT%22">Hum WT</searchLink><br /><searchLink fieldCode="AU" term="%22Eta+JE%22">Eta JE</searchLink><br /><searchLink fieldCode="AU" term="%22Feingold+I%22">Feingold I</searchLink><br /><searchLink fieldCode="AU" term="%22Patel+V%22">Patel V</searchLink><br /><searchLink fieldCode="AU" term="%22Evans+MJ%22">Evans MJ</searchLink><br /><searchLink fieldCode="AU" term="%22Lai+K%22">Lai K</searchLink><br /><searchLink fieldCode="AU" term="%22Borges-Marcucci+L%22">Borges-Marcucci L</searchLink><br /><searchLink fieldCode="AU" term="%22Mahaney+PE%22">Mahaney PE</searchLink><br /><searchLink fieldCode="AU" term="%22Wrobel+JE%22">Wrobel JE</searchLink> – Name: TitleSource Label: Source Group: Src Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2010 Feb 25; Vol. 53 (4), pp. 1774-87. – Name: TypePub Label: Publication Type Group: TypPub Data: Journal Article – Name: TitleSource Label: Journal Info Group: Src Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE |
| PLink | https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=20095622 |
| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1021/jm901650u Languages: – Code: eng Text: English PhysicalDescription: Pagination: StartPage: 1774 Titles: – TitleFull: Improvement of physiochemical properties of the tetrahydroazepinoindole series of farnesoid X receptor (FXR) agonists: beneficial modulation of lipids in primates. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Lundquist JT – PersonEntity: Name: NameFull: Harnish DC – PersonEntity: Name: NameFull: Kim CY – PersonEntity: Name: NameFull: Mehlmann JF – PersonEntity: Name: NameFull: Unwalla RJ – PersonEntity: Name: NameFull: Phipps KM – PersonEntity: Name: NameFull: Crawley ML – PersonEntity: Name: NameFull: Commons T – PersonEntity: Name: NameFull: Green DM – PersonEntity: Name: NameFull: Xu W – PersonEntity: Name: NameFull: Hum WT – PersonEntity: Name: NameFull: Eta JE – PersonEntity: Name: NameFull: Feingold I – PersonEntity: Name: NameFull: Patel V – PersonEntity: Name: NameFull: Evans MJ – PersonEntity: Name: NameFull: Lai K – PersonEntity: Name: NameFull: Borges-Marcucci L – PersonEntity: Name: NameFull: Mahaney PE – PersonEntity: Name: NameFull: Wrobel JE IsPartOfRelationships: – BibEntity: Dates: – D: 25 M: 02 Text: 2010 Feb 25 Type: published Y: 2010 Identifiers: – Type: issn-electronic Value: 1520-4804 Numbering: – Type: volume Value: 53 – Type: issue Value: 4 Titles: – TitleFull: Journal of medicinal chemistry Type: main |
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