View in EDS

Discovery of novel hepatoselective HMG-CoA reductase inhibitors for treating hypercholesterolemia: a bench-to-bedside case study on tissue selective drug distribution.

Saved in:
Bibliographic Details
Title: Discovery of novel hepatoselective HMG-CoA reductase inhibitors for treating hypercholesterolemia: a bench-to-bedside case study on tissue selective drug distribution.
Authors: Pfefferkorn JA; Pfizer Global Research & Development, Eastern Point Road, Groton, CT 06340, USA. jeffrey.a.pfefferkorn@pfizer.com, Litchfield J, Hutchings R, Cheng XM, Larsen SD, Auerbach B, Bush MR, Lee C, Erasga N, Bowles DM, Boyles DC, Lu G, Sekerke C, Askew V, Hanselman JC, Dillon L, Lin Z, Robertson A, Olsen K, Boustany C, Atkinson K, Goosen TC, Sahasrabudhe V, Chupka J, Duignan DB, Feng B, Scialis R, Kimoto E, Bi YA, Lai Y, El-Kattan A, Bakker-Arkema R, Barclay P, Kindt E, Le V, Mandema JW, Milad M, Tait BD, Kennedy R, Trivedi BK, Kowala M
Source: Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2011 May 01; Vol. 21 (9), pp. 2725-31. Date of Electronic Publication: 2010 Nov 26.
Publication Type: Journal Article
Journal Info: Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 9107377 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3405 (Electronic) Linking ISSN: 0960894X NLM ISO Abbreviation: Bioorg Med Chem Lett Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 21183342
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Discovery of novel hepatoselective HMG-CoA reductase inhibitors for treating hypercholesterolemia: a bench-to-bedside case study on tissue selective drug distribution.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Pfefferkorn+JA%22">Pfefferkorn JA</searchLink>; Pfizer Global Research & Development, Eastern Point Road, Groton, CT 06340, USA. jeffrey.a.pfefferkorn@pfizer.com<br /><searchLink fieldCode="AU" term="%22Litchfield+J%22">Litchfield J</searchLink><br /><searchLink fieldCode="AU" term="%22Hutchings+R%22">Hutchings R</searchLink><br /><searchLink fieldCode="AU" term="%22Cheng+XM%22">Cheng XM</searchLink><br /><searchLink fieldCode="AU" term="%22Larsen+SD%22">Larsen SD</searchLink><br /><searchLink fieldCode="AU" term="%22Auerbach+B%22">Auerbach B</searchLink><br /><searchLink fieldCode="AU" term="%22Bush+MR%22">Bush MR</searchLink><br /><searchLink fieldCode="AU" term="%22Lee+C%22">Lee C</searchLink><br /><searchLink fieldCode="AU" term="%22Erasga+N%22">Erasga N</searchLink><br /><searchLink fieldCode="AU" term="%22Bowles+DM%22">Bowles DM</searchLink><br /><searchLink fieldCode="AU" term="%22Boyles+DC%22">Boyles DC</searchLink><br /><searchLink fieldCode="AU" term="%22Lu+G%22">Lu G</searchLink><br /><searchLink fieldCode="AU" term="%22Sekerke+C%22">Sekerke C</searchLink><br /><searchLink fieldCode="AU" term="%22Askew+V%22">Askew V</searchLink><br /><searchLink fieldCode="AU" term="%22Hanselman+JC%22">Hanselman JC</searchLink><br /><searchLink fieldCode="AU" term="%22Dillon+L%22">Dillon L</searchLink><br /><searchLink fieldCode="AU" term="%22Lin+Z%22">Lin Z</searchLink><br /><searchLink fieldCode="AU" term="%22Robertson+A%22">Robertson A</searchLink><br /><searchLink fieldCode="AU" term="%22Olsen+K%22">Olsen K</searchLink><br /><searchLink fieldCode="AU" term="%22Boustany+C%22">Boustany C</searchLink><br /><searchLink fieldCode="AU" term="%22Atkinson+K%22">Atkinson K</searchLink><br /><searchLink fieldCode="AU" term="%22Goosen+TC%22">Goosen TC</searchLink><br /><searchLink fieldCode="AU" term="%22Sahasrabudhe+V%22">Sahasrabudhe V</searchLink><br /><searchLink fieldCode="AU" term="%22Chupka+J%22">Chupka J</searchLink><br /><searchLink fieldCode="AU" term="%22Duignan+DB%22">Duignan DB</searchLink><br /><searchLink fieldCode="AU" term="%22Feng+B%22">Feng B</searchLink><br /><searchLink fieldCode="AU" term="%22Scialis+R%22">Scialis R</searchLink><br /><searchLink fieldCode="AU" term="%22Kimoto+E%22">Kimoto E</searchLink><br /><searchLink fieldCode="AU" term="%22Bi+YA%22">Bi YA</searchLink><br /><searchLink fieldCode="AU" term="%22Lai+Y%22">Lai Y</searchLink><br /><searchLink fieldCode="AU" term="%22El-Kattan+A%22">El-Kattan A</searchLink><br /><searchLink fieldCode="AU" term="%22Bakker-Arkema+R%22">Bakker-Arkema R</searchLink><br /><searchLink fieldCode="AU" term="%22Barclay+P%22">Barclay P</searchLink><br /><searchLink fieldCode="AU" term="%22Kindt+E%22">Kindt E</searchLink><br /><searchLink fieldCode="AU" term="%22Le+V%22">Le V</searchLink><br /><searchLink fieldCode="AU" term="%22Mandema+JW%22">Mandema JW</searchLink><br /><searchLink fieldCode="AU" term="%22Milad+M%22">Milad M</searchLink><br /><searchLink fieldCode="AU" term="%22Tait+BD%22">Tait BD</searchLink><br /><searchLink fieldCode="AU" term="%22Kennedy+R%22">Kennedy R</searchLink><br /><searchLink fieldCode="AU" term="%22Trivedi+BK%22">Trivedi BK</searchLink><br /><searchLink fieldCode="AU" term="%22Kowala+M%22">Kowala M</searchLink>
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%229107377%22">Bioorganic & medicinal chemistry letters</searchLink> [Bioorg Med Chem Lett] 2011 May 01; Vol. 21 (9), pp. 2725-31. <i>Date of Electronic Publication: </i>2010 Nov 26.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Elsevier+Science+Ltd%22">Elsevier Science Ltd </searchLink><i>Country of Publication: </i>England <i>NLM ID: </i>9107377 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1464-3405 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%220960894X%22">0960894X </searchLink><i>NLM ISO Abbreviation: </i>Bioorg Med Chem Lett <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=21183342
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1016/j.bmcl.2010.11.103
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 2725
    Titles:
      – TitleFull: Discovery of novel hepatoselective HMG-CoA reductase inhibitors for treating hypercholesterolemia: a bench-to-bedside case study on tissue selective drug distribution.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Pfefferkorn JA
      – PersonEntity:
          Name:
            NameFull: Litchfield J
      – PersonEntity:
          Name:
            NameFull: Hutchings R
      – PersonEntity:
          Name:
            NameFull: Cheng XM
      – PersonEntity:
          Name:
            NameFull: Larsen SD
      – PersonEntity:
          Name:
            NameFull: Auerbach B
      – PersonEntity:
          Name:
            NameFull: Bush MR
      – PersonEntity:
          Name:
            NameFull: Lee C
      – PersonEntity:
          Name:
            NameFull: Erasga N
      – PersonEntity:
          Name:
            NameFull: Bowles DM
      – PersonEntity:
          Name:
            NameFull: Boyles DC
      – PersonEntity:
          Name:
            NameFull: Lu G
      – PersonEntity:
          Name:
            NameFull: Sekerke C
      – PersonEntity:
          Name:
            NameFull: Askew V
      – PersonEntity:
          Name:
            NameFull: Hanselman JC
      – PersonEntity:
          Name:
            NameFull: Dillon L
      – PersonEntity:
          Name:
            NameFull: Lin Z
      – PersonEntity:
          Name:
            NameFull: Robertson A
      – PersonEntity:
          Name:
            NameFull: Olsen K
      – PersonEntity:
          Name:
            NameFull: Boustany C
      – PersonEntity:
          Name:
            NameFull: Atkinson K
      – PersonEntity:
          Name:
            NameFull: Goosen TC
      – PersonEntity:
          Name:
            NameFull: Sahasrabudhe V
      – PersonEntity:
          Name:
            NameFull: Chupka J
      – PersonEntity:
          Name:
            NameFull: Duignan DB
      – PersonEntity:
          Name:
            NameFull: Feng B
      – PersonEntity:
          Name:
            NameFull: Scialis R
      – PersonEntity:
          Name:
            NameFull: Kimoto E
      – PersonEntity:
          Name:
            NameFull: Bi YA
      – PersonEntity:
          Name:
            NameFull: Lai Y
      – PersonEntity:
          Name:
            NameFull: El-Kattan A
      – PersonEntity:
          Name:
            NameFull: Bakker-Arkema R
      – PersonEntity:
          Name:
            NameFull: Barclay P
      – PersonEntity:
          Name:
            NameFull: Kindt E
      – PersonEntity:
          Name:
            NameFull: Le V
      – PersonEntity:
          Name:
            NameFull: Mandema JW
      – PersonEntity:
          Name:
            NameFull: Milad M
      – PersonEntity:
          Name:
            NameFull: Tait BD
      – PersonEntity:
          Name:
            NameFull: Kennedy R
      – PersonEntity:
          Name:
            NameFull: Trivedi BK
      – PersonEntity:
          Name:
            NameFull: Kowala M
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 05
              Text: 2011 May 01
              Type: published
              Y: 2011
          Identifiers:
            – Type: issn-electronic
              Value: 1464-3405
          Numbering:
            – Type: volume
              Value: 21
            – Type: issue
              Value: 9
          Titles:
            – TitleFull: Bioorganic & medicinal chemistry letters
              Type: main
ResultId 1