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Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3.

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Title: Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3.
Authors: Disch JS; Sirtris a GSK Company, Cambridge, Massachusetts, United States. jdisch92@gmail.com, Evindar G, Chiu CH, Blum CA, Dai H, Jin L, Schuman E, Lind KE, Belyanskaya SL, Deng J, Coppo F, Aquilani L, Graybill TL, Cuozzo JW, Lavu S, Mao C, Vlasuk GP, Perni RB
Source: Journal of medicinal chemistry [J Med Chem] 2013 May 09; Vol. 56 (9), pp. 3666-79. Date of Electronic Publication: 2013 Apr 29.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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PubType: Academic Journal
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  Data: Discovery of thieno[3,2-d]pyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3.
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  Data: <searchLink fieldCode="AU" term="%22Disch+JS%22">Disch JS</searchLink>; Sirtris a GSK Company, Cambridge, Massachusetts, United States. jdisch92@gmail.com<br /><searchLink fieldCode="AU" term="%22Evindar+G%22">Evindar G</searchLink><br /><searchLink fieldCode="AU" term="%22Chiu+CH%22">Chiu CH</searchLink><br /><searchLink fieldCode="AU" term="%22Blum+CA%22">Blum CA</searchLink><br /><searchLink fieldCode="AU" term="%22Dai+H%22">Dai H</searchLink><br /><searchLink fieldCode="AU" term="%22Jin+L%22">Jin L</searchLink><br /><searchLink fieldCode="AU" term="%22Schuman+E%22">Schuman E</searchLink><br /><searchLink fieldCode="AU" term="%22Lind+KE%22">Lind KE</searchLink><br /><searchLink fieldCode="AU" term="%22Belyanskaya+SL%22">Belyanskaya SL</searchLink><br /><searchLink fieldCode="AU" term="%22Deng+J%22">Deng J</searchLink><br /><searchLink fieldCode="AU" term="%22Coppo+F%22">Coppo F</searchLink><br /><searchLink fieldCode="AU" term="%22Aquilani+L%22">Aquilani L</searchLink><br /><searchLink fieldCode="AU" term="%22Graybill+TL%22">Graybill TL</searchLink><br /><searchLink fieldCode="AU" term="%22Cuozzo+JW%22">Cuozzo JW</searchLink><br /><searchLink fieldCode="AU" term="%22Lavu+S%22">Lavu S</searchLink><br /><searchLink fieldCode="AU" term="%22Mao+C%22">Mao C</searchLink><br /><searchLink fieldCode="AU" term="%22Vlasuk+GP%22">Vlasuk GP</searchLink><br /><searchLink fieldCode="AU" term="%22Perni+RB%22">Perni RB</searchLink>
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  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2013 May 09; Vol. 56 (9), pp. 3666-79. <i>Date of Electronic Publication: </i>2013 Apr 29.
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=23570514
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        Value: 10.1021/jm400204k
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      – Code: eng
        Text: English
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        StartPage: 3666
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            – D: 09
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              Text: 2013 May 09
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              Y: 2013
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              Value: 56
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              Value: 9
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