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The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.

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Title: The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Authors: Yun MK; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Hoagland D; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Kumar G; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Waddell MB; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA., Rock CO; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38163, USA., Lee RE; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38163, USA. Electronic address: richard.lee@stjude.org., White SW; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38163, USA. Electronic address: stephen.white@stjude.org.
Source: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2014 Apr 01; Vol. 22 (7), pp. 2157-65. Date of Electronic Publication: 2014 Feb 25.
Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
Journal Info: Publisher: Elsevier Science Country of Publication: England NLM ID: 9413298 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1464-3391 (Electronic) Linking ISSN: 09680896 NLM ISO Abbreviation: Bioorg Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
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  Data: <searchLink fieldCode="AU" term="%22Yun+MK%22">Yun MK</searchLink>; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.<br /><searchLink fieldCode="AU" term="%22Hoagland+D%22">Hoagland D</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.<br /><searchLink fieldCode="AU" term="%22Kumar+G%22">Kumar G</searchLink>; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.<br /><searchLink fieldCode="AU" term="%22Waddell+MB%22">Waddell MB</searchLink>; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.<br /><searchLink fieldCode="AU" term="%22Rock+CO%22">Rock CO</searchLink>; Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38163, USA.<br /><searchLink fieldCode="AU" term="%22Lee+RE%22">Lee RE</searchLink>; Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38163, USA. Electronic address: richard.lee@stjude.org.<br /><searchLink fieldCode="AU" term="%22White+SW%22">White SW</searchLink>; Department of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Microbiology, Immunology and Biochemistry, University of Tennessee Health Science Center, Memphis, TN 38163, USA. Electronic address: stephen.white@stjude.org.
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              Text: 2014 Apr 01
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