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The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor.

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Title: The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor.
Authors: Duffy JP; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States., Harrington EM; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States., Salituro FG; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States., Cochran JE; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States., Green J; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States., Gao H; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States., Bemis GW; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States., Evindar G; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States., Galullo VP; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States., Ford PJ; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States., Germann UA; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States., Wilson KP; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States., Bellon SF; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States., Chen G; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States., Taslimi P; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States., Jones P; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States., Huang C; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States., Pazhanisamy S; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States., Wang YM; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States., Murcko MA; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States., Su MS; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States.
Source: ACS medicinal chemistry letters [ACS Med Chem Lett] 2011 Jul 28; Vol. 2 (10), pp. 758-63. Date of Electronic Publication: 2011 Jul 28 (Print Publication: 2011).
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101521073 Publication Model: eCollection Cited Medium: Print ISSN: 1948-5875 (Print) Linking ISSN: 19485875 NLM ISO Abbreviation: ACS Med Chem Lett Subsets: PubMed not MEDLINE
Database: MEDLINE Ultimate
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  Data: <searchLink fieldCode="AU" term="%22Duffy+JP%22">Duffy JP</searchLink>; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States.<br /><searchLink fieldCode="AU" term="%22Harrington+EM%22">Harrington EM</searchLink>; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States.<br /><searchLink fieldCode="AU" term="%22Salituro+FG%22">Salituro FG</searchLink>; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States.<br /><searchLink fieldCode="AU" term="%22Cochran+JE%22">Cochran JE</searchLink>; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States.<br /><searchLink fieldCode="AU" term="%22Green+J%22">Green J</searchLink>; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States.<br /><searchLink fieldCode="AU" term="%22Gao+H%22">Gao H</searchLink>; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States.<br /><searchLink fieldCode="AU" term="%22Bemis+GW%22">Bemis GW</searchLink>; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States.<br /><searchLink fieldCode="AU" term="%22Evindar+G%22">Evindar G</searchLink>; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States.<br /><searchLink fieldCode="AU" term="%22Galullo+VP%22">Galullo VP</searchLink>; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States.<br /><searchLink fieldCode="AU" term="%22Ford+PJ%22">Ford PJ</searchLink>; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States.<br /><searchLink fieldCode="AU" term="%22Germann+UA%22">Germann UA</searchLink>; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States.<br /><searchLink fieldCode="AU" term="%22Wilson+KP%22">Wilson KP</searchLink>; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States.<br /><searchLink fieldCode="AU" term="%22Bellon+SF%22">Bellon SF</searchLink>; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States.<br /><searchLink fieldCode="AU" term="%22Chen+G%22">Chen G</searchLink>; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States.<br /><searchLink fieldCode="AU" term="%22Taslimi+P%22">Taslimi P</searchLink>; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States.<br /><searchLink fieldCode="AU" term="%22Jones+P%22">Jones P</searchLink>; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States.<br /><searchLink fieldCode="AU" term="%22Huang+C%22">Huang C</searchLink>; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States.<br /><searchLink fieldCode="AU" term="%22Pazhanisamy+S%22">Pazhanisamy S</searchLink>; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States.<br /><searchLink fieldCode="AU" term="%22Wang+YM%22">Wang YM</searchLink>; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States.<br /><searchLink fieldCode="AU" term="%22Murcko+MA%22">Murcko MA</searchLink>; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States.<br /><searchLink fieldCode="AU" term="%22Su+MS%22">Su MS</searchLink>; Vertex Pharmaceuticals , 130 Waverly Street, Cambridge, Massachusetts 02139-4242, United States.
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  Data: <searchLink fieldCode="JN" term="%22101521073%22">ACS medicinal chemistry letters</searchLink> [ACS Med Chem Lett] 2011 Jul 28; Vol. 2 (10), pp. 758-63. <i>Date of Electronic Publication: </i>2011 Jul 28 (<i>Print Publication: </i>2011).
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