Transcriptional diversity during lineage commitment of human blood progenitors.
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| Title: | Transcriptional diversity during lineage commitment of human blood progenitors. |
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| Authors: | Chen L; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom., Kostadima M; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom., Martens JHA; Department of Molecular Biology, Radboud University, Nijmegen, the Netherlands., Canu G; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom., Garcia SP; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom., Turro E; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom., Downes K; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom., Macaulay IC; Sanger Institute-EBI Single-Cell Genomics Centre, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom., Bielczyk-Maczynska E; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom., Coe S; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom., Farrow S; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom., Poudel P; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom., Burden F; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom., Jansen SBG; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom., Astle WJ; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Medical Research Council Biostatistics Unit, Cambridge Biomedical Campus, Cambridge, United Kingdom., Attwood A; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom., Bariana T; Department of Haematology, University College London Cancer Institute, London, United Kingdom.; The Katharine Dormandy Haemophilia Centre and Thrombosis Unit, Royal Free NHS Trust, London, United Kingdom., de Bono B; CHIME Institute, University College London, Archway Campus, London, United Kingdom.; Auckland Bioengineering Institute, University of Auckland, New Zealand., Breschi A; Centre for Genomic Regulation and University Pompeu Fabra, Barcelona, Spain., Chambers JC; Imperial College Healthcare NHS Trust, DuCane Road, London, United Kingdom.; Ealing Hospital NHS Trust, Southall, Middlesex, United Kingdom., Consortium B; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom., Choudry FA; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom., Clarke L; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom., Coupland P; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom., van der Ent M; Department of Molecular Biology, Radboud University, Nijmegen, the Netherlands., Erber WN; Pathology and Laboratory Medicine, University of Western Australia, Crawley, Western Australia, Australia., Jansen JH; Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Nijmegen, the Netherlands., Favier R; Assistance Publique-Hopitaux de Paris, Institut National de la Santé et de la Recherche Médicale U1009, Villejuif, France., Fenech ME; Biomedical Research Centre, Norwich Medical School, University of East Anglia, Norwich, United Kingdom., Foad N; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom., Freson K; Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium., van Geet C; Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium., Gomez K; The Katharine Dormandy Haemophilia Centre and Thrombosis Unit, Royal Free NHS Trust, London, United Kingdom., Guigo R; Centre for Genomic Regulation and University Pompeu Fabra, Barcelona, Spain., Hampshire D; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom., Kelly AM; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge, United Kingdom., Kerstens HHD; Department of Molecular Biology, Radboud University, Nijmegen, the Netherlands., Kooner JS; Imperial College Healthcare NHS Trust, DuCane Road, London, United Kingdom.; Ealing Hospital NHS Trust, Southall, Middlesex, United Kingdom., Laffan M; Department of Haematology, Hammersmith Campus, Imperial College Academic Health Sciences Centre, Imperial College London, London, United Kingdom., Lentaigne C; Department of Haematology, Hammersmith Campus, Imperial College Academic Health Sciences Centre, Imperial College London, London, United Kingdom., Labalette C; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom., Martin T; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Department of Twin Research & Genetic Epidemiology, Genetics & Molecular Medicine Division, St Thomas' Hospital, King's College, London, United Kingdom., Meacham S; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom., Mumford A; School of Cellular and Molecular Medicine, University of Bristol, Bristol, United Kingdom., Nürnberg S; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom., Palumbo E; Centre for Genomic Regulation and University Pompeu Fabra, Barcelona, Spain., van der Reijden BA; Department of Laboratory Medicine, Laboratory of Hematology, Radboud University Medical Center, Nijmegen, the Netherlands., Richardson D; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom., Sammut SJ; Department of Oncology, Addenbrooke's Cambridge University Hospital NHS Trust, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Cancer Research United Kingdom, Cambridge Institute, Cambridge Biomedical Campus, Cambridge, United Kingdom., Slodkowicz G; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom., Tamuri AU; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom., Vasquez L; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom., Voss K; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom., Watt S; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom., Westbury S; School of Clinical Sciences, University of Bristol, United Kingdom., Flicek P; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom., Loos R; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom., Goldman N; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom., Bertone P; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom.; Genome Biology and Developmental Biology Units, European Molecular Biology Laboratory, Heidelberg, Germany.; Wellcome Trust - Medical Research Council Stem Cell Institute, University of Cambridge, Cambridge, United Kingdom., Read RJ; Department of Haematology, Cambridge Institute for Medical Research, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom., Richardson S; Medical Research Council Biostatistics Unit, Cambridge Biomedical Campus, Cambridge, United Kingdom., Cvejic A; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom., Soranzo N; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom.; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom., Ouwehand WH; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, United Kingdom., Stunnenberg HG; Department of Molecular Biology, Radboud University, Nijmegen, the Netherlands., Frontini M; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom., Rendon A; Department of Haematology, University of Cambridge, Cambridge Biomedical Campus, Cambridge, United Kingdom.; NHS Blood and Transplant, Cambridge Biomedical Campus, Cambridge, United Kingdom.; Medical Research Council Biostatistics Unit, Cambridge Biomedical Campus, Cambridge, United Kingdom. |
| Source: | Science (New York, N.Y.) [Science] 2014 Sep 26; Vol. 345 (6204), pp. 1251033. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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