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Factors influencing success of clinical genome sequencing across a broad spectrum of disorders.

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Title: Factors influencing success of clinical genome sequencing across a broad spectrum of disorders.
Authors: Taylor JC; NIHR Comprehensive Biomedical Research Centre, Oxford, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Martin HC; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Lise S; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Broxholme J; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Cazier JB; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Rimmer A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Kanapin A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Lunter G; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Fiddy S; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Allan C; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Aricescu AR; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Attar M; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Babbs C; MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Becq J; Illumina Cambridge Limited, Saffron Walden, UK., Beeson D; Neurosciences Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Bento C; Hematology Department, Centro Hospitalar e Universitário de Coimbra, Portugal., Bignell P; Molecular Haematology Department, Oxford University Hospitals NHS Trust, Oxford, UK., Blair E; Department of Clinical Genetics, Oxford University Hospitals NHS Trust, Oxford, UK., Buckle VJ; MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Bull K; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Centre for Cellular and Molecular Physiology, University of Oxford, Oxford, UK., Cais O; Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK., Cario H; Department of Pediatrics and Adolescent Medicine, University Medical Center, Ulm, Germany., Chapel H; Primary Immunodeficiency Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Copley RR; NIHR Comprehensive Biomedical Research Centre, Oxford, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Cornall R; Centre for Cellular and Molecular Physiology, University of Oxford, Oxford, UK., Craft J; NIHR Comprehensive Biomedical Research Centre, Oxford, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Dahan K; Centre de Génétique Humaine, Institut de Génétique et de Pathologie, Gosselies, Belgium.; Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Brussels, Belgium., Davenport EE; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Dendrou C; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Devuyst O; Institute of Physiology, Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland., Fenwick AL; Clinical Genetics Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Flint J; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Fugger L; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Gilbert RD; University Hospital Southampton NHS Foundation Trust, University of Southampton, Southampton, UK., Goriely A; Clinical Genetics Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Green A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Greger IH; Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, UK., Grocock R; Illumina Cambridge Limited, Saffron Walden, UK., Gruszczyk AV; Clinical Genetics Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Hastings R; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Hatton E; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Higgs D; MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Hill A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; The Jenner Institute, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Holmes C; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Department of Statistics, University of Oxford, Oxford, UK., Howard M; NIHR Comprehensive Biomedical Research Centre, Oxford, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Hughes L; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Humburg P; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Johnson D; Craniofacial Unit, Department of Plastic and Reconstructive Surgery, Oxford University Hospitals NHS Trust, Oxford, UK., Karpe F; Oxford Laboratory for Integrative Physiology, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK., Kingsbury Z; Illumina Cambridge Limited, Saffron Walden, UK., Kini U; Department of Clinical Genetics, Oxford University Hospitals NHS Trust, Oxford, UK., Knight JC; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Krohn J; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Lamble S; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Langman C; Kidney Diseases, Feinberg School of Medicine, Northwestern University and the Ann and Robert H Lurie Children's Hospital of Chicago, Chicago, Illinois, USA., Lonie L; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Luck J; Clinical Genetics Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., McCarthy D; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., McGowan SJ; Clinical Genetics Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., McMullin MF; Centre for Cancer Research and Cell Biology, Queen's University, Belfast, UK., Miller KA; Clinical Genetics Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Murray L; Illumina Cambridge Limited, Saffron Walden, UK., Németh AH; Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK., Nesbit MA; Academic Endocrine Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK., Nutt D; Centre for Neuropsychopharmacology, Division of Brain Sciences, Imperial College, London, UK., Ormondroyd E; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Oturai AB; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Copenhagen, Denmark., Pagnamenta A; NIHR Comprehensive Biomedical Research Centre, Oxford, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Patel SY; Primary Immunodeficiency Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Percy M; Department of Haematology, Belfast City Hospital, Belfast, UK., Petousi N; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Piazza P; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Piret SE; Academic Endocrine Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK., Polanco-Echeverry G; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Popitsch N; NIHR Comprehensive Biomedical Research Centre, Oxford, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Powrie F; Translational Gastroenterology Unit, University of Oxford, Oxford, UK., Pugh C; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Quek L; MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Robbins PA; Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK., Robson K; MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Russo A; Department of Pediatrics, University Hospital, Mainz, Germany., Sahgal N; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., van Schouwenburg PA; Primary Immunodeficiency Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Schuh A; NIHR Comprehensive Biomedical Research Centre, Oxford, UK.; Department of Oncology, University of Oxford, Oxford, UK., Silverman E; Division of Rheumatology, The Hospital for Sick Children, Toronto, Ontario, Canada., Simmons A; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.; Translational Gastroenterology Unit, University of Oxford, Oxford, UK., Sørensen PS; Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital, Copenhagen, Denmark., Sweeney E; Department of Clinical Genetics, Liverpool Women's NHS Foundation Trust, Liverpool, UK., Taylor J; NIHR Comprehensive Biomedical Research Centre, Oxford, UK.; Oxford NHS Regional Molecular Genetics Laboratory, Oxford University Hospitals NHS Trust, Oxford, UK., Thakker RV; Academic Endocrine Unit, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Churchill Hospital, Oxford, UK., Tomlinson I; NIHR Comprehensive Biomedical Research Centre, Oxford, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Trebes A; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Twigg SR; Clinical Genetics Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Uhlig HH; Translational Gastroenterology Unit, University of Oxford, Oxford, UK., Vyas P; MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Vyse T; Division of Genetics, King's College London, Guy's Hospital, London, UK., Wall SA; Craniofacial Unit, Department of Plastic and Reconstructive Surgery, Oxford University Hospitals NHS Trust, Oxford, UK., Watkins H; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK., Whyte MP; Center for Metabolic Bone Disease and Molecular Research, Shriners Hospital for Children, St Louis, Missouri, USA., Witty L; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Wright B; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Yau C; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Buck D; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK., Humphray S; Illumina Cambridge Limited, Saffron Walden, UK., Ratcliffe PJ; Nuffield Department of Medicine, University of Oxford, Oxford, UK., Bell JI; Office of the Regius Professor of Medicine, University of Oxford, Oxford, UK., Wilkie AO; Clinical Genetics Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK., Bentley D; Illumina Cambridge Limited, Saffron Walden, UK., Donnelly P; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Department of Statistics, University of Oxford, Oxford, UK., McVean G; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Source: Nature genetics [Nat Genet] 2015 Jul; Vol. 47 (7), pp. 717-726. Date of Electronic Publication: 2015 May 18.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Nature Pub. Co Country of Publication: United States NLM ID: 9216904 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1546-1718 (Electronic) Linking ISSN: 10614036 NLM ISO Abbreviation: Nat Genet Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Factors influencing success of clinical genome sequencing across a broad spectrum of disorders.
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NIHR Comprehensive Biomedical Research Centre, Oxford, UK.; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Trebes+A%22">Trebes A</searchLink>; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Twigg+SR%22">Twigg SR</searchLink>; Clinical Genetics Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Uhlig+HH%22">Uhlig HH</searchLink>; Translational Gastroenterology Unit, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Vyas+P%22">Vyas P</searchLink>; MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Vyse+T%22">Vyse T</searchLink>; Division of Genetics, King's College London, Guy's Hospital, London, UK.<br /><searchLink fieldCode="AU" term="%22Wall+SA%22">Wall SA</searchLink>; Craniofacial Unit, Department of Plastic and Reconstructive Surgery, Oxford University Hospitals NHS Trust, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Watkins+H%22">Watkins H</searchLink>; Division of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Whyte+MP%22">Whyte MP</searchLink>; Center for Metabolic Bone Disease and Molecular Research, Shriners Hospital for Children, St Louis, Missouri, USA.<br /><searchLink fieldCode="AU" term="%22Witty+L%22">Witty L</searchLink>; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Wright+B%22">Wright B</searchLink>; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Yau+C%22">Yau C</searchLink>; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Buck+D%22">Buck D</searchLink>; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Humphray+S%22">Humphray S</searchLink>; Illumina Cambridge Limited, Saffron Walden, UK.<br /><searchLink fieldCode="AU" term="%22Ratcliffe+PJ%22">Ratcliffe PJ</searchLink>; Nuffield Department of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Bell+JI%22">Bell JI</searchLink>; Office of the Regius Professor of Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Wilkie+AO%22">Wilkie AO</searchLink>; Clinical Genetics Group, Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22Bentley+D%22">Bentley D</searchLink>; Illumina Cambridge Limited, Saffron Walden, UK.<br /><searchLink fieldCode="AU" term="%22Donnelly+P%22">Donnelly P</searchLink>; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.; Department of Statistics, University of Oxford, Oxford, UK.<br /><searchLink fieldCode="AU" term="%22McVean+G%22">McVean G</searchLink>; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
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  Data: <searchLink fieldCode="JN" term="%229216904%22">Nature genetics</searchLink> [Nat Genet] 2015 Jul; Vol. 47 (7), pp. 717-726. <i>Date of Electronic Publication: </i>2015 May 18.
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  Data: Journal Article; Research Support, Non-U.S. Gov't
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  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22Nature+Pub%2E+Co%22">Nature Pub. Co </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9216904 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1546-1718 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2210614036%22">10614036 </searchLink><i>NLM ISO Abbreviation: </i>Nat Genet <i>Subsets: </i>MEDLINE
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