View in EDS PDF Full Text

Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response.

Saved in:
Bibliographic Details
Title: Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response.
Authors: Sun Y; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA., Peng I; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA., Webster JD; Department of Pathology, Genentech Inc., South San Francisco, CA 94080, USA., Suto E; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA., Lesch J; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA., Wu X; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA., Senger K; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA., Francis G; Department of Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, CA 94080, USA., Barrett K; Department of Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, CA 94080, USA., Collier JL; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA., Burch JD; Department of Discovery Chemistry, Genentech Inc., South San Francisco, CA 94080, USA., Zhou M; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA., Chen Y; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, CA 94080, USA., Chan C; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, CA 94080, USA., Eastham-Anderson J; Department of Pathology, Genentech Inc., South San Francisco, CA 94080, USA., Ngu H; Department of Pathology, Genentech Inc., South San Francisco, CA 94080, USA., Li O; Department of Biomarker Development, Genentech Inc., South San Francisco, CA 94080, USA., Staton T; Department of Biomarker Development, Genentech Inc., South San Francisco, CA 94080, USA., Havnar C; Department of Pathology, Genentech Inc., South San Francisco, CA 94080, USA., Jaochico A; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, CA 94080, USA., Jackman J; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA., Jeet S; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA., Riol-Blanco L; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA., Wu LC; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA., Choy DF; Department of Immunology, Tissue Growth, and Repair Diagnostics Discovery, Genentech Inc., South San Francisco, CA 94080, USA., Arron JR; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA., McKenzie BS; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA., Ghilardi N; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA., Ismaili MH; Department of Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, CA 94080, USA., Pei Z; Department of Discovery Chemistry, Genentech Inc., South San Francisco, CA 94080, USA., DeVoss J; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA., Austin CD; Department of Pathology, Genentech Inc., South San Francisco, CA 94080, USA., Lee WP; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA., Zarrin AA; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA. zarrin.ali@gene.com.
Source: Science signaling [Sci Signal] 2015 Dec 01; Vol. 8 (405), pp. ra122. Date of Electronic Publication: 2015 Dec 01.
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
Journal Info: Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Links:
  – Type: pdflink
Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 26628680
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Sun+Y%22">Sun Y</searchLink>; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Peng+I%22">Peng I</searchLink>; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Webster+JD%22">Webster JD</searchLink>; Department of Pathology, Genentech Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Suto+E%22">Suto E</searchLink>; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Lesch+J%22">Lesch J</searchLink>; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Wu+X%22">Wu X</searchLink>; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Senger+K%22">Senger K</searchLink>; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Francis+G%22">Francis G</searchLink>; Department of Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Barrett+K%22">Barrett K</searchLink>; Department of Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Collier+JL%22">Collier JL</searchLink>; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Burch+JD%22">Burch JD</searchLink>; Department of Discovery Chemistry, Genentech Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Zhou+M%22">Zhou M</searchLink>; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Chen+Y%22">Chen Y</searchLink>; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Chan+C%22">Chan C</searchLink>; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Eastham-Anderson+J%22">Eastham-Anderson J</searchLink>; Department of Pathology, Genentech Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Ngu+H%22">Ngu H</searchLink>; Department of Pathology, Genentech Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Li+O%22">Li O</searchLink>; Department of Biomarker Development, Genentech Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Staton+T%22">Staton T</searchLink>; Department of Biomarker Development, Genentech Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Havnar+C%22">Havnar C</searchLink>; Department of Pathology, Genentech Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Jaochico+A%22">Jaochico A</searchLink>; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Jackman+J%22">Jackman J</searchLink>; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Jeet+S%22">Jeet S</searchLink>; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Riol-Blanco+L%22">Riol-Blanco L</searchLink>; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Wu+LC%22">Wu LC</searchLink>; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Choy+DF%22">Choy DF</searchLink>; Department of Immunology, Tissue Growth, and Repair Diagnostics Discovery, Genentech Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Arron+JR%22">Arron JR</searchLink>; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22McKenzie+BS%22">McKenzie BS</searchLink>; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Ghilardi+N%22">Ghilardi N</searchLink>; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Ismaili+MH%22">Ismaili MH</searchLink>; Department of Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Pei+Z%22">Pei Z</searchLink>; Department of Discovery Chemistry, Genentech Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22DeVoss+J%22">DeVoss J</searchLink>; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Austin+CD%22">Austin CD</searchLink>; Department of Pathology, Genentech Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Lee+WP%22">Lee WP</searchLink>; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA.<br /><searchLink fieldCode="AU" term="%22Zarrin+AA%22">Zarrin AA</searchLink>; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA. zarrin.ali@gene.com.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%22101465400%22">Science signaling</searchLink> [Sci Signal] 2015 Dec 01; Vol. 8 (405), pp. ra122. <i>Date of Electronic Publication: </i>2015 Dec 01.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article; Research Support, Non-U.S. Gov't
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Association+for+the+Advancement+of+Science%22">American Association for the Advancement of Science </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>101465400 <i>Publication Model: </i>Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1937-9145 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2219450877%22">19450877 </searchLink><i>NLM ISO Abbreviation: </i>Sci Signal <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=26628680
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1126/scisignal.aab0949
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: ra122
    Titles:
      – TitleFull: Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Sun Y
      – PersonEntity:
          Name:
            NameFull: Peng I
      – PersonEntity:
          Name:
            NameFull: Webster JD
      – PersonEntity:
          Name:
            NameFull: Suto E
      – PersonEntity:
          Name:
            NameFull: Lesch J
      – PersonEntity:
          Name:
            NameFull: Wu X
      – PersonEntity:
          Name:
            NameFull: Senger K
      – PersonEntity:
          Name:
            NameFull: Francis G
      – PersonEntity:
          Name:
            NameFull: Barrett K
      – PersonEntity:
          Name:
            NameFull: Collier JL
      – PersonEntity:
          Name:
            NameFull: Burch JD
      – PersonEntity:
          Name:
            NameFull: Zhou M
      – PersonEntity:
          Name:
            NameFull: Chen Y
      – PersonEntity:
          Name:
            NameFull: Chan C
      – PersonEntity:
          Name:
            NameFull: Eastham-Anderson J
      – PersonEntity:
          Name:
            NameFull: Ngu H
      – PersonEntity:
          Name:
            NameFull: Li O
      – PersonEntity:
          Name:
            NameFull: Staton T
      – PersonEntity:
          Name:
            NameFull: Havnar C
      – PersonEntity:
          Name:
            NameFull: Jaochico A
      – PersonEntity:
          Name:
            NameFull: Jackman J
      – PersonEntity:
          Name:
            NameFull: Jeet S
      – PersonEntity:
          Name:
            NameFull: Riol-Blanco L
      – PersonEntity:
          Name:
            NameFull: Wu LC
      – PersonEntity:
          Name:
            NameFull: Choy DF
      – PersonEntity:
          Name:
            NameFull: Arron JR
      – PersonEntity:
          Name:
            NameFull: McKenzie BS
      – PersonEntity:
          Name:
            NameFull: Ghilardi N
      – PersonEntity:
          Name:
            NameFull: Ismaili MH
      – PersonEntity:
          Name:
            NameFull: Pei Z
      – PersonEntity:
          Name:
            NameFull: DeVoss J
      – PersonEntity:
          Name:
            NameFull: Austin CD
      – PersonEntity:
          Name:
            NameFull: Lee WP
      – PersonEntity:
          Name:
            NameFull: Zarrin AA
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 01
              M: 12
              Text: 2015 Dec 01
              Type: published
              Y: 2015
          Identifiers:
            – Type: issn-electronic
              Value: 1937-9145
          Numbering:
            – Type: volume
              Value: 8
            – Type: issue
              Value: 405
          Titles:
            – TitleFull: Science signaling
              Type: main
ResultId 1