Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response.
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| Title: | Inhibition of the kinase ITK in a mouse model of asthma reduces cell death and fails to inhibit the inflammatory response. |
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| Authors: | Sun Y; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA., Peng I; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA., Webster JD; Department of Pathology, Genentech Inc., South San Francisco, CA 94080, USA., Suto E; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA., Lesch J; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA., Wu X; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA., Senger K; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA., Francis G; Department of Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, CA 94080, USA., Barrett K; Department of Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, CA 94080, USA., Collier JL; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA., Burch JD; Department of Discovery Chemistry, Genentech Inc., South San Francisco, CA 94080, USA., Zhou M; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA., Chen Y; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, CA 94080, USA., Chan C; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, CA 94080, USA., Eastham-Anderson J; Department of Pathology, Genentech Inc., South San Francisco, CA 94080, USA., Ngu H; Department of Pathology, Genentech Inc., South San Francisco, CA 94080, USA., Li O; Department of Biomarker Development, Genentech Inc., South San Francisco, CA 94080, USA., Staton T; Department of Biomarker Development, Genentech Inc., South San Francisco, CA 94080, USA., Havnar C; Department of Pathology, Genentech Inc., South San Francisco, CA 94080, USA., Jaochico A; Department of Drug Metabolism and Pharmacokinetics, Genentech Inc., South San Francisco, CA 94080, USA., Jackman J; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA., Jeet S; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA., Riol-Blanco L; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA., Wu LC; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA., Choy DF; Department of Immunology, Tissue Growth, and Repair Diagnostics Discovery, Genentech Inc., South San Francisco, CA 94080, USA., Arron JR; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA., McKenzie BS; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA., Ghilardi N; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA., Ismaili MH; Department of Biochemical and Cellular Pharmacology, Genentech Inc., South San Francisco, CA 94080, USA., Pei Z; Department of Discovery Chemistry, Genentech Inc., South San Francisco, CA 94080, USA., DeVoss J; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA., Austin CD; Department of Pathology, Genentech Inc., South San Francisco, CA 94080, USA., Lee WP; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA., Zarrin AA; Department of Immunology, Genentech Inc., South San Francisco, CA 94080, USA. zarrin.ali@gene.com. |
| Source: | Science signaling [Sci Signal] 2015 Dec 01; Vol. 8 (405), pp. ra122. Date of Electronic Publication: 2015 Dec 01. |
| Publication Type: | Journal Article; Research Support, Non-U.S. Gov't |
| Journal Info: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 101465400 Publication Model: Electronic Cited Medium: Internet ISSN: 1937-9145 (Electronic) Linking ISSN: 19450877 NLM ISO Abbreviation: Sci Signal Subsets: MEDLINE |
| Database: | MEDLINE Ultimate |
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