View in EDS

Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives.

Saved in:
Bibliographic Details
Title: Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives.
Authors: Westaway SM; Epinova Discovery Performance Unit, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K., Preston AG; Epinova Discovery Performance Unit, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K., Barker MD; Epinova Discovery Performance Unit, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K., Brown F; Platform Technology and Sciences, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K., Brown JA; Epinova Discovery Performance Unit, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K., Campbell M; Epinova Discovery Performance Unit, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K., Chung CW; Platform Technology and Sciences, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K., Drewes G; Cellzome GmbH, a GSK Company , Meyerhofstrasse 1, 69117 Heidelberg, Germany., Eagle R; Platform Technology and Sciences, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K., Garton N; Epinova Discovery Performance Unit, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K., Gordon L; Platform Technology and Sciences, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K., Haslam C; Platform Technology and Sciences, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K., Hayhow TG; Epinova Discovery Performance Unit, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K., Humphreys PG; Epinova Discovery Performance Unit, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K., Joberty G; Cellzome GmbH, a GSK Company , Meyerhofstrasse 1, 69117 Heidelberg, Germany., Katso R; Platform Technology and Sciences, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K., Kruidenier L; Epinova Discovery Performance Unit, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K., Leveridge M; Platform Technology and Sciences, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K., Pemberton M; Platform Technology and Sciences, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K., Rioja I; Epinova Discovery Performance Unit, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K., Seal GA; Epinova Discovery Performance Unit, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K., Shipley T; Epinova Discovery Performance Unit, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K., Singh O; Platform Technology and Sciences, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K., Suckling CJ; Department of Pure and Applied Chemistry, WestCHEM Research School, University of Strathclyde , Glasgow G1 1XL, U.K., Taylor J; Platform Technology and Sciences, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K., Thomas P; Platform Technology and Sciences, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K., Wilson DM; Epinova Discovery Performance Unit, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K., Lee K; Epinova Discovery Performance Unit, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K., Prinjha RK; Epinova Discovery Performance Unit, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K.
Source: Journal of medicinal chemistry [J Med Chem] 2016 Feb 25; Vol. 59 (4), pp. 1370-87. Date of Electronic Publication: 2016 Jan 15.
Publication Type: Journal Article
Journal Info: Publisher: American Chemical Society Country of Publication: United States NLM ID: 9716531 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-4804 (Electronic) Linking ISSN: 00222623 NLM ISO Abbreviation: J Med Chem Subsets: MEDLINE
Database: MEDLINE Ultimate
FullText Text:
  Availability: 0
Header DbId: mdl
DbLabel: MEDLINE Ultimate
An: 26771203
AccessLevel: 2
PubType: Academic Journal
PubTypeId: academicJournal
PreciseRelevancyScore: 0
IllustrationInfo
Items – Name: Title
  Label: Title
  Group: Ti
  Data: Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives.
– Name: Author
  Label: Authors
  Group: Au
  Data: <searchLink fieldCode="AU" term="%22Westaway+SM%22">Westaway SM</searchLink>; Epinova Discovery Performance Unit, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K.<br /><searchLink fieldCode="AU" term="%22Preston+AG%22">Preston AG</searchLink>; Epinova Discovery Performance Unit, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K.<br /><searchLink fieldCode="AU" term="%22Barker+MD%22">Barker MD</searchLink>; Epinova Discovery Performance Unit, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K.<br /><searchLink fieldCode="AU" term="%22Brown+F%22">Brown F</searchLink>; Platform Technology and Sciences, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K.<br /><searchLink fieldCode="AU" term="%22Brown+JA%22">Brown JA</searchLink>; Epinova Discovery Performance Unit, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K.<br /><searchLink fieldCode="AU" term="%22Campbell+M%22">Campbell M</searchLink>; Epinova Discovery Performance Unit, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K.<br /><searchLink fieldCode="AU" term="%22Chung+CW%22">Chung CW</searchLink>; Platform Technology and Sciences, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K.<br /><searchLink fieldCode="AU" term="%22Drewes+G%22">Drewes G</searchLink>; Cellzome GmbH, a GSK Company , Meyerhofstrasse 1, 69117 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Eagle+R%22">Eagle R</searchLink>; Platform Technology and Sciences, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K.<br /><searchLink fieldCode="AU" term="%22Garton+N%22">Garton N</searchLink>; Epinova Discovery Performance Unit, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K.<br /><searchLink fieldCode="AU" term="%22Gordon+L%22">Gordon L</searchLink>; Platform Technology and Sciences, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K.<br /><searchLink fieldCode="AU" term="%22Haslam+C%22">Haslam C</searchLink>; Platform Technology and Sciences, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K.<br /><searchLink fieldCode="AU" term="%22Hayhow+TG%22">Hayhow TG</searchLink>; Epinova Discovery Performance Unit, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K.<br /><searchLink fieldCode="AU" term="%22Humphreys+PG%22">Humphreys PG</searchLink>; Epinova Discovery Performance Unit, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K.<br /><searchLink fieldCode="AU" term="%22Joberty+G%22">Joberty G</searchLink>; Cellzome GmbH, a GSK Company , Meyerhofstrasse 1, 69117 Heidelberg, Germany.<br /><searchLink fieldCode="AU" term="%22Katso+R%22">Katso R</searchLink>; Platform Technology and Sciences, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K.<br /><searchLink fieldCode="AU" term="%22Kruidenier+L%22">Kruidenier L</searchLink>; Epinova Discovery Performance Unit, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K.<br /><searchLink fieldCode="AU" term="%22Leveridge+M%22">Leveridge M</searchLink>; Platform Technology and Sciences, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K.<br /><searchLink fieldCode="AU" term="%22Pemberton+M%22">Pemberton M</searchLink>; Platform Technology and Sciences, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K.<br /><searchLink fieldCode="AU" term="%22Rioja+I%22">Rioja I</searchLink>; Epinova Discovery Performance Unit, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K.<br /><searchLink fieldCode="AU" term="%22Seal+GA%22">Seal GA</searchLink>; Epinova Discovery Performance Unit, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K.<br /><searchLink fieldCode="AU" term="%22Shipley+T%22">Shipley T</searchLink>; Epinova Discovery Performance Unit, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K.<br /><searchLink fieldCode="AU" term="%22Singh+O%22">Singh O</searchLink>; Platform Technology and Sciences, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K.<br /><searchLink fieldCode="AU" term="%22Suckling+CJ%22">Suckling CJ</searchLink>; Department of Pure and Applied Chemistry, WestCHEM Research School, University of Strathclyde , Glasgow G1 1XL, U.K.<br /><searchLink fieldCode="AU" term="%22Taylor+J%22">Taylor J</searchLink>; Platform Technology and Sciences, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K.<br /><searchLink fieldCode="AU" term="%22Thomas+P%22">Thomas P</searchLink>; Platform Technology and Sciences, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K.<br /><searchLink fieldCode="AU" term="%22Wilson+DM%22">Wilson DM</searchLink>; Epinova Discovery Performance Unit, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K.<br /><searchLink fieldCode="AU" term="%22Lee+K%22">Lee K</searchLink>; Epinova Discovery Performance Unit, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K.<br /><searchLink fieldCode="AU" term="%22Prinjha+RK%22">Prinjha RK</searchLink>; Epinova Discovery Performance Unit, Medicines Research Centre, GlaxoSmithKline R&D , Stevenage SG1 2NY, U.K.
– Name: TitleSource
  Label: Source
  Group: Src
  Data: <searchLink fieldCode="JN" term="%229716531%22">Journal of medicinal chemistry</searchLink> [J Med Chem] 2016 Feb 25; Vol. 59 (4), pp. 1370-87. <i>Date of Electronic Publication: </i>2016 Jan 15.
– Name: TypePub
  Label: Publication Type
  Group: TypPub
  Data: Journal Article
– Name: TitleSource
  Label: Journal Info
  Group: Src
  Data: <i>Publisher: </i><searchLink fieldCode="PB" term="%22American+Chemical+Society%22">American Chemical Society </searchLink><i>Country of Publication: </i>United States <i>NLM ID: </i>9716531 <i>Publication Model: </i>Print-Electronic <i>Cited Medium: </i>Internet <i>ISSN: </i>1520-4804 (Electronic) <i>Linking ISSN: </i><searchLink fieldCode="IS" term="%2200222623%22">00222623 </searchLink><i>NLM ISO Abbreviation: </i>J Med Chem <i>Subsets: </i>MEDLINE
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&db=mdl&AN=26771203
RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1021/acs.jmedchem.5b01538
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        StartPage: 1370
    Titles:
      – TitleFull: Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives.
        Type: main
  BibRelationships:
    HasContributorRelationships:
      – PersonEntity:
          Name:
            NameFull: Westaway SM
      – PersonEntity:
          Name:
            NameFull: Preston AG
      – PersonEntity:
          Name:
            NameFull: Barker MD
      – PersonEntity:
          Name:
            NameFull: Brown F
      – PersonEntity:
          Name:
            NameFull: Brown JA
      – PersonEntity:
          Name:
            NameFull: Campbell M
      – PersonEntity:
          Name:
            NameFull: Chung CW
      – PersonEntity:
          Name:
            NameFull: Drewes G
      – PersonEntity:
          Name:
            NameFull: Eagle R
      – PersonEntity:
          Name:
            NameFull: Garton N
      – PersonEntity:
          Name:
            NameFull: Gordon L
      – PersonEntity:
          Name:
            NameFull: Haslam C
      – PersonEntity:
          Name:
            NameFull: Hayhow TG
      – PersonEntity:
          Name:
            NameFull: Humphreys PG
      – PersonEntity:
          Name:
            NameFull: Joberty G
      – PersonEntity:
          Name:
            NameFull: Katso R
      – PersonEntity:
          Name:
            NameFull: Kruidenier L
      – PersonEntity:
          Name:
            NameFull: Leveridge M
      – PersonEntity:
          Name:
            NameFull: Pemberton M
      – PersonEntity:
          Name:
            NameFull: Rioja I
      – PersonEntity:
          Name:
            NameFull: Seal GA
      – PersonEntity:
          Name:
            NameFull: Shipley T
      – PersonEntity:
          Name:
            NameFull: Singh O
      – PersonEntity:
          Name:
            NameFull: Suckling CJ
      – PersonEntity:
          Name:
            NameFull: Taylor J
      – PersonEntity:
          Name:
            NameFull: Thomas P
      – PersonEntity:
          Name:
            NameFull: Wilson DM
      – PersonEntity:
          Name:
            NameFull: Lee K
      – PersonEntity:
          Name:
            NameFull: Prinjha RK
    IsPartOfRelationships:
      – BibEntity:
          Dates:
            – D: 25
              M: 02
              Text: 2016 Feb 25
              Type: published
              Y: 2016
          Identifiers:
            – Type: issn-electronic
              Value: 1520-4804
          Numbering:
            – Type: volume
              Value: 59
            – Type: issue
              Value: 4
          Titles:
            – TitleFull: Journal of medicinal chemistry
              Type: main
ResultId 1