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Population pharmacokinetic/pharmacodynamic modelling of the effects of axomadol and its O-demethyl metabolite on pupil diameter and nociception in healthy subjects.

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Title: Population pharmacokinetic/pharmacodynamic modelling of the effects of axomadol and its O-demethyl metabolite on pupil diameter and nociception in healthy subjects.
Authors: Mangas-Sanjuan V; Pharmacometrics and Systems Pharmacology, Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, Spain.; Area of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University Miguel Hernández, Alicante, Spain., Pastor JM; Pharmacometrics and Systems Pharmacology, Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, Spain., Rengelshausen J; Early Clinical Science, Grünenthal GmbH, Aachen, Germany., Bursi R; Pharmacometrics, Grünenthal GmbH, Aachen, Germany., Troconiz IF; Pharmacometrics and Systems Pharmacology, Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, Spain.; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain.
Source: British journal of clinical pharmacology [Br J Clin Pharmacol] 2016 Jul; Vol. 82 (1), pp. 92-107. Date of Electronic Publication: 2016 Apr 14.
Publication Type: Clinical Trial, Phase I; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
Journal Info: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 7503323 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1365-2125 (Electronic) Linking ISSN: 03065251 NLM ISO Abbreviation: Br J Clin Pharmacol Subsets: MEDLINE
Database: MEDLINE Ultimate
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  Data: Population pharmacokinetic/pharmacodynamic modelling of the effects of axomadol and its O-demethyl metabolite on pupil diameter and nociception in healthy subjects.
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  Data: <searchLink fieldCode="AU" term="%22Mangas-Sanjuan+V%22">Mangas-Sanjuan V</searchLink>; Pharmacometrics and Systems Pharmacology, Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, Spain.; Area of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University Miguel Hernández, Alicante, Spain.<br /><searchLink fieldCode="AU" term="%22Pastor+JM%22">Pastor JM</searchLink>; Pharmacometrics and Systems Pharmacology, Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, Spain.<br /><searchLink fieldCode="AU" term="%22Rengelshausen+J%22">Rengelshausen J</searchLink>; Early Clinical Science, Grünenthal GmbH, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Bursi+R%22">Bursi R</searchLink>; Pharmacometrics, Grünenthal GmbH, Aachen, Germany.<br /><searchLink fieldCode="AU" term="%22Troconiz+IF%22">Troconiz IF</searchLink>; Pharmacometrics and Systems Pharmacology, Department of Pharmacy and Pharmaceutical Technology, School of Pharmacy, University of Navarra, Pamplona, Spain.; IdiSNA, Navarra Institute for Health Research, Pamplona, Spain.
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  Data: <searchLink fieldCode="JN" term="%227503323%22">British journal of clinical pharmacology</searchLink> [Br J Clin Pharmacol] 2016 Jul; Vol. 82 (1), pp. 92-107. <i>Date of Electronic Publication: </i>2016 Apr 14.
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        Value: 10.1111/bcp.12921
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              Text: 2016 Jul
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